Christopher P Jones
@cpricejones.bsky.social
RNA structure geek using X-ray crystallography and cryoEM, unknown soldier in a doomed battle against barbarism
Trees in our backyard blooming 😍😍
March 31, 2025 at 11:34 PM
Trees in our backyard blooming 😍😍
#RNA crystals over the years #crystallography
First real RNA crystals I ever obtained, a shower of plates
First real RNA crystals I ever obtained, a shower of plates
February 9, 2025 at 4:58 PM
#RNA crystals over the years #crystallography
First real RNA crystals I ever obtained, a shower of plates
First real RNA crystals I ever obtained, a shower of plates
#RNA crystals over the years #crystallography
Buttery U1A crystals found ~8 months after setting up trays, going to 1.6-1.7 Å
Buttery U1A crystals found ~8 months after setting up trays, going to 1.6-1.7 Å
February 8, 2025 at 4:57 PM
#RNA crystals over the years #crystallography
Buttery U1A crystals found ~8 months after setting up trays, going to 1.6-1.7 Å
Buttery U1A crystals found ~8 months after setting up trays, going to 1.6-1.7 Å
February 7, 2025 at 5:56 PM
February 6, 2025 at 5:55 PM
#RNA crystals over the years #crystallography
Prism growing on a highly concentrated phase or precipitate
Prism growing on a highly concentrated phase or precipitate
February 5, 2025 at 6:54 PM
#RNA crystals over the years #crystallography
Prism growing on a highly concentrated phase or precipitate
Prism growing on a highly concentrated phase or precipitate
#RNA crystals over the years #crystallography
Rectangular prisms going to 4 Å … so close yet so far away
Rectangular prisms going to 4 Å … so close yet so far away
February 4, 2025 at 5:53 PM
#RNA crystals over the years #crystallography
Rectangular prisms going to 4 Å … so close yet so far away
Rectangular prisms going to 4 Å … so close yet so far away
#RNA crystals over the years #crystallography
SARS-CoV-2 PK: stunning prisms that poorly diffracted, even after many attempts of treatment and ideal growth optimization
SARS-CoV-2 PK: stunning prisms that poorly diffracted, even after many attempts of treatment and ideal growth optimization
February 3, 2025 at 6:47 PM
#RNA crystals over the years #crystallography
SARS-CoV-2 PK: stunning prisms that poorly diffracted, even after many attempts of treatment and ideal growth optimization
SARS-CoV-2 PK: stunning prisms that poorly diffracted, even after many attempts of treatment and ideal growth optimization
#RNA crystals over the years #crystallography
Bizarre bundle of crystals, one apparently sending out feelers to the other
Bizarre bundle of crystals, one apparently sending out feelers to the other
February 2, 2025 at 6:48 PM
#RNA crystals over the years #crystallography
Bizarre bundle of crystals, one apparently sending out feelers to the other
Bizarre bundle of crystals, one apparently sending out feelers to the other
#RNA crystals over the years #crystallography
SARS-CoV-2 PK: looks can be deceiving, as these diffracted poorly
SARS-CoV-2 PK: looks can be deceiving, as these diffracted poorly
February 1, 2025 at 6:48 PM
#RNA crystals over the years #crystallography
SARS-CoV-2 PK: looks can be deceiving, as these diffracted poorly
SARS-CoV-2 PK: looks can be deceiving, as these diffracted poorly
January 31, 2025 at 6:48 PM
#RNA crystals over the years #crystallography
RSV PK: happy rods poking out of a phase, requiring mechanical separation, 2.7 Å with two different structures from one asymmetric unit aka magical Christmas land
RSV PK: happy rods poking out of a phase, requiring mechanical separation, 2.7 Å with two different structures from one asymmetric unit aka magical Christmas land
January 30, 2025 at 6:47 PM
#RNA crystals over the years #crystallography
RSV PK: happy rods poking out of a phase, requiring mechanical separation, 2.7 Å with two different structures from one asymmetric unit aka magical Christmas land
RSV PK: happy rods poking out of a phase, requiring mechanical separation, 2.7 Å with two different structures from one asymmetric unit aka magical Christmas land
#RNA crystals over the years #crystallography
SARS-CoV-2 SL5: iridium soaked crystals for phasing, flat edge was attached to the cover slip, diffracting to ~3.5 Å after dehydrating in 1.4-1.6 M citrate 😬 that liked to precipitate during looping, phases were outstanding despite resolution
SARS-CoV-2 SL5: iridium soaked crystals for phasing, flat edge was attached to the cover slip, diffracting to ~3.5 Å after dehydrating in 1.4-1.6 M citrate 😬 that liked to precipitate during looping, phases were outstanding despite resolution
January 29, 2025 at 6:47 PM
#RNA crystals over the years #crystallography
SARS-CoV-2 SL5: iridium soaked crystals for phasing, flat edge was attached to the cover slip, diffracting to ~3.5 Å after dehydrating in 1.4-1.6 M citrate 😬 that liked to precipitate during looping, phases were outstanding despite resolution
SARS-CoV-2 SL5: iridium soaked crystals for phasing, flat edge was attached to the cover slip, diffracting to ~3.5 Å after dehydrating in 1.4-1.6 M citrate 😬 that liked to precipitate during looping, phases were outstanding despite resolution
#RNA crystals over the years #crystallography
SARS-CoV-2: gnarly needles that surprisingly went to 2.2 Å. Dehydration pushed them to 1.2 Å 😳, the best RNA crystals I’ve had by far, first time doing anisotropic B factor refinement
