Craig Gedye
@craiggedye.bsky.social
Medical oncologist, physician/scientist
#cansky #oncosky #clinicaltrials #kidneycancer #braincancer #prostatecancer #btsm #pcsm #kcsm @anzuptrials.bsky.social @COGNOtrials @iconcancercentre.bsky.social
Posts my opinion only. #FCOI http://bit.ly/3xKTdPm
#cansky #oncosky #clinicaltrials #kidneycancer #braincancer #prostatecancer #btsm #pcsm #kcsm @anzuptrials.bsky.social @COGNOtrials @iconcancercentre.bsky.social
Posts my opinion only. #FCOI http://bit.ly/3xKTdPm
When life gives you sour mandarins...
October 19, 2025 at 9:56 PM
When life gives you sour mandarins...
And the infographic Research Summary as well www.nejm.org/do/10.1056/N.... Clinical trials only become healthcare if you communicate the result. Ringer's no better than saline BTW.
August 16, 2025 at 11:03 PM
And the infographic Research Summary as well www.nejm.org/do/10.1056/N.... Clinical trials only become healthcare if you communicate the result. Ringer's no better than saline BTW.
#Teletrials in action: a generous and kind participant called me this week for Visit #3 of his participation in @anzuptrials.bsky.social #ANZadapt #clinicaltrial. “Where are you?”, I asked. “Let me send you a photo”, he said. How’s the serenity…
May 9, 2025 at 9:52 PM
#Teletrials in action: a generous and kind participant called me this week for Visit #3 of his participation in @anzuptrials.bsky.social #ANZadapt #clinicaltrial. “Where are you?”, I asked. “Let me send you a photo”, he said. How’s the serenity…
And what about those Phillip Island little penguins... they used to be called FAIRY penguins... enough said... +10%. www.penguins.org.au
April 4, 2025 at 10:58 PM
And what about those Phillip Island little penguins... they used to be called FAIRY penguins... enough said... +10%. www.penguins.org.au
It gets better; vaccination is preventing cancers! Take the incredible example of HPV vaccination for cervical cancer prevention; if we can offer protection to everyone around the world, we could prevent suffering and death for millions of people. And reduce oral and other cancers too!
March 30, 2025 at 1:35 AM
It gets better; vaccination is preventing cancers! Take the incredible example of HPV vaccination for cervical cancer prevention; if we can offer protection to everyone around the world, we could prevent suffering and death for millions of people. And reduce oral and other cancers too!
An opportunity to engage. This is 'half of the truth'. Cancers have gone up since vaccination... because we are living longer on average! Long enough to be at risk for cancer, because children don't die of measles, diptheria, polio etc. Compare incidence in high vs LMIC. ourworldindata.org/cancer
March 30, 2025 at 12:36 AM
An opportunity to engage. This is 'half of the truth'. Cancers have gone up since vaccination... because we are living longer on average! Long enough to be at risk for cancer, because children don't die of measles, diptheria, polio etc. Compare incidence in high vs LMIC. ourworldindata.org/cancer
Great piece from Lancet Global Health on democratising clinical trials research to strengthen primary healthcare, relevant to ALL healthcare. Every healthcare intervention is a clinical trial of n = 1; why not learn from every patient, every clinician?
March 27, 2025 at 8:44 PM
Great piece from Lancet Global Health on democratising clinical trials research to strengthen primary healthcare, relevant to ALL healthcare. Every healthcare intervention is a clinical trial of n = 1; why not learn from every patient, every clinician?
That might have been written for me. Clinicians sometimes need reinforcement of the bleeding obvious. Like when radiologists put a green arrow on the x-ray report, to say 'ummm, this life-threatening things here'.
March 1, 2025 at 9:20 PM
That might have been written for me. Clinicians sometimes need reinforcement of the bleeding obvious. Like when radiologists put a green arrow on the x-ray report, to say 'ummm, this life-threatening things here'.
Send in the clones. Two papers in this week's @nature.com compare/contrast personalized neoantigen mRNA vaccines, with extraordinary success as adjuvant therapy in pancreatic cancer, but not helping when given late in lung cancer. Targeting ALL clones of each person's cancer is essential.
February 23, 2025 at 8:08 AM
Send in the clones. Two papers in this week's @nature.com compare/contrast personalized neoantigen mRNA vaccines, with extraordinary success as adjuvant therapy in pancreatic cancer, but not helping when given late in lung cancer. Targeting ALL clones of each person's cancer is essential.
