Clémence Fraslin
@clemencefraslin.bsky.social
Researcher in Aquaculture breeding at the Roslin Institute 🧬🐟. Quantitative genetics | Genomic selection | GWAS | Disease resistance and sustainability in aquaculture species. Dry side of the lab. (Sher/her)
From France and now in Bonnie Edinburgh
From France and now in Bonnie Edinburgh
And @salisburyfish.bsky.social wins first prize for the beat on oral communication! 🎉🎉
Well done Sarah !
#ISGAXV
Well done Sarah !
#ISGAXV
May 16, 2025 at 3:25 PM
And @salisburyfish.bsky.social wins first prize for the beat on oral communication! 🎉🎉
Well done Sarah !
#ISGAXV
Well done Sarah !
#ISGAXV
It's not a difference in cell types but how the fish use their cells (encapsulation of the parasite for coho for example) or how the parasite immunomodulatea the fish (as in Atlantic salmons)
Sarah is leaving the Roslin and starting her group in @exeter.ac.uk, she will be missed !
Sarah is leaving the Roslin and starting her group in @exeter.ac.uk, she will be missed !
May 15, 2025 at 9:09 AM
It's not a difference in cell types but how the fish use their cells (encapsulation of the parasite for coho for example) or how the parasite immunomodulatea the fish (as in Atlantic salmons)
Sarah is leaving the Roslin and starting her group in @exeter.ac.uk, she will be missed !
Sarah is leaving the Roslin and starting her group in @exeter.ac.uk, she will be missed !
As always the presentation by @salisburyfish.bsky.social was great! Using Single nuclei RNAseq data she identified genes that seems to explain why some salmonids (such as coho or pink) are resistant to sealice when others (Atlantic and chum) are susceptible
May 15, 2025 at 9:09 AM
As always the presentation by @salisburyfish.bsky.social was great! Using Single nuclei RNAseq data she identified genes that seems to explain why some salmonids (such as coho or pink) are resistant to sealice when others (Atlantic and chum) are susceptible
José's group has been instrumental in developing genomic selection and investigating generic architecture of complex disease resistance traits in salmonids in Chile with also a worldwide impact. The present resolve around high density, wgs data, will the future be gene editing? 🧬✂️
🧪🧬🖥️
🧪🧬🖥️
May 15, 2025 at 8:31 AM
José's group has been instrumental in developing genomic selection and investigating generic architecture of complex disease resistance traits in salmonids in Chile with also a worldwide impact. The present resolve around high density, wgs data, will the future be gene editing? 🧬✂️
🧪🧬🖥️
🧪🧬🖥️
There will be more, including a talk by @lucavegu.bsky.social later today on host génome and skin microbiome information for sea lice burden in A. salmon!
There are a few posters as well to look at during the breaks and poster session 👀
There are a few posters as well to look at during the breaks and poster session 👀
May 15, 2025 at 8:31 AM
There will be more, including a talk by @lucavegu.bsky.social later today on host génome and skin microbiome information for sea lice burden in A. salmon!
There are a few posters as well to look at during the breaks and poster session 👀
There are a few posters as well to look at during the breaks and poster session 👀
Day 4 at #ISGAXV starting with José M. Yáñez (Universidad de Chile) presenting the achievements and future perspectives of genetic improvement in salmonids (coho and Atlantic salmons and rainbow trout) in Chile.
From SNP array development to implementation of genomic selection 🧬🖥️🐟
From SNP array development to implementation of genomic selection 🧬🖥️🐟
May 15, 2025 at 8:31 AM
Day 4 at #ISGAXV starting with José M. Yáñez (Universidad de Chile) presenting the achievements and future perspectives of genetic improvement in salmonids (coho and Atlantic salmons and rainbow trout) in Chile.
From SNP array development to implementation of genomic selection 🧬🖥️🐟
From SNP array development to implementation of genomic selection 🧬🖥️🐟
In France, mass selection is combined with parentage assignment to maintain genetic diversity since 2012 and since 2019 genomic selection is also used to improve oyster resistance to diseases, with great success so far !
May 14, 2025 at 7:48 AM
In France, mass selection is combined with parentage assignment to maintain genetic diversity since 2012 and since 2019 genomic selection is also used to improve oyster resistance to diseases, with great success so far !
