Congrats Alexis! Fantastic news and well deserved 🎉

Some repeats and structure-forming sequences are indeed difficult to clone, not because they are toxic, but because they are genetically unstable. Examples are AT and CGG repeats. If a sequence is problematic, cloning efficiency will be low, but clones you do get will have deletions in that area.

Are you having issues with a plasmid or are you trying to introduce a toxic sequence on purpose?

🎉 Congrats Mathew and Mike! Great to finally see this out. A fantastic tool for the replication community and beyond 👏

Congrats Hasan. Well deserved 🎉😁

Very cool to see MCM loading in action and with such detail. Years of genetic, biochemical and structural work from many labs distilled into a beautiful animation 🧬👍

Congrats Stephen 🎉🎉🎉

Congrats Puck and Koichi 🎉 Super exciting G4 biology 🧬

Congrats Tanmay 🎉🎉

Congrats Dirk and team! Great work and good to finally see it out!

Congrats Alessandro!

Thanks Francesca!

Thanks Christian!

Thanks Alessandro!

Thanks Annabel!