Trends in Biochemical Sciences
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cp-trendsbiochem.bsky.social
Trends in Biochemical Sciences
@cp-trendsbiochem.bsky.social
TIBS is celebrating its 50th anniversary in 2026 - join in the fun and share your ideas with us!

To learn more, visit: https://www.cell.com/trends/biochemical-sciences/anniversary

Managed by editor @sanniejculbertson.bsky.social
Primary @cp-cell.bsky.social article: "Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures" from Guang-Hui Liu and colleagues.

Read it here: www.sciencedirect.com/science/arti...
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures
Proteins are the cornerstone of life. However, the proteomic blueprint of aging across human tissues remains uncharted. Here, we present a comprehensi…
www.sciencedirect.com
November 18, 2025 at 9:36 PM
💡 A Spotlight from Wagner Araujo et al describing recent research on mitoproteomics
📝 A Forum on the cGAS-STING pathway and lysosome from Wei Wan et al
🔬 A Technology of the Month on characterizing #glycoRNAs from Yuan Ma et al

(5/5)
November 14, 2025 at 2:48 PM
Want even more? Then check out:
🥼 A Scientific Life from @jestsai.bsky.social et al on implementing a daily standup meeting for #accountability and #psycholocialsafety
💡 A Spotlight from @goemanslab.bsky.social highlighting work on defluorination activity in gut microbiota

(4/n)
November 14, 2025 at 2:47 PM
Don't miss out on other great Reviews!
📝 The role membranes play in #Huntington's disease is Reviewed by Justin Legleiter
📝 Sebastian Glatt et al Review how #RNAmodifications in ribosomes can be mapped to high resolution

(3/n)
November 14, 2025 at 2:46 PM
Don't miss out on other great Reviews!
📝 A Review from Shaun Olsen et al on #E3Ligases in signaling and therapeutics
📝 A Review from Joseph Cotruvo et al characterizing #Lanthanide biochemistry
📝 Ana Garcia-Saez et al Review the central role mitochondrial membranes play in cell death pathways
(2/n)
November 14, 2025 at 2:44 PM
(2/2) @natchembio.nature.com - "Highly specific intracellular ubiquitination of a small molecule" from Jonathan Ostrem and colleagues: www.nature.com/articles/s41...
Highly specific intracellular ubiquitination of a small molecule - Nature Chemical Biology
Li et al. discovered that the cytotoxic synthetic small molecule BRD1732 is directly ubiquitinated in cells. Ubiquitination of BRD1732 is E3 ligase dependent and leads to inhibition of proteasomal deg...
www.nature.com
October 30, 2025 at 12:48 PM
Primary articles being highlighted:
(1/2) @natcomms.nature.com - "Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1" from Sonja Lorenz and colleagues: www.nature.com/articles/s41...
Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1 - Nature Communications
Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule substrates, beyond proteins. This di...
www.nature.com
October 30, 2025 at 12:48 PM