Thanks indeed to all program officers and grant manager specialists at the NIH. I admire their resilience and commitment to keeping the NIH as the best science funding agency in the world even when tehm are under assault by the administration. It is clear who is on the side of Science and who is not

I am disappointed and alarmed that millions of Americans listen to these comments and do not see anything fundamentally wrong and indicative of a psychopathy.

This is important, among other reasons, because ICIs failed in relapsed ovarian cancers, questioning whether relapsed tumors lost immunogenicity.
Although analyses of neoantigens and TCR frequencies are ongoing, it is clear that tumors re-establish the immuno-environment (e.g., TIL patterns).

There is at least some attention from the press to the devastation of the scientific enterprise that is going on...

Trump Seeks to Cut Basic Scientific Research by Roughly One-Third, Report Shows www.nytimes.com/2025/07/10/s...

In immunology, for instance, experiments can only be done in vivo to capture the complex interactions of multiple cell types, cytokines and chemokines. No computer will predict immune subsets and mediators that we do not fully understand yet.

They did not need to delay the progress of biomedical research for many years, ruining the life of thousands of valuable people in the process, to find that people mostly work in government because they believe in the mission of the agency. Very efficiently for what they earn