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direct medrxiv link is here. www.medrxiv.org/content/10.1...
Divergent antibody-mediated population immunity to H5, H7 and H9 subtype potential pandemic influenza viruses
Influenza continues to cause significant mortality globally and possesses substantial pandemic potential. Assessing pandemic risk requires a clear understanding of existing population immunity. Levera...
www.medrxiv.org
September 10, 2025 at 12:33 PM
direct medrxiv link is here. www.medrxiv.org/content/10.1...
- Both H5 and H7 subtype influenza viruses show some degree of neutralisation through receptor binding site-adjacent epitopes.
September 10, 2025 at 9:58 AM
- Both H5 and H7 subtype influenza viruses show some degree of neutralisation through receptor binding site-adjacent epitopes.
- H7 subtype viruses are primarily neutralised by antibodies targeting the HA head domain, whilst H5 subtype viruses are mainly neutralised by antibodies
targeting the HA stem region.
targeting the HA stem region.
September 10, 2025 at 9:58 AM
- H7 subtype viruses are primarily neutralised by antibodies targeting the HA head domain, whilst H5 subtype viruses are mainly neutralised by antibodies
targeting the HA stem region.
targeting the HA stem region.
- H7 HA total antibody responses are dominated by non-glycan-targeted IgG2 antibodies while H5 HA total antibody responses are primarily IgG1 dominated.
September 10, 2025 at 9:58 AM
- H7 HA total antibody responses are dominated by non-glycan-targeted IgG2 antibodies while H5 HA total antibody responses are primarily IgG1 dominated.
Key findings:
- Population immunity to potential pandemic H5, H7, H9 subtype influenza viruses varies significantly across different age groups. These trends align with historical circulation patterns of seasonal H1N1 and H3N2 viruses in humans.
- Population immunity to potential pandemic H5, H7, H9 subtype influenza viruses varies significantly across different age groups. These trends align with historical circulation patterns of seasonal H1N1 and H3N2 viruses in humans.
September 10, 2025 at 9:57 AM
Key findings:
- Population immunity to potential pandemic H5, H7, H9 subtype influenza viruses varies significantly across different age groups. These trends align with historical circulation patterns of seasonal H1N1 and H3N2 viruses in humans.
- Population immunity to potential pandemic H5, H7, H9 subtype influenza viruses varies significantly across different age groups. These trends align with historical circulation patterns of seasonal H1N1 and H3N2 viruses in humans.