@colinbbegg.bsky.social
Over-volunteering in phase I clinical trials by healthy volunteers presents risks. Roberto Abadie and colleagues advocate the use of national registries, as implemented in France, Malaysia and the UK, to offset this problem. @hastingscenter.bsky.social @uw-medicine.bsky.social
October 23, 2025 at 5:04 PM
Over-volunteering in phase I clinical trials by healthy volunteers presents risks. Roberto Abadie and colleagues advocate the use of national registries, as implemented in France, Malaysia and the UK, to offset this problem. @hastingscenter.bsky.social @uw-medicine.bsky.social
Caregiver perspectives on clinical trials and roles in patient enrollment decisions remain understudied. This review assessed the state of current research on caregiver roles in cancer trial enrollment decision-making. @hastingscenter.bsky.social
October 23, 2025 at 4:52 PM
Caregiver perspectives on clinical trials and roles in patient enrollment decisions remain understudied. This review assessed the state of current research on caregiver roles in cancer trial enrollment decision-making. @hastingscenter.bsky.social
Aitana Juan-Giner review informed consent practices in vaccine clinical trials in sub-Saharan Africa, concluding that lack of understanding can lead to confusion and suspicion. @isglobal.bsky.social ic-matters.bsky.social
October 23, 2025 at 4:35 PM
Aitana Juan-Giner review informed consent practices in vaccine clinical trials in sub-Saharan Africa, concluding that lack of understanding can lead to confusion and suspicion. @isglobal.bsky.social ic-matters.bsky.social
Determining cause of death is crucial for studying disease free survival in clinical trials. Mark Nelson and colleagues conducted a validation study in Australia to see if the costs of adjudication panels are warranted. @utas.edu.au
October 23, 2025 at 3:42 PM
Determining cause of death is crucial for studying disease free survival in clinical trials. Mark Nelson and colleagues conducted a validation study in Australia to see if the costs of adjudication panels are warranted. @utas.edu.au
Through hands-on mentorship, real-world placements, and comprehensive curriculum, the CANSTAT network aims to train a generation of biostatistics experts who will strengthen Canada's clinical trial capacity and improve health outcomes. @machealthsci.bsky.social @parpia.bsky.social
October 23, 2025 at 3:21 PM
Through hands-on mentorship, real-world placements, and comprehensive curriculum, the CANSTAT network aims to train a generation of biostatistics experts who will strengthen Canada's clinical trial capacity and improve health outcomes. @machealthsci.bsky.social @parpia.bsky.social
Tra My Pham and colleagues address the IHC E9 (R1) addendum on intercurrent events in clinical trials, showing how to align estimators for commonly used analytic techniques. @mrcctu.bsky.social @lshtm.bsky.social
October 23, 2025 at 3:07 PM
Tra My Pham and colleagues address the IHC E9 (R1) addendum on intercurrent events in clinical trials, showing how to align estimators for commonly used analytic techniques. @mrcctu.bsky.social @lshtm.bsky.social
Susan Halabi and colleagues advocate a Bayesian study design for integrating data from multiple basket trials for studying rare cancers. @duke-university.bsky.social @DukeMedSchool.bsky.social
October 23, 2025 at 2:46 PM
Susan Halabi and colleagues advocate a Bayesian study design for integrating data from multiple basket trials for studying rare cancers. @duke-university.bsky.social @DukeMedSchool.bsky.social
Aryelly Rodriguez and colleagues have studied publicly available de-identified clinical trial datasets and have evaluated the risks of identification of individuals via a risk score. @edinburgh-uni.bsky.social
October 23, 2025 at 2:31 PM
Aryelly Rodriguez and colleagues have studied publicly available de-identified clinical trial datasets and have evaluated the risks of identification of individuals via a risk score. @edinburgh-uni.bsky.social
Clare Bailey and colleagues document the time savings for clinical research staff due to automatic retrieval of data from the electronic medical records in the VOYAGER clinical trial. @bristoluni.bsky.social
October 23, 2025 at 2:16 PM
Clare Bailey and colleagues document the time savings for clinical research staff due to automatic retrieval of data from the electronic medical records in the VOYAGER clinical trial. @bristoluni.bsky.social
How good are GenAI algorithms at writing clinical trial documents? Nigel Markey and colleagues show how to set up GenAI algorithms successfully.
August 1, 2025 at 7:14 PM
How good are GenAI algorithms at writing clinical trial documents? Nigel Markey and colleagues show how to set up GenAI algorithms successfully.
A study by Maryam Mooghali and colleagues at the Yale CRRIT found that the CMS Coverage with Evidence Development program has successfully prompted generation of more robustly designed clinical studies to better inform clinical, regulatory, and coverage decisions.
August 1, 2025 at 6:48 PM
A study by Maryam Mooghali and colleagues at the Yale CRRIT found that the CMS Coverage with Evidence Development program has successfully prompted generation of more robustly designed clinical studies to better inform clinical, regulatory, and coverage decisions.
