I saw an article about prion disease a few years ago; a discussion on chronic wasting disease in North American deer populations.
It's just niche - treatment is limited to supportive care in humans and euthanasia in animals. My college texts in bio and biochem spent less than a page total on this.

Full agreement, I appreciate your perspective here. It's a disservice to beneficiaries/patients that off-label but well-studied interventions require peer-to-peer appeals to even get close to having claims approved.

Excellent work, congrats to your teams and thank you for sharing! Q: given the very high bioavailability through IM route (93%) -- do you see that as a viable alternative to IV administration? Would certainly expand its use. #medsky

I probably won't be back on here for a while until I get more of a solid flow. My priority is being a good golden retriever in a button up so I'm avoiding instant gratification social media until I can trust that I'm taking care of the stuff that really matters. Hope all the bsky peeps are well.

I have started using the Building a Second Brain method touted by Tiago Forte to (incremental but noticable) success. Fuck you, ADHD -- thanks Apple Notes.

My wife and unborn daughter are well. Still some nausea, malaise, and bloating present, but the second trimester is going well.

Hopefully nobody since this was concept art by an independent artist

That communion grape juice be hittin 🥴

Working night shift was a saving grace for me. When I have to join the living, I result to caffeine and self-deprecating jokes about how tired I am.

The question for clinicians: use shorter durations or accept renal dysfunction risk?
A patient with kidney disease could still benefit from remdesivir for severe COVID19, or posaconazole for certain fungal infections. More on excipients' toxicities tomorrow.

Cyclodextrin, a ring of carbohydrates shaped like a barrel, interacts with poorly soluble drugs & water, solubilizing stubborn drugs. But it accumulates in impaired renal function, risking further renal impairment.

Between Death Grips and the Danny Brown x JPEGMAFIA collab, I put the “*harm” in “pharmacy”

*it’s a bad pun, I just like leftfield hip hop