Take your chemo at night? Retrospective analysis of two large clinical trials suggests when you take temozolomide (am, pm, night) makes no difference in survival in #glioblastoma. Side effects might be better if taken at night. academic.oup.com/nop/advance-... @eortc.bsky.social
February 22, 2025 at 2:45 AM
Take your chemo at night? Retrospective analysis of two large clinical trials suggests when you take temozolomide (am, pm, night) makes no difference in survival in #glioblastoma. Side effects might be better if taken at night. academic.oup.com/nop/advance-... @eortc.bsky.social
Finally meeting @asharpmedonc.bsky.social in person #GU25
February 14, 2025 at 10:21 PM
Finally meeting @asharpmedonc.bsky.social in person #GU25
Overall survival improved adding LuPSMA to enza in people with high risk prostate cancer, with almost 40% taking LuPSMA post study @anzuptrials.bsky.social @ascocancer.bsky.social #GU25
February 13, 2025 at 7:03 PM
Overall survival improved adding LuPSMA to enza in people with high risk prostate cancer, with almost 40% taking LuPSMA post study @anzuptrials.bsky.social @ascocancer.bsky.social #GU25
Excited for Prof Louise Emmett presenting #ENZAp today at #GU25 on behalf of @anzuptrials.bsky.social @ascocancer.bsky.social
February 13, 2025 at 6:15 PM
Excited for Prof Louise Emmett presenting #ENZAp today at #GU25 on behalf of @anzuptrials.bsky.social @ascocancer.bsky.social
Further data helping us personalise advanced prostate cancer treatment from a meta-analysis from @mrcnihrtmrp.bsky.social @ascocancer.bsky.social #GU25
February 13, 2025 at 5:30 PM
Further data helping us personalise advanced prostate cancer treatment from a meta-analysis from @mrcnihrtmrp.bsky.social @ascocancer.bsky.social #GU25
europepmc.org but do we need a federated international data system to ensure long-term sustainability?
January 28, 2025 at 8:56 PM
europepmc.org but do we need a federated international data system to ensure long-term sustainability?
The change in the blood test may predict the outcome of treatment. As an example, one person saw their cancer grow and decided to start treatment, and their ctDNA blood test reflected a good response to this treatment.
December 26, 2024 at 11:34 PM
The change in the blood test may predict the outcome of treatment. As an example, one person saw their cancer grow and decided to start treatment, and their ctDNA blood test reflected a good response to this treatment.
Even more interestingly, for people starting with wait-and-watch, the same applies - if the cancer's ctDNA was undetectable or disappeared, their cancers also stayed stable on scans. Some people did choose/need to start treatment, and most often their ctDNA had increased/become detectable.
December 26, 2024 at 11:34 PM
Even more interestingly, for people starting with wait-and-watch, the same applies - if the cancer's ctDNA was undetectable or disappeared, their cancers also stayed stable on scans. Some people did choose/need to start treatment, and most often their ctDNA had increased/become detectable.
For people taking treatment already, if the cancer's DNA was not able to be detected, or disappeared, the size of the cancer on x-rays and scans was likely to stay stable
December 26, 2024 at 11:34 PM
For people taking treatment already, if the cancer's DNA was not able to be detected, or disappeared, the size of the cancer on x-rays and scans was likely to stay stable
Following each person's cancer via their blood test gave insights on their cancer and how the treatment was working. The graph on the left is people taking treatment, on the right are people on wait-and-watch.
December 26, 2024 at 11:34 PM
Following each person's cancer via their blood test gave insights on their cancer and how the treatment was working. The graph on the left is people taking treatment, on the right are people on wait-and-watch.
This was a real-world study, from many hospitals, of 92 people using a variety of tests for ctDNA, with about 500 individual blood tests in all. Two-thirds were taking drug treatments like immunotherapy or targeted therapy; one-third were taking a watch-and-wait approach called active surveillance.
December 26, 2024 at 11:34 PM
This was a real-world study, from many hospitals, of 92 people using a variety of tests for ctDNA, with about 500 individual blood tests in all. Two-thirds were taking drug treatments like immunotherapy or targeted therapy; one-third were taking a watch-and-wait approach called active surveillance.
Another step towards a blood test for #kidneycancer? When cells die some of their DNA is released into the blood. If a person has a cancer, some of the DNA comes from the cancer. If you can detect the cancer DNA, it may help find, follow and understand a person's cancer, may help guide treatment.
December 26, 2024 at 11:34 PM
Another step towards a blood test for #kidneycancer? When cells die some of their DNA is released into the blood. If a person has a cancer, some of the DNA comes from the cancer. If you can detect the cancer DNA, it may help find, follow and understand a person's cancer, may help guide treatment.
Same quality of life, same length of life, same control of cancer long-term, half the serious side-effects, one-third the time on treatment and $150 million per annum saving for the taxpayer? Sounds like a great idea for a confirmatory phase IV clinical trial in Australia!
November 30, 2024 at 12:13 AM
Same quality of life, same length of life, same control of cancer long-term, half the serious side-effects, one-third the time on treatment and $150 million per annum saving for the taxpayer? Sounds like a great idea for a confirmatory phase IV clinical trial in Australia!
What a great meeting to end the week with the @anzuptrials.bsky.social Masterclass. The ANZUP community came together to brainstorm better ways to improve the outcomes of people suffering #prostatecancer and #bladdercancer. I hope my thoughts on #clinicaltrial simplification were helpful
November 29, 2024 at 8:07 AM
What a great meeting to end the week with the @anzuptrials.bsky.social Masterclass. The ANZUP community came together to brainstorm better ways to improve the outcomes of people suffering #prostatecancer and #bladdercancer. I hope my thoughts on #clinicaltrial simplification were helpful