Centre for Programmable Biological Matter
@cpbm-heddlelab.bsky.social
At the CPBM, we are interested in understanding, designing and building natural and artificial bionanomachines. Located at Durham University, funded by The Leverhulme Trust and Academy of Medical Sciences.
Read more here: www.tandfonline.com/doi/full/10....
@durham-university.bsky.social #RNABiology #Research #Innovation
@durham-university.bsky.social #RNABiology #Research #Innovation
Mechanistic insight into the pseudouridylation of RNA
Pseudouridylation (Ψ) is a highly abundant and conserved RNA modification that is present in all three domains of life. The incorporation of Ψ can affect the stability of RNAs, modulate their inter...
www.tandfonline.com
August 15, 2025 at 10:04 AM
This work demonstrated enhanced stability and certain structural changes in four human tRNAs before, and after, the incorporation of pseudouridine (Ψ).
Read more here: www.embopress.org/doi/full/10....
#RNA #tRNA #MolecularBiology
Read more here: www.embopress.org/doi/full/10....
#RNA #tRNA #MolecularBiology
Determining the effects of pseudouridine incorporation on human tRNAs | The EMBO Journal
imageimagetRNAs harbour a complex set of modifications which are important for their function.
Here, single particle cryo-EM, biophysics, and computational analyses of the effects
of pseudouridine inc...
www.embopress.org
July 4, 2025 at 2:37 PM
This work demonstrated enhanced stability and certain structural changes in four human tRNAs before, and after, the incorporation of pseudouridine (Ψ).
Read more here: www.embopress.org/doi/full/10....
#RNA #tRNA #MolecularBiology
Read more here: www.embopress.org/doi/full/10....
#RNA #tRNA #MolecularBiology
Interested in sharing your work at a future session? Get in touch today: lucy.epton@durham.ac.uk
April 23, 2025 at 1:51 PM
Interested in sharing your work at a future session? Get in touch today: lucy.epton@durham.ac.uk
Read the full article here: onlinelibrary.wiley.com/doi/full/10....
Designed, Programmable Protein Cages Utilizing Diverse Metal Coordination Geometries Show Reversible, pH‐Dependent Assembly
A hyperstable artificial protein cage can be disassembled on demand under specific conditions such as pH below 7. The cage reassembles when conditions are reversed.
onlinelibrary.wiley.com
April 15, 2025 at 11:08 AM
Read the full article here: onlinelibrary.wiley.com/doi/full/10....