Christoffer Clemmensen
@clemmensenc.bsky.social
Associate Professor, University of Copenhagen || Co-founder and CSO, Ousia Pharma ApS
Unfortunately not up to us to decide on full open access in this case. I hope this link will enable access: rdcu.be/evOFQ Otherwise, I am happy to share a pdf version.
Shaping the future of cardiometabolic innovation: advances and opportunities
Nature Metabolism - Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and...
rdcu.be
July 11, 2025 at 7:33 PM
Unfortunately not up to us to decide on full open access in this case. I hope this link will enable access: rdcu.be/evOFQ Otherwise, I am happy to share a pdf version.
3/3 In parallel, we developed a strategy to target NMDA receptors in appetite-regulating brain regions using peptide-drug conjugates (PDCs). With the ERC grant, we now aim to advance this work by selectively silencing neurons involved in weight regain.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
GLP-1-directed NMDA receptor antagonism for obesity treatment - Nature
Unimolecular integration of NMDA receptor antagonism with GLP-1 receptor agonism effectively reverses obesity, hyperglycaemia and dyslipidaemia in rodent models of metabolic disease.
www.nature.com
December 4, 2024 at 11:08 AM
3/3 In parallel, we developed a strategy to target NMDA receptors in appetite-regulating brain regions using peptide-drug conjugates (PDCs). With the ERC grant, we now aim to advance this work by selectively silencing neurons involved in weight regain.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
2/3 Earlier this year we reported that postsynaptic scaffolding proteins interacting with glutamatergic AMPA and NMDA receptors are potential targets for sustained weight loss
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment
Scaffolding proteins PICK1 and PSD-95 are genetically linked to obesity and therapeutic targets for sustained weight loss.
www.science.org
December 4, 2024 at 11:08 AM
2/3 Earlier this year we reported that postsynaptic scaffolding proteins interacting with glutamatergic AMPA and NMDA receptors are potential targets for sustained weight loss
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...