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crukcamctya.bsky.social
CRUK Cambridge Centre: CTYA Cancers
@crukcamctya.bsky.social
Posting about CTYA cancers research, education and events from the Childhood, Teenage and Young Adult Cancers Programme at the
@crukcamcentre.bsky.social. Find out more at: www.crukcc.org/ctya
Reposted by CRUK Cambridge Centre: CTYA Cancers
🎗This September @crukcamctya.bsky.social have shared research & patient stories shaping the future of childhood, teenage & young adult cancer care in Cambridge. Want to see more?

Explore highlights 👉 zurl.co/k9IGU
#ChildhoodCancerAwarenessMonth #CCAM25
September 30, 2025 at 9:00 AM
🎗️ Thank you for supporting #ChildhoodCancerAwarenessMonth and following our @crukcamcentre.bsky.social updates from the last year! You can find everything we have shared on our website > buff.ly/hxvGWCu
September 30, 2025 at 7:30 AM
As part of our PPI activities, the @crukcamcentre.bsky.social supported the annual Paediatric Oncology Activity Day organised by the paediatric haematology and oncology team at Addenbrooke’s Hospital @cuh.nhs.uk . buff.ly/8bsvYLK
September 29, 2025 at 7:30 AM
An example of PPI in CTYA cancer: spotlighting the power of collaboration. In Cambridge, mums, researchers, and a young adult patient met in person for the first time to talk about a rare cancer - Anaplastic Large Cell Lymphoma (ALCL). buff.ly/W1frJTx
A global meeting of minds | CRUK CC
On Friday 27 June 2025, mothers, researchers, and a young adult patient came together for the first time in person in Cambridge.These mums and patient, who have formed a supportive online network…
crukcambridgecentre.org.uk
September 26, 2025 at 12:31 PM
Reposted by CRUK Cambridge Centre: CTYA Cancers
📢 Today is the first ever #CancerCachexiaAwarenessDay!

Cachexia is a wasting syndrome that causes people with cancer to lose weight & muscle even when eating normally. Find out more on the @cancerresearchuk.org ➡️ zurl.co/kxTa3
September 26, 2025 at 8:59 AM
Research is not just about labs and data—it’s about people. Patients and the public play a crucial role in shaping the future of cancer treatment. At @crukcamcentre.bsky.social, we put a priority on partnering with those affected by cancer to ensure research is aligned with real-world needs.
September 26, 2025 at 7:30 AM
Reposted by CRUK Cambridge Centre: CTYA Cancers
In Cambridge, patients & families are co-driving childhood cancer research – shaping priorities & ensuring it meets real-world needs. 🙌

Join our PPI network 👉 zurl.co/A4msb or email ctya.ppie@cancer.cam.ac.uk
#ChildhoodCancerAwarenessMonth #CCAM25 @crukcamctya.bsky.social
September 25, 2025 at 9:00 AM
A recent study sheds light on the long-term effects of chemotherapy on healthy blood cells, revealing that treatment can induce mutations and accelerate aging in blood cell populations. These findings are crucial for improving treatments for children with cancer. buff.ly/FsuUp0V
The long-term effects of chemotherapy on normal blood cells - Nature Genetics
Mutational signature analysis of blood cells isolated from 23 chemotherapy-exposed samples and 9 nonexposed controls characterizes the effects of various drugs on mutational burden, signature…
doi.org
September 24, 2025 at 7:30 AM
Cambridge scientists funded by @cancerresearchuk.org and based at @crukcamcentre.bsky.social have discovered a promising new treatment approach for B-cell acute lymphoblastic leukaemia (B-ALL)—the most common cancer in children. buff.ly/UUWScph
Potential new treatment to tackle commonest form of childhood cancer
A combination of two drugs could improve outcomes and reduce the need for toxic chemotherapy for B-cell acute lymphoblastic leukaemia, the commonest cancer in childhood and one that can be…
www.cam.ac.uk
September 23, 2025 at 7:30 AM
Reposted by CRUK Cambridge Centre: CTYA Cancers
💛 This summer we had fun supporting the @cuh.nhs.uk Paediatric Oncology Activity Day at @jesuscollegecam.bsky.social – uniting young patients, families, researchers & healthcare teams for 30+ fun activities from tennis to pipetting! #ChildhoodCancerAwarenessMonth #CCAM25 @crukcamctya.bsky.social
September 19, 2025 at 10:06 AM
Reposted by CRUK Cambridge Centre: CTYA Cancers
🧬 Whole genome sequencing is reshaping childhood cancer care. At Cambridge, it’s helping diagnose rare cancers, guide treatment & support families.

