Centre for Medicines Discovery
@cmd.ox.ac.uk
A multi-disciplinary Institute within the University of Oxford which focuses upon translational activities to catalyse the discovery of new medicines.
Reposted by Centre for Medicines Discovery
New in @science.org 🧬
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis
Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic depende...
www.science.org
November 6, 2025 at 7:30 PM
New in @science.org 🧬
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
Researchers from the Centre for Medicines Discovery delivered a successful public engagement event at the 2025 Green Man Festival. Their 'Medicine-Making Express' stall demystified the drug discovery journey for a national audience, engaging over 900 visitors.
www.cmd.ox.ac.uk/news/cmd-dri...
www.cmd.ox.ac.uk/news/cmd-dri...
September 19, 2025 at 9:39 AM
Researchers from the Centre for Medicines Discovery delivered a successful public engagement event at the 2025 Green Man Festival. Their 'Medicine-Making Express' stall demystified the drug discovery journey for a national audience, engaging over 900 visitors.
www.cmd.ox.ac.uk/news/cmd-dri...
www.cmd.ox.ac.uk/news/cmd-dri...
Reposted by Centre for Medicines Discovery
🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk
July 21, 2025 at 7:07 PM
🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk
Cryo-EM studies by the Bullock group @cmd.ox.ac.uk reveal how phase II drug UM171 and cancer mutations similarly reshape E3 ligase KBTBD4 to recruit neosubstrate HDAC1/2. This unexpected structural mimicry may inspire future degrader discovery. #TPD #CancerBiology rdcu.be/egdFy
April 4, 2025 at 1:22 PM
Cryo-EM studies by the Bullock group @cmd.ox.ac.uk reveal how phase II drug UM171 and cancer mutations similarly reshape E3 ligase KBTBD4 to recruit neosubstrate HDAC1/2. This unexpected structural mimicry may inspire future degrader discovery. #TPD #CancerBiology rdcu.be/egdFy
The ODDI has been featured in a Wall Street Journal article, describing the use of AI in identifying and stratifying novel targets for therapeutic intervention in Alzheimer’s disease.
www.wsj.com/articles/ai-...
www.wsj.com/articles/ai-...
AI-Powered Databases Boost the Alzheimer’s Drug Discovery Process
Researchers studying Alzheimer’s disease are using artificial intelligence-powered databases to accelerate the drug discovery process by making it easier to sift through vast amounts of biomedical dat...
www.wsj.com
April 1, 2025 at 10:49 AM
The ODDI has been featured in a Wall Street Journal article, describing the use of AI in identifying and stratifying novel targets for therapeutic intervention in Alzheimer’s disease.
www.wsj.com/articles/ai-...
www.wsj.com/articles/ai-...
Georgie Maynard and brother Charlie - LibDem MP for Witney, visited the Centre for Medicines Discovery, University of Oxford Brain Tumour Charity/CRUK funded research team led by Prof Daniel Ebner working on a five-year study to identify existing cancer drugs could shrink glioblastoma brain tumours.
March 31, 2025 at 1:49 PM
Georgie Maynard and brother Charlie - LibDem MP for Witney, visited the Centre for Medicines Discovery, University of Oxford Brain Tumour Charity/CRUK funded research team led by Prof Daniel Ebner working on a five-year study to identify existing cancer drugs could shrink glioblastoma brain tumours.