Craig A. Goodman
LightNews LightNews
banner
craigagoodman1.bsky.social
Craig A. Goodman
@craigagoodman1.bsky.social
500 followers 270 following 660 posts
Senior Scientist that investigates the molecular mechanisms that regulate skeletal muscle mass and function in health and in various disease states. Protein synthesis, ubiquitin biology.
https://scholar.google.com.au/citations?user=ICAcUqUAAAAJ&hl=en
Posts Replies Media Videos
craigagoodman1.bsky.social
Impaired cAMP-PKA-CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia
www.nature.com/articles/s42...
Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia - Nature Metabolism
Tumour-induced dysregulation of cAMP–PKA–CREB1 signalling in skeletal muscle is shown to be a driver of mitochondrial dysfunction, contributing to cancer cachexia in mice.
www.nature.com
November 13, 2025 at 4:29 PM
craigagoodman1.bsky.social
Fast Myosin Binding Protein-C Is a Vital Regulator in Young and Aged Fast Skeletal Muscle Homeostasis
onlinelibrary.wiley.com/doi/10.1002/...
Fast Myosin Binding Protein‐C Is a Vital Regulator in Young and Aged Fast Skeletal Muscle Homeostasis
Background Skeletal muscle plays a vital role in voluntary movement and locomotion. Fast-twitch muscle fibres are characterized by their rapid contraction kinetics, high-force generation and a disti...
onlinelibrary.wiley.com
November 13, 2025 at 4:28 PM
craigagoodman1.bsky.social
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis
www.sciencedirect.com/science/arti...
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis
Cytosolic translation activity is fine-tuned by environmental conditions primarily through signaling pathways that target translation initiation facto…
www.sciencedirect.com
November 12, 2025 at 9:04 PM
craigagoodman1.bsky.social
Lactylation of mTOR enhances autophagy in skeletal muscle during exercise
www.cell.com/cell-chemica...
Lactylation of mTOR enhances autophagy in skeletal muscle during exercise
Based on an acute exercise model, Yan et al. identify lactate as a positive regulator of autophagy in skeletal muscle. Lactate triggers muscle autophagy via K921 lactylation-dependent inactivation of ...
www.cell.com
November 12, 2025 at 4:33 PM
craigagoodman1.bsky.social
Tumour growth and chemotherapy alter skeletal muscle, cardiac, and hepatic amino acid pools in mice
journals.physiology.org/doi/abs/10.1...
Tumour growth and chemotherapy alter skeletal muscle, cardiac, and hepatic amino acid pools in mice | American Journal of Physiology-Cell Physiology | American Physiological Society
Background: Amino acids (AAs) play structural and metabolic roles in muscle, heart, and liver—tissues impacted by cancer and chemotherapy. Changes in AA profiles within these tissues have not been eva...
journals.physiology.org
November 11, 2025 at 4:33 PM
craigagoodman1.bsky.social
Alterations in peroxisome-mitochondria interplay in skeletal muscle accelerate muscle dysfunction
www.nature.com/articles/s41...
Alterations in peroxisome-mitochondria interplay in skeletal muscle accelerate muscle dysfunction - Nature Communications
The role of peroxisomes in skeletal muscle remains largely unexplored. Here, the authors show that peroxisomal dysfunction and disrupted crosstalk with mitochondria drive age-related muscle decline, u...
www.nature.com
November 10, 2025 at 8:39 PM
craigagoodman1.bsky.social
Establishment of normal myofiber size distribution in children and young adults
academic.oup.com/jnen/advance...
Establishment of normal myofiber size distribution in children and young adults
Abstract. Abnormalities of myofiber size are often of diagnostic significance on skeletal muscle biopsies, mainly when myofibers are excessively small. The
academic.oup.com
November 9, 2025 at 4:28 PM
craigagoodman1.bsky.social
Belt-type electrical muscle stimulation preserves muscle fiber size but does not improve muscle function in a rat model of cancer cachexia
journals.plos.org/plosone/arti...
Belt-type electrical muscle stimulation preserves muscle fiber size but does not improve muscle function in a rat model of cancer cachexia
Cancer cachexia causes severe muscle wasting, and current treatments remain limited. Belt-type electrical muscle stimulation (bEMS) has emerged as a passive rehabilitation tool capable of activating m...
journals.plos.org
November 7, 2025 at 6:48 PM
craigagoodman1.bsky.social
Dietary leucine intake and sarcopenia: from isolated supplementation to combined strategies
journals.lww.com/co-clinicaln...
journals.lww.com
November 7, 2025 at 6:47 PM
craigagoodman1.bsky.social
Myostatin deficiency blunts mechanical adaptation of soleus muscle to overload
link.springer.com/article/10.1...
Myostatin deficiency blunts mechanical adaptation of soleus muscle to overload - Journal of Muscle Research and Cell Motility
The aim of this study was to determine the impact of myostatin deficiency on the mechanical and contractile adaptations of the soleus muscle to functional overload (FO). Using a cross-sectional design...
link.springer.com
November 4, 2025 at 10:20 PM
craigagoodman1.bsky.social
Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture
rupress.org/jgp/article/...
Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture | Journal of General Physiology | Rockefeller University Press
Ex vivo muscle fiber cultures help scientists study skeletal muscle disease mechanisms, but long-term use causes structural decline and loss-of-function. V
rupress.org
November 4, 2025 at 10:19 PM
craigagoodman1.bsky.social
Sex differences in human skeletal muscle fiber types and the influence of age, physical activity, and muscle group: A systematic review and meta-analysis
physoc.onlinelibrary.wiley.com/doi/10.14814...
