@crismayorruiz.bsky.social
Passionate scientist, runner, basket. Group leader at #IRBBarcelona | Targeted protein degradation | Chemical biology
Congrats Will & team!!
March 11, 2025 at 9:04 AM
Congrats Will & team!!
Reposted
📌 La Dra. Ana Domostegui desarrolla un nuevo tipo de fármacos innovadores, denominados fármacos degradadores de proteínas, para el tratamiento del #CáncerdePáncreas.
February 24, 2025 at 12:25 PM
📌 La Dra. Ana Domostegui desarrolla un nuevo tipo de fármacos innovadores, denominados fármacos degradadores de proteínas, para el tratamiento del #CáncerdePáncreas.
Reposted
📌 PROTECT:
En el marco de @cancergrand.bsky.social, el proyecto liderado por la Dra. @crismayorruiz.bsky.social desarrollará fármacos degradadores de proteínas para luchar contra los tumores pediátricos.
En el marco de @cancergrand.bsky.social, el proyecto liderado por la Dra. @crismayorruiz.bsky.social desarrollará fármacos degradadores de proteínas para luchar contra los tumores pediátricos.
February 24, 2025 at 12:25 PM
📌 PROTECT:
En el marco de @cancergrand.bsky.social, el proyecto liderado por la Dra. @crismayorruiz.bsky.social desarrollará fármacos degradadores de proteínas para luchar contra los tumores pediátricos.
En el marco de @cancergrand.bsky.social, el proyecto liderado por la Dra. @crismayorruiz.bsky.social desarrollará fármacos degradadores de proteínas para luchar contra los tumores pediátricos.
The office had never been so busy!!😅
December 24, 2024 at 6:14 PM
The office had never been so busy!!😅
Huge congrats to #Alberto & #Inés, co-first authors! Amazing team effort with many other friends: Toni, Pep, Carlos, Caro, etc. @irbbarcelona.bsky.social
December 16, 2024 at 4:54 PM
Huge congrats to #Alberto & #Inés, co-first authors! Amazing team effort with many other friends: Toni, Pep, Carlos, Caro, etc. @irbbarcelona.bsky.social
Specifically, this allowed us to:
(i) Study the therapeutic efficacy of KRAS(G12V)-targeted degradation in vivo
(ii) Dissect tumor regression mechanisms (cell-intrinsic/extrinsic)
(iii) Investigate resistance
Curious to learn more? Take a look! www.biorxiv.org/content/10.1...
(i) Study the therapeutic efficacy of KRAS(G12V)-targeted degradation in vivo
(ii) Dissect tumor regression mechanisms (cell-intrinsic/extrinsic)
(iii) Investigate resistance
Curious to learn more? Take a look! www.biorxiv.org/content/10.1...
Targeted KRAS(G12V) degradation elicits efficient and durable lung adenocarcinoma regression in vivo
Recent drug discovery breakthroughs led to the approval of KRASG12C inhibitors in lung adenocarcinoma (LUAD). Unfortunately, clinical responses remain limited due to rapid resistance onset. Proteolysi...
www.biorxiv.org
December 16, 2024 at 4:54 PM
Specifically, this allowed us to:
(i) Study the therapeutic efficacy of KRAS(G12V)-targeted degradation in vivo
(ii) Dissect tumor regression mechanisms (cell-intrinsic/extrinsic)
(iii) Investigate resistance
Curious to learn more? Take a look! www.biorxiv.org/content/10.1...
(i) Study the therapeutic efficacy of KRAS(G12V)-targeted degradation in vivo
(ii) Dissect tumor regression mechanisms (cell-intrinsic/extrinsic)
(iii) Investigate resistance
Curious to learn more? Take a look! www.biorxiv.org/content/10.1...
Chemical, tumor-specific modulation of KRAS(G12V) protein abundance served here to probe the therapeutic potential of oncoprotein degradation and to selectively dissect the biological outcomes!
December 16, 2024 at 4:54 PM
Chemical, tumor-specific modulation of KRAS(G12V) protein abundance served here to probe the therapeutic potential of oncoprotein degradation and to selectively dissect the biological outcomes!
We developed a preclinical mouse model of lung adenocarcinoma in which we can induce selective KRAS(G12V) degradation in vivo, leveraging the dTAG system
December 16, 2024 at 4:54 PM
We developed a preclinical mouse model of lung adenocarcinoma in which we can induce selective KRAS(G12V) degradation in vivo, leveraging the dTAG system
Reposted
Women in chemistry starter pack here: go.bsky.app/LjumNEg
#ChemSky
please repost :D
#ChemSky #realtimechem #FluorescenceFriday
#ChemSky
please repost :D
#ChemSky #realtimechem #FluorescenceFriday
November 17, 2024 at 11:42 PM
Women in chemistry starter pack here: go.bsky.app/LjumNEg
#ChemSky
please repost :D
#ChemSky #realtimechem #FluorescenceFriday
#ChemSky
please repost :D
#ChemSky #realtimechem #FluorescenceFriday