It’s time we had discipline-specific education to create a job-ready clinical trial workforce with professional recognition. Simone Spark and colleagues outline an education and accreditation strategy for current and future clinical trialists. @monashuniversity.bsky.social
August 1, 2025 at 6:02 PM
It’s time we had discipline-specific education to create a job-ready clinical trial workforce with professional recognition. Simone Spark and colleagues outline an education and accreditation strategy for current and future clinical trialists. @monashuniversity.bsky.social
Research conducted by Laura Doherty and colleagues at the York Trials Unit suggests that sending participant SMS reminders may positively impact participant retention in clinical trials.
August 1, 2025 at 5:49 PM
Research conducted by Laura Doherty and colleagues at the York Trials Unit suggests that sending participant SMS reminders may positively impact participant retention in clinical trials.
The PeRSEVERE principles guide all involved in trials through potential challenges of managing withdrawal/other participation changes. This new paper describes the development process that led to the principles, and explores the principles' implications @LeedsCTRU.bsky.social@willjcragg.bsky.social
August 1, 2025 at 5:38 PM
The PeRSEVERE principles guide all involved in trials through potential challenges of managing withdrawal/other participation changes. This new paper describes the development process that led to the principles, and explores the principles' implications @LeedsCTRU.bsky.social@willjcragg.bsky.social
Megan Othus and colleagues examine how differential timing of outcome assessments in randomized trials can affect study validity. @SWOG.org @fredhutch.bsky.social
August 1, 2025 at 5:23 PM
Megan Othus and colleagues examine how differential timing of outcome assessments in randomized trials can affect study validity. @SWOG.org @fredhutch.bsky.social
Yu Zheng and colleagues explore the heterogeneity of treatment effect in an HIV clinical trial with a view to fulfilling the promise of precision medicine. #clinicaltrials #precisionmedicine #publichealth #ACTG #HIV
August 1, 2025 at 4:51 PM
Yu Zheng and colleagues explore the heterogeneity of treatment effect in an HIV clinical trial with a view to fulfilling the promise of precision medicine. #clinicaltrials #precisionmedicine #publichealth #ACTG #HIV
Joshua Nugent and colleagues address the challenges of analyzing randomized trials where clustering due to dependence between participants occurs only for some groups of participants, offering estimation strategies. @kaiseer-permanente.bsky.social
August 1, 2025 at 4:44 PM
Joshua Nugent and colleagues address the challenges of analyzing randomized trials where clustering due to dependence between participants occurs only for some groups of participants, offering estimation strategies. @kaiseer-permanente.bsky.social
A systematic error in bone density scans in the DCCT/EDIC study led to incorrect classifications, prompting a quality assurance review. Reanalysis corrected diagnoses and ensured patient safety. This framework offers a model for future clinical trials. @UCSanDiego.bsky.social
August 1, 2025 at 3:10 PM
A systematic error in bone density scans in the DCCT/EDIC study led to incorrect classifications, prompting a quality assurance review. Reanalysis corrected diagnoses and ensured patient safety. This framework offers a model for future clinical trials. @UCSanDiego.bsky.social
Xiayan Chen and colleagues provide details of how to conduct dietary intervention clinical trials with the goal of optimizing study validity. @pku1898.bsky.social
July 30, 2025 at 8:36 PM
Xiayan Chen and colleagues provide details of how to conduct dietary intervention clinical trials with the goal of optimizing study validity. @pku1898.bsky.social
Faye Williamson and colleagues propose a new method for calculating the sample size for a cluster randomized clinical trial that limits uncertainty about the ICC. @newcastleuni.bsky.social
July 30, 2025 at 8:28 PM
Faye Williamson and colleagues propose a new method for calculating the sample size for a cluster randomized clinical trial that limits uncertainty about the ICC. @newcastleuni.bsky.social
John Cleland and Danyaal Anzar provide a highly critical commentary on the Wittes et al. article. #FAU @uofglasgow.bsky.social
June 23, 2025 at 8:30 PM
John Cleland and Danyaal Anzar provide a highly critical commentary on the Wittes et al. article. #FAU @uofglasgow.bsky.social
A group of experts led by Janet Wittes revisit the influential ASPREE clinical trial, strongly criticizing how it was reported and its influence on guidelines for use of aspirin in disease prevention. #FAU
June 23, 2025 at 8:26 PM
A group of experts led by Janet Wittes revisit the influential ASPREE clinical trial, strongly criticizing how it was reported and its influence on guidelines for use of aspirin in disease prevention. #FAU
Using data from the ACTT COVID trial Bonnett, Potter and Dodd simulate the impact on type 1 error of using non-concurrent controls in platform trials with secular trends in outcome. @niaidnews.bsky.social
June 23, 2025 at 8:17 PM
Using data from the ACTT COVID trial Bonnett, Potter and Dodd simulate the impact on type 1 error of using non-concurrent controls in platform trials with secular trends in outcome. @niaidnews.bsky.social
Kamil Malshy and colleagues recount the long and influential history of the military in clinical trials, all the way from King Nebucchadnezzar, through James Lind with the British navy, to recent wars in Iraq and Afghanistan.
June 23, 2025 at 8:11 PM
Kamil Malshy and colleagues recount the long and influential history of the military in clinical trials, all the way from King Nebucchadnezzar, through James Lind with the British navy, to recent wars in Iraq and Afghanistan.