SARS-CoV-2: gnarly needles that surprisingly went to 2.2 Å. Dehydration pushed them to 1.2 Å 😳, the best RNA crystals I’ve had by far, first time doing anisotropic B factor refinement
January 28, 2025 at 6:47 PM
#RNA crystals over the years #crystallography
SARS-CoV-2: gnarly needles that surprisingly went to 2.2 Å. Dehydration pushed them to 1.2 Å 😳, the best RNA crystals I’ve had by far, first time doing anisotropic B factor refinement
SARS-CoV-2: gnarly needles that surprisingly went to 2.2 Å. Dehydration pushed them to 1.2 Å 😳, the best RNA crystals I’ve had by far, first time doing anisotropic B factor refinement
#RNA crystals over the years #crystallography
SARS-CoV-2 PK: crystals proving once and for all that, yes, SARS is a dick
Alas, poorly diffracting form though
SARS-CoV-2 PK: crystals proving once and for all that, yes, SARS is a dick
Alas, poorly diffracting form though
January 27, 2025 at 6:47 PM
#RNA crystals over the years #crystallography
SARS-CoV-2 PK: crystals proving once and for all that, yes, SARS is a dick
Alas, poorly diffracting form though
SARS-CoV-2 PK: crystals proving once and for all that, yes, SARS is a dick
Alas, poorly diffracting form though
January 27, 2025 at 4:42 PM
#RNA crystals over the years #crystallography
Cbe ZTP riboswitch: chonky crystals that looked pretty, but that’s about it … poorly diffracting form
Cbe ZTP riboswitch: chonky crystals that looked pretty, but that’s about it … poorly diffracting form
January 26, 2025 at 6:46 PM
#RNA crystals over the years #crystallography
Cbe ZTP riboswitch: chonky crystals that looked pretty, but that’s about it … poorly diffracting form
Cbe ZTP riboswitch: chonky crystals that looked pretty, but that’s about it … poorly diffracting form
#RNA crystals over the years #crystallography
Cbe ZTP riboswitch: mm long thin rods, poorly diffracting form
Cbe ZTP riboswitch: mm long thin rods, poorly diffracting form
January 25, 2025 at 6:46 PM
#RNA crystals over the years #crystallography
Cbe ZTP riboswitch: mm long thin rods, poorly diffracting form
Cbe ZTP riboswitch: mm long thin rods, poorly diffracting form
#RNA crystals over the years #crystallography
Cbe ZTP riboswitch: Crystal with an inclusion, poorly diffracting form
Cbe ZTP riboswitch: Crystal with an inclusion, poorly diffracting form
January 24, 2025 at 6:46 PM
#RNA crystals over the years #crystallography
Cbe ZTP riboswitch: Crystal with an inclusion, poorly diffracting form
Cbe ZTP riboswitch: Crystal with an inclusion, poorly diffracting form
#RNA crystals over the years #crystallography
Cbe ZTP riboswitch: growing from a phase, one of many crystal forms obtained and best diffracting (~2.5 Å), phased with Cs, which caused a loop to change conformations slightly
Cbe ZTP riboswitch: growing from a phase, one of many crystal forms obtained and best diffracting (~2.5 Å), phased with Cs, which caused a loop to change conformations slightly
January 23, 2025 at 6:46 PM
#RNA crystals over the years #crystallography
Cbe ZTP riboswitch: growing from a phase, one of many crystal forms obtained and best diffracting (~2.5 Å), phased with Cs, which caused a loop to change conformations slightly
Cbe ZTP riboswitch: growing from a phase, one of many crystal forms obtained and best diffracting (~2.5 Å), phased with Cs, which caused a loop to change conformations slightly
#RNA crystals over the years #crystallography
ZTP riboswitch: ordered plasmid in Feb, phased by March, peaceful easygoing crystals, if only slightly better than 3 Å
ZTP riboswitch: ordered plasmid in Feb, phased by March, peaceful easygoing crystals, if only slightly better than 3 Å
January 22, 2025 at 6:46 PM
#RNA crystals over the years #crystallography
ZTP riboswitch: ordered plasmid in Feb, phased by March, peaceful easygoing crystals, if only slightly better than 3 Å
ZTP riboswitch: ordered plasmid in Feb, phased by March, peaceful easygoing crystals, if only slightly better than 3 Å
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
20/20
20/20
January 22, 2025 at 5:02 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
20/20
20/20
#RNA crystals over the years #crystallography
C-di-AMP riboswitch: my first structure, second crystal form, plates requiring manual separation with cat whiskers; shot ~1000 crystals in the project and only ~10 were better than 3.5-4 Å
C-di-AMP riboswitch: my first structure, second crystal form, plates requiring manual separation with cat whiskers; shot ~1000 crystals in the project and only ~10 were better than 3.5-4 Å
January 21, 2025 at 6:45 PM
#RNA crystals over the years #crystallography
C-di-AMP riboswitch: my first structure, second crystal form, plates requiring manual separation with cat whiskers; shot ~1000 crystals in the project and only ~10 were better than 3.5-4 Å
C-di-AMP riboswitch: my first structure, second crystal form, plates requiring manual separation with cat whiskers; shot ~1000 crystals in the project and only ~10 were better than 3.5-4 Å
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
19/20
19/20
January 21, 2025 at 5:02 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
19/20
19/20
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
18/20
18/20
January 20, 2025 at 5:02 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
18/20
18/20