In France oysters are pretty important, and hatchery spat (baby 🦪) represent 30/40% of total spat but more than 50% of final produce because selected oysters perform better than wild one, especially when facing pathogens
May 14, 2025 at 7:48 AM
In France oysters are pretty important, and hatchery spat (baby 🦪) represent 30/40% of total spat but more than 50% of final produce because selected oysters perform better than wild one, especially when facing pathogens
Really cool presentation at #ISGAXV from Batya Dorfman on disentangling the component of disease resistance (susceptibility transmissibility and survival) of Cyprind fish species to CyHV-3. They looks at infection response in multiple challenge models with 5 carps species
May 13, 2025 at 10:07 AM
Really cool presentation at #ISGAXV from Batya Dorfman on disentangling the component of disease resistance (susceptibility transmissibility and survival) of Cyprind fish species to CyHV-3. They looks at infection response in multiple challenge models with 5 carps species
Omics can also be used to detect early pathogen outbreaks in pounds for barramundi, as shown by Varsha Balu (James Cook Uni, Australia). Using eDNA from water sampling (non invasive) she was able to detect the presence of two pathogens in pounds, that could be associated with changes in salinity.
May 13, 2025 at 8:40 AM
Omics can also be used to detect early pathogen outbreaks in pounds for barramundi, as shown by Varsha Balu (James Cook Uni, Australia). Using eDNA from water sampling (non invasive) she was able to detect the presence of two pathogens in pounds, that could be associated with changes in salinity.
Have you heard about IPNv and salmonids? Maybe you know that there is a major QTL that was identified in A. Salmon in 2008/2009... Well this time there is major QTLs identified in rainbow trout for the same disease !
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
May 12, 2025 at 4:28 PM
Have you heard about IPNv and salmonids? Maybe you know that there is a major QTL that was identified in A. Salmon in 2008/2009... Well this time there is major QTLs identified in rainbow trout for the same disease !
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
An interesting study by Brad Evans from CSIRO on seasonal growth of A. salmon in Tasmania (where the water is warmer than in Scotland). They showed differences in summer growth between families. Low genetic correlation estimates between growth measured at different time
🌨️🌧️☀️🍂
🌨️🌧️☀️🍂
May 12, 2025 at 1:52 PM
An interesting study by Brad Evans from CSIRO on seasonal growth of A. salmon in Tasmania (where the water is warmer than in Scotland). They showed differences in summer growth between families. Low genetic correlation estimates between growth measured at different time
🌨️🌧️☀️🍂
🌨️🌧️☀️🍂
Back from lunch at #ISGAXV and it's time for quantitative genetics and breeding 🧬🖥️ and we started with Cécile Massault presenting her model that captures the additive genetic host-donor interaction in pearl oyster, looking at incorporating it in breeding programme for pearl size 🦪
May 12, 2025 at 1:20 PM
Back from lunch at #ISGAXV and it's time for quantitative genetics and breeding 🧬🖥️ and we started with Cécile Massault presenting her model that captures the additive genetic host-donor interaction in pearl oyster, looking at incorporating it in breeding programme for pearl size 🦪
Why is aquaculture so interesting (in my opinion)? because of the diversity of environment and species that are farmed. Alexandre W. Silva Hilsdorf presented the beginning of farming and selecting Dusky grouper un Brasil. Using optimized LD SNP panel for accurate parentage assignment
May 12, 2025 at 11:39 AM
Why is aquaculture so interesting (in my opinion)? because of the diversity of environment and species that are farmed. Alexandre W. Silva Hilsdorf presented the beginning of farming and selecting Dusky grouper un Brasil. Using optimized LD SNP panel for accurate parentage assignment
Sara showed that using functional data alone or combined with causal variant increases the accuracy of genomic prediction of VNN resistance in sea bass. This trait is controlled by a major QTL on chr3, it would be interesting to see if we can replicate those in more polygenic traits
#EUAqua.org
#EUAqua.org
May 12, 2025 at 11:07 AM
Sara showed that using functional data alone or combined with causal variant increases the accuracy of genomic prediction of VNN resistance in sea bass. This trait is controlled by a major QTL on chr3, it would be interesting to see if we can replicate those in more polygenic traits
#EUAqua.org
#EUAqua.org
And they got an even better improvement when they used a validation population that was genetically distinct from the training population (+26%)! Very promising results as predictions accuracies are usually low when training and validation pop are distant ...
#ISGAXV
#ISGAXV
May 12, 2025 at 9:21 AM
And they got an even better improvement when they used a validation population that was genetically distinct from the training population (+26%)! Very promising results as predictions accuracies are usually low when training and validation pop are distant ...
#ISGAXV
#ISGAXV
Bing Liang from Tropical Futures Institute and James Cook University (Singapore) showed that for an optimal genomic selection for harvest traits in Malabar red snapper we need 5000 SNP and between 1200 and 1600 fish in the reference population. BayesR performed better than GBLUP for some traits
May 12, 2025 at 9:00 AM
Bing Liang from Tropical Futures Institute and James Cook University (Singapore) showed that for an optimal genomic selection for harvest traits in Malabar red snapper we need 5000 SNP and between 1200 and 1600 fish in the reference population. BayesR performed better than GBLUP for some traits
The individual tank systems are complicated and time consuming so the industry doesn't seem to be much interested (despite important potential gain). The future seems to be testing AI and machine learning with image recognition to record accurate phenotype in a more farmer friendly design!
