Massive thanks to @bcrt-uk.bsky.social for funding this project with an Ideas Grant, and @cflabsresearch.bsky.social for the PDX work. @ucl.ac.uk

We identify EPRS inhibitors as a promising approach for chordoma, triggering an ATF4-mediated stress response and pro-apoptotic cell death: the compound Halofuginone significantly reduces tumor growth in PDX models.