The IL1RL1 rs11685480 variant acts as a "double-edged sword": it increases expression of inflammation receptors while reducing protective "decoy" proteins (sST2). This imbalance fuels Type 2 inflammation, highlighting a vital target for precision therapy: doi.org/10.1016/j.re...

Resistance Patterns and Optimization of Empirical Therapy for Urinary Tract Infections in Patients on Trimethoprim-Sulfamethoxazole Prophylaxis Against Pneumocystis jirovecii doi.org/10.1177/1076...

Gene Polymorphisms of NLRP3 Associated With Plasma Levels of 4β‐Hydroxycholesterol, an Endogenous Marker of CYP3A Activity, in Patients With Asthma - Hirai - 2024 - Clinical Pharmacology & Therapeutics - Wiley Online Library ascpt.onlinelibrary.wiley.com/doi/10.1002/...

Development of a predictive model for neutropenia risk in Japanese breast cancer patients treated with doxorubicin and cyclophosphamide - Miyagi - British Journal of Clinical Pharmacology - Wiley Online Library bpspubs.onlinelibrary.wiley.com/doi/10.1002/...

Tezepelumab Targeting Thymic Stromal Lymphopoietin Enhances Steroid Sensitivity in Patients With Severe Asthma - Hirai - Allergy - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

Patients with severe asthma have reduced steroid sensitivity, which leads to unfavorable clinical outcomes, including exacerbations and an inability to achieve clinical remission. Conversely, inhibition of the PI3K pathway significantly improves steroid sensitivity.
doi.org/10.1016/j.ja...

Flunitrazepam increases the risk of lamotrigine‐induced cutaneous adverse reactions: Combined analysis of medical big data and clinical research - Bando - Psychiatry and Clinical Neurosciences - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

Identification of potential transcriptomic and microRNA markers to assess benralizumab effectiveness - Journal of Allergy and Clinical Immunology www.jacionline.org/article/S009...