May 12, 2025 at 8:47 AM
The individual tank systems are complicated and time consuming so the industry doesn't seem to be much interested (despite important potential gain). The future seems to be testing AI and machine learning with image recognition to record accurate phenotype in a more farmer friendly design!
Now at #ISGAXV it's the Genomic selection section, with a first talk from @marc-vdp-inrae.bsky.social presenting their results of selecting for feed efficiency in European sea bass. Starting with the individual recording of FCR and DGC in their cool "single fish per aquarium" system in Palavas
May 12, 2025 at 8:47 AM
Now at #ISGAXV it's the Genomic selection section, with a first talk from @marc-vdp-inrae.bsky.social presenting their results of selecting for feed efficiency in European sea bass. Starting with the individual recording of FCR and DGC in their cool "single fish per aquarium" system in Palavas
They published the genome sequence of 60 species, identified many sex determining markers in over 30 species which is very valuable for monosex production (as in tongue sole)
May 12, 2025 at 8:16 AM
They published the genome sequence of 60 species, identified many sex determining markers in over 30 species which is very valuable for monosex production (as in tongue sole)
And the first plenary is given by Prof Songling Chen who is giving an overview of the progress and current status of genomics and molecular breeding of marine fish in China.
His group and other researchers in China worked really hard in the last 20 years to produce valuable resources 🧬🐟
His group and other researchers in China worked really hard in the last 20 years to produce valuable resources 🧬🐟
May 12, 2025 at 8:16 AM
And the first plenary is given by Prof Songling Chen who is giving an overview of the progress and current status of genomics and molecular breeding of marine fish in China.
His group and other researchers in China worked really hard in the last 20 years to produce valuable resources 🧬🐟
His group and other researchers in China worked really hard in the last 20 years to produce valuable resources 🧬🐟
I'm in Spain to attend #ISGA next week in Cadiz. Taking the time to visit Seville y Cordoba before a week of presentations and discussions on genomics in aquaculture. Excited to be here! I'll be reporting talks on this account, so hang around if you wanna know more. For now I'm enjoying the sun! ☀️
May 10, 2025 at 6:59 AM
I'm in Spain to attend #ISGA next week in Cadiz. Taking the time to visit Seville y Cordoba before a week of presentations and discussions on genomics in aquaculture. Excited to be here! I'll be reporting talks on this account, so hang around if you wanna know more. For now I'm enjoying the sun! ☀️
Working on my first teaching material and getting inspiration from my courses back in AgroParisTech... Things moved fast in 10 years but the breeders equation is still the root of it all! 👩🏻🔬🐟 I need to find jokes that translate in English, not sure they know who Le Capitaine Haddock is...
🧬🖥️
🧬🖥️
February 24, 2025 at 2:05 PM
Working on my first teaching material and getting inspiration from my courses back in AgroParisTech... Things moved fast in 10 years but the breeders equation is still the root of it all! 👩🏻🔬🐟 I need to find jokes that translate in English, not sure they know who Le Capitaine Haddock is...
🧬🖥️
🧬🖥️
Using a holo-omic approach, integrating mutli-omics layers we found that the microbiota of affected salmon was dominated by two bacterial families Simkaniaceae and Arcobcteracea. Figure 1 of the paper shows the comparison of alpha diversity among AGD affected samples (gill score and amoebic load).
February 20, 2025 at 2:37 PM
Using a holo-omic approach, integrating mutli-omics layers we found that the microbiota of affected salmon was dominated by two bacterial families Simkaniaceae and Arcobcteracea. Figure 1 of the paper shows the comparison of alpha diversity among AGD affected samples (gill score and amoebic load).
Today is the kick-off meeting of the new exciting EuAqua.Org project! Working together towards a more sustainable organic aquaculture production 🧪🧬🐟
And we're in the beautiful Palazzo Bo of Padova university (where Galileo had lectures long ago, how cool is that?) @unipd.bsky.social
And we're in the beautiful Palazzo Bo of Padova university (where Galileo had lectures long ago, how cool is that?) @unipd.bsky.social
January 15, 2025 at 11:30 AM
Today is the kick-off meeting of the new exciting EuAqua.Org project! Working together towards a more sustainable organic aquaculture production 🧪🧬🐟
And we're in the beautiful Palazzo Bo of Padova university (where Galileo had lectures long ago, how cool is that?) @unipd.bsky.social
And we're in the beautiful Palazzo Bo of Padova university (where Galileo had lectures long ago, how cool is that?) @unipd.bsky.social