Charlie Wilson
@crewilson.bsky.social
🧠 Neuroscientist at INSERM SBRI Lyon 🧠
Prefrontal neural dynamics, learning to learn, oscillations, occasional 🐒 chat.
🇬🇧 in 🇫🇷; Conductor; horn player; slow cyclist.
Prefrontal neural dynamics, learning to learn, oscillations, occasional 🐒 chat.
🇬🇧 in 🇫🇷; Conductor; horn player; slow cyclist.
Yes, sorry, got distracted earlier (literally by some French people going on strike 🇫🇷) but meant to follow-up with Baxter's paper. We have datasets on their slow way out which support their finding of no behavioural (or for us ephys) evidence of off-target effects at 0.1mg/kg DCZ sans DREADDs.
January 14, 2025 at 9:59 PM
Yes, sorry, got distracted earlier (literally by some French people going on strike 🇫🇷) but meant to follow-up with Baxter's paper. We have datasets on their slow way out which support their finding of no behavioural (or for us ephys) evidence of off-target effects at 0.1mg/kg DCZ sans DREADDs.
We do control DCZ injections prior to vector surgery for this reason. "Off target" effects at higher doses have been shown (paper from @rudebecklab.bsky.social and @russbeneuro.bsky.social www.jneurosci.org/content/42/2...), and we have seen similar things in MRI but so far not in ephys/behaviour.
Resting-State fMRI-Based Screening of Deschloroclozapine in Rhesus Macaques Predicts Dosage-Dependent Behavioral Effects
Chemogenetic techniques, such as designer receptors exclusively activated by designer drugs (DREADDs), enable transient, reversible, and minimally invasive manipulation of neural activity in vivo . Th...
www.jneurosci.org
January 14, 2025 at 3:13 PM
We do control DCZ injections prior to vector surgery for this reason. "Off target" effects at higher doses have been shown (paper from @rudebecklab.bsky.social and @russbeneuro.bsky.social www.jneurosci.org/content/42/2...), and we have seen similar things in MRI but so far not in ephys/behaviour.
Mr White *deserves* to taste that prime rib...
December 26, 2024 at 10:13 PM
Mr White *deserves* to taste that prime rib...
It is, needless to say, magnificent.
December 26, 2024 at 9:55 PM
It is, needless to say, magnificent.
Year of my birth, a very treasured present. I've planned it for the last glass on my 50th...
December 26, 2024 at 9:55 PM
Year of my birth, a very treasured present. I've planned it for the last glass on my 50th...
I still have a bottle of 1979 on the go... slow...
December 26, 2024 at 9:49 PM
I still have a bottle of 1979 on the go... slow...
Bravo Jimmy.
But perfect might be stretching it a bit....
But perfect might be stretching it a bit....
December 18, 2024 at 1:21 PM
Bravo Jimmy.
But perfect might be stretching it a bit....
But perfect might be stretching it a bit....
Congratulations to Sotirios and all!
But also if you're already skeeting paper threads, you didn't party hard enough last night...
But also if you're already skeeting paper threads, you didn't party hard enough last night...
December 18, 2024 at 1:18 PM
Congratulations to Sotirios and all!
But also if you're already skeeting paper threads, you didn't party hard enough last night...
But also if you're already skeeting paper threads, you didn't party hard enough last night...
Would appreciate being part of this if it is possible. Plenty of frontal beta work coming up… Thanks
November 26, 2024 at 11:33 PM
Would appreciate being part of this if it is possible. Plenty of frontal beta work coming up… Thanks