Charles Mullighan
@cmullighan.bsky.social
Haematologist/Haematopathologist ex Adelaide advancing understanding and cures of leukemia at St. Jude Children's Research Hospital.
Our preprint led by Nicole Michmerhuizen and Emily Heikamp showing the key role and targetability of the MOZ/MORF history acetyltransferases in high-risk NUP98-rearranged acute myeloid leukemia.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia
NUP98 fusion oncoproteins (FOs) are a hallmark of childhood acute myeloid leukemia (AML) and drive leukemogenesis through liquid-liquid phase separation-mediated nuclear condensate formation. However,...
www.biorxiv.org
December 9, 2024 at 6:14 PM
Our preprint led by Nicole Michmerhuizen and Emily Heikamp showing the key role and targetability of the MOZ/MORF history acetyltransferases in high-risk NUP98-rearranged acute myeloid leukemia.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Glad to share the work of the fantastic Cancer Biomarkers Laboratory of St Jude showing the power and utility of cell free genomic analysis to detect diverse genomic variants in leukemia and many solid tumors. Exciting potential for mutation-specific monitoring. www.nature.com/articles/s41...
Genomic profiling of circulating tumor DNA for childhood cancers - Leukemia
Leukemia - Genomic profiling of circulating tumor DNA for childhood cancers
www.nature.com
November 20, 2024 at 8:26 PM
Glad to share the work of the fantastic Cancer Biomarkers Laboratory of St Jude showing the power and utility of cell free genomic analysis to detect diverse genomic variants in leukemia and many solid tumors. Exciting potential for mutation-specific monitoring. www.nature.com/articles/s41...