CTCF-RNA interactions orchestrate cell-specific chromatin loop organization.

Lucero K, Han S, Huang PY, Qiu X, Mazzoni EO, Reinberg D.
bioRxiv [Preprint].

Update in pubmed.ncbi.nlm.nih.gov/41296854/

Sci Adv. 2025 Nov 28; DOI: 10.1126/sciadv.ady5507

CTCF binding landscape is shaped by the epigenetic state of the N-terminal nucleosome in relation to CTCF motif orientation

M. Tajmul, D. N. Bhatt, L. Ruje, E. Price, Y. Ji, D. Loukinov, V. B. Teif, V. V. Lobanenkov, E. M. Pugacheva

revised May 23, 2025
biorxiv.org/content/10.1...

BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6806-11. www.pnas.org/doi/full/10....

CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease

Review - Trends Genet. 2001 Sep;17(9):520-7. www.sciencedirect.com/science/arti...

Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions

genomebiology.biomedcentral.com/articles/10....

🥸 Here you can find many verifiable facts and personal commentaries related to the discovery of paralogous CTCF and CTCF Like BORIS transcriptional factors which share near identical eleven multivalent DNA-binding zinc fingers...

...and which used to be @ x.com/boris_ctcf