🔗 Find out more zurl.co/mYdg3
#ChildhoodCancerAwarenessMonth #CCAM25 @crukcamctya.bsky.social
September 22, 2025 at 9:00 AM
Whole genome sequencing (WGS) is becoming increasingly vital in paediatric oncology. However, its full potential is hindered by barriers such as lack of awareness and integration into clinical workflows. buff.ly/rI4LkIk
September 22, 2025 at 7:30 AM
Neuroblastoma is a childhood cancer of nerve cells, often driven by faults in a gene called ALK. Drugs called ALK inhibitors, like lorlatinib, can help—but some tumours manage to resist these treatments. buff.ly/81QjAsg
FGFR2 promotes resistance to ALK tyrosine kinase inhibitors and its inhibition acts synergistically with lorlatinib in the treatment of ALK-expressing neuroblastoma
Anaplastic Lymphoma Kinase inhibitors (ALK TKIs) are approved for the treatment of ALK-positive non-small cell lung cancer (NSCLC) and are in clinical trial for ALK-aberrant high-risk neuroblastoma…
www.biorxiv.org
September 19, 2025 at 7:30 AM
Neuroblastoma is a rare childhood cancer that happens when immature nerve cells (called neuroblasts) grow uncontrollably. It mainly affects babies and young children, usually starting in the tummy area or adrenal glands. buff.ly/DvoJ9BB
September 18, 2025 at 7:30 AM
Cambridge research funded by @cancerresearchuk.org brings new insights into Neurofibromatosis Type 1 (NF1) and Childhood Cancer. buff.ly/6355Xfl
Cancer-independent somatic mutation of the wild-type NF1 allele in normal tissues in neurofibromatosis type 1 - PubMed
Cancer predisposition syndromes mediated by recessive cancer genes generate tumors via somatic variants (second hits) in the unaffected allele. Second hits may or may not be sufficient for neoplastic…
pubmed.ncbi.nlm.nih.gov
September 17, 2025 at 7:30 AM
This Childhood Cancer Awareness Month, we highlight a pivotal study that delves into the genetic underpinnings of testicular germ cell tumours (TGCTs), the most common cancer in young men. crukcambridgecentre.org.uk/news/dna-dup...
DNA duplication revealed as key cause of testicular cancer | CRUK CC
Malignant germ cell tumours (GCTs) are complex cancers that affect patients of all ages. They develop from cells that produce eggs or sperm and mostly occur in the ovaries and testes.Around 2,500 men…
crukcambridgecentre.org.uk
September 16, 2025 at 7:30 AM
Reposted by CRUK Cambridge Centre: CTYA Cancers
This #ChildhoodCancerAwarenessMonth meet the Young NHL Network, a group connecting early career researchers in paediatric non-Hodgkin lymphoma to promote collaboration and innovation. Join the network on LinkedIn ➡️ zurl.co/zo70u @crukcamctya.bsky.social

youtu.be/SmgPETR-vC0
Introduction to the Young NHL Network
YouTube video by Cancer Research UK Cambridge Centre
youtu.be
September 15, 2025 at 10:11 AM
This Childhood Cancer Awareness Month, we highlight groundbreaking research focused on developing gentler treatments for children with germ cell tumours, aiming to improve survival rates while reducing long-term side effects. crukcambridgecentre.org.uk/news/develop...
Developing kinder treatments for patients with germ cell tumours | CRUK CC
In this work, published in the Molecular Oncology journal, the team identified a set of microRNAs found at low levels in malignant GCTs. When these microRNAs were reintroduced into tumour cells, and…
crukcambridgecentre.org.uk
September 15, 2025 at 7:30 AM
A recent study delves into how the protein ASCL1 influences cell reprogramming, a process crucial for developing new therapies for childhood cancers. buff.ly/A8evTnS
Phospho-regulation of ASCL1-mediated chromatin opening during cellular reprogramming
Highlighted Article: The enhanced activity of phosphomutant ASCL1 depends on more efficient chromatin remodelling during in vitro neurogenesis.
doi.org
September 12, 2025 at 7:30 AM
This Childhood Cancer Awareness Month, we highlight two important studies from the Murray lab on bifocal germinomas—rare and complex brain tumours. These studies are advancing our understanding of diagnosis and treatment, offering hope for improved care.
September 11, 2025 at 7:30 AM
A recent publication from researchers across programmes at the Cancer Research UK Cambridge Centre explores gene context drift in cancer therapy resistance in the first ever clinical trial of a targeted therapy in choroid plexus carcinoma. buff.ly/cY7zTOI
Gene context drift identifies drug targets to mitigate cancer treatment resistance
Jassim et al. introduce a graph-embedding computational pipeline (RECODR) that measures changes in gene co-expression context during cancer treatment. RECODR enables the design of highly effective…
www.cell.com
September 10, 2025 at 7:30 AM
Reposted by CRUK Cambridge Centre: CTYA Cancers
September is #ChildhoodCancerAwarenessMonth and @crukcamctya.bsky.social have been sharing some of their research and updates from the past year on their social media channels.

Follow @crukcamctya.bsky.social for daily updates!
Find a summary on our website ➡️  zurl.co/n8aGX
 
#CCAM25 #CCAM2025
September 9, 2025 at 9:00 AM
This #childhoodcancerawarenessmonth, we highlight Dr. Jessica Taylor's pioneering work at the @cruk-ci.bsky.social. Her research focuses on improving outcomes for children with brain tumours, aiming not just for survival but for quality of life. buff.ly/tN83I1z
Spotlight on Dr Jessica Taylor | CRUK CC
She is the Training Lead for the Brain Cancer Virtual at the Cancer Research UK Cambridge Centre and a member of the Cancer Research UK Children's Brain Tumour Centre of Excellence. As an…
crukcambridgecentre.org.uk
September 9, 2025 at 7:30 AM
Brain tumours are among the toughest challenges in childhood cancer. The Cancer Research UK Children’s Brain Tumour Centre of Excellence —led by @crukcamcentre.bsky.social and partners—brings together world-leading experts. buff.ly/5LnvfDh
CRUK Children's Brain Tumour Centre of Excellence
Hosted by The University of Cambridge and The Institute of Cancer Research, London
www.crukchildrensbraintumourcentre.org
September 8, 2025 at 7:30 AM