Sex differences in human skeletal muscle fiber types and the influence of age, physical activity, and muscle group: A systematic review and meta‐analysis
Systematic review and meta-analysis observing sex differences in fiber type size and composition. Shown are the number of studies identified through to the studies and number of males and females inc...
physoc.onlinelibrary.wiley.com
November 3, 2025 at 5:25 PM
craigagoodman1.bsky.social
Intracellular and Extracellular Redox Signals During Exercise and Aging
www.sciencedirect.com/science/arti...
Intracellular and Extracellular Redox Signals During Exercise and Aging
Regular physical activity enhances systemic health and resilience, partly through the generation of reactive oxygen species (ROS) that serve as key mo…
www.sciencedirect.com
November 1, 2025 at 6:00 PM
craigagoodman1.bsky.social
Muscle sparing through differential nutritional control of three muscle growth mechanisms: how zebrafish larvae deal with starvation
www.sciencedirect.com/science/arti...
Muscle sparing through differential nutritional control of three muscle growth mechanisms: how zebrafish larvae deal with starvation
How vertebrate skeletal muscle size is regulated and balanced with body size over the life-course is unclear, but is important for human health and qu…
www.sciencedirect.com
October 30, 2025 at 4:34 PM
craigagoodman1.bsky.social
Endocrine control of skeletal muscle regeneration and clinical applications
www.nature.com/articles/s41...
Endocrine control of skeletal muscle regeneration and clinical applications - Nature Reviews Endocrinology
Muscle regeneration relies on finely tuned hormonal signalling to regulate muscle stem cell activity. This Comment explores how anabolic, catabolic, metabolic and stress-related hormones influence mus...
www.nature.com
October 29, 2025 at 4:37 PM
craigagoodman1.bsky.social
The Brown Bear and Hibernating Mammals as a Translational Model for Human Resilience: Insights for Space Medicine, Critical Care, and Austere Environments
www.mdpi.com/2079-7737/14...
www.mdpi.com
October 29, 2025 at 4:35 PM
craigagoodman1.bsky.social
Molecular Framework of the Onset and Progression of Skeletal Muscle Aging
www.mdpi.com/1422-0067/26...
www.mdpi.com
October 29, 2025 at 4:35 PM
craigagoodman1.bsky.social
NSAID ingestion augments training-induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com
October 27, 2025 at 8:11 PM
craigagoodman1.bsky.social
Brown adipose tissue and skeletal muscle coordinately contribute to thermogenesis in mice
elifesciences.org/articles/99982
Brown adipose tissue and skeletal muscle coordinately contribute to thermogenesis in mice
Muscle-derived branched-chain amino acids support thermogenesis in brown adipose tissue, thereby helping maintain body temperature during impaired muscle function or physiological stress.
elifesciences.org
October 27, 2025 at 8:10 PM
craigagoodman1.bsky.social
Cachexia progression differs among mouse models of metastatic triple-negative breast cancer
journals.physiology.org/doi/full/10....
Cachexia progression differs among mouse models of metastatic triple-negative breast cancer | American Journal of Physiology-Cell Physiology | American Physiological Society
Cancer-associated cachexia decreases the quality of life, reduces therapy response, and diminishes survival prospects. Effective cachexia countermeasures remain a significant unmet need. Research into...
journals.physiology.org
October 25, 2025 at 5:56 PM
craigagoodman1.bsky.social
Estrogen Receptor Regulates Male Satellite Cells in a Female, but Not Male, Environment
www.mdpi.com/2073-4409/14...
www.mdpi.com
October 23, 2025 at 11:23 PM
craigagoodman1.bsky.social
Lysosomal damage is a therapeutic target in Duchenne muscular dystrophy
www.science.org/doi/10.1126/...
Lysosomal damage is a therapeutic target in Duchenne muscular dystrophy
Lysosomal damage contributes to DMD pathology and is a therapeutic target worth considering for current and future approaches.
www.science.org
October 23, 2025 at 4:38 PM
craigagoodman1.bsky.social
Lamin A/C protects chromatin accessibility during mechanical loading in human skeletal muscle
biosignaling.biomedcentral.com/articles/10....
Lamin A/C protects chromatin accessibility during mechanical loading in human skeletal muscle - Cell Communication and Signaling
Background Skeletal muscle nuclei (myonuclei) are subjected to high mechanical stress which plays a critical role in muscle tissue integrity and plasticity. Here we investigated the role of lamin A/C ...
biosignaling.biomedcentral.com
October 23, 2025 at 4:36 PM
craigagoodman1.bsky.social
Dynamic time course of muscle proteome adaptation to programmed resistance training in rats

journals.physiology.org/doi/abs/10.1...
Dynamic time course of muscle proteome adaptation to programmed resistance training in rats | American Journal of Physiology-Cell Physiology | American Physiological Society
Resistance training promotes muscle protein accretion and myofiber hypertrophy, driven by dynamic processes of protein synthesis and degradation. Muscle adaptations to on going resistance training occ...
journals.physiology.org
October 22, 2025 at 4:33 PM
craigagoodman1.bsky.social
Estrogen in skeletal muscle: metabolism, mechanisms, and exercise-induced changes
link.springer.com/article/10.1...
Estrogen in skeletal muscle: metabolism, mechanisms, and exercise-induced changes - Journal of Endocrinological Investigation
With the intensification of population aging, issues such as age-related skeletal muscle loss and metabolic disorders have garnered increasing attention. As the menopausal transition progresses, circu...
link.springer.com
October 22, 2025 at 4:31 PM