5/ Thanks to all for diving into this debate on diabetes drugs!

Authors: @shreyatrivedimd.bsky.social, Dr. Tracy Rabin, Dr. Kenneth Fifer and Dr. Cary Blum

Graphic: Amy Mu

Audio: Kathreene Gala

4/ SGLTis are best for:

🍬 Patients with HFrEF/HFpEF or CKD
🍬 ASCVD or high CV risk
🍬 Patients prioritizing oral route
🍬 Patients w/ “a little bit of everything”
🍬 A1C lowering is not priority

3/ GLP1RAs are best for:

🍬 Patients with obesity
🍬 Established ASCVD
🍬 Needing dual benefit: glucose + weight control
🍬 Proteinuric diabetic kidney disease already on ACE/ARB & SGLT2i

2/ Metformin is best for:

🍬 Overweight patients with no ASCVD or HF
🍬 Budget-conscious patients
🍬 Initial therapy in most patients

2/ Thanks, Dr. Stephen Cooper!

TRUE ‼️

Use this handy chart to remember conversions and glucocorticoid/mineralocorticoid activity of steroids!

www.coreimpodcast.com/2023/06/28/s...

7/ Thanks to all!

Authors: @shreyatrivedimd.bsky.social @noahmarkewitz11.bsky.social Dr. Yaling Tang

Experts: Dr. Juan Carlos Q. Velez, Dr. Nikhilesh Mazumder, Dr. Marina Serper

Graphic: Dr. Dexter Nwachukwu

Peer Reviewers: Dr. Justin Belcher and @ebtapper.bsky.social

Audio: Kathreene Gala

6/ Palliative care?

🫘 The❓is whether to do chronic dialysis knowing it won’t ⬇️ the liver disease
🫘 W/ dialysis: expected lifespan is a few months
🫘 W/out dialysis: expected lifespan is days-weeks
🫘 BP may too ⬇️ for dialysis

💡 Early palliative care involvement is best

5/ Transplant?

🫘 Dialysis can act as a bridge to transplant 
🫘 Liver transplant is based off MELD 3.0
🫘 To be considered for simultaneous Liver Kidney transplant must be on dialysis for 6+ weeks, or have a GFR < 60 for at least 90 days prior to dialysis start

4/ Diuretics:

💡 “No BP no PP”

🫘 Before managing volume, first raise the MAP ‼️
🫘 Diuretics may raise Cr mildly, but acceptable if patient is improving clinically

3/ Albumin:

🫘 Only given to bring patients to euvolemia

💡 A main side effect of CONFIRM was respiratory compromise by giving repeated doses of albumin

2/ Vasoconstrictors:

1️⃣ Terlipressin
- CONFIRM trial
- Contraindications: Cr > 5, MELD > 35, ACLF grade 3, volume overload, or active ischemia
2️⃣ Norepinephrine
3️⃣ Midodrine, octreotide
- Usually only given if contraindications to terlipressin

Amazing episode, thanks @juancarlosqvelez.bsky.social @coreimpodcast.bsky.social and crew!

Something I've always struggled with below. Appreciate any insights!

7/ Thanks to all!

Authors: @shreyatrivedimd.bsky.social @noahmarkewitz11.bsky.social Dr. Yaling Tang

Experts: Dr. Juan Carlos Q. Velez, Dr. Nikhilesh Mazumder, Dr. Marina Serper

Graphic: Dr. Dexter Nwachukwu

Peer Reviewers: Dr. Justin Belcher and @ebtapper.bsky.social

6/ Stay tuned for part ✌️