@clellandlab.bsky.social
The Clelland lab is devoted to curing neurodegenerative diseases. We are working to create therapies for patients with fatal FTD, ALS, AD, PD and other neurologic diseases
We weigh risks vs. benefits in fatal diseases—waiting for perfection shouldn’t delay life-saving therapies. Our framework guides research on CRISPR off-targets and clinical decisions.
Congrats to Ariella Angelini Stewart on her first, first-author publication!
www.nature.com/articles/s41...
Congrats to Ariella Angelini Stewart on her first, first-author publication!
www.nature.com/articles/s41...
December 2, 2025 at 7:13 PM
We weigh risks vs. benefits in fatal diseases—waiting for perfection shouldn’t delay life-saving therapies. Our framework guides research on CRISPR off-targets and clinical decisions.
Congrats to Ariella Angelini Stewart on her first, first-author publication!
www.nature.com/articles/s41...
Congrats to Ariella Angelini Stewart on her first, first-author publication!
www.nature.com/articles/s41...
Our team is developing a platform to use physiologically maintained deceased to accelerate the discovery of delivery vectors. We anticipate this will save years in creating new gene therapies. An overview and the ethical considerations is now published in Science. www.science.org/doi/10.1126/...
Discovery research in physiologically maintained deceased
Expanded research opportunities in deceased humans require ongoing ethical inquiry
www.science.org
May 2, 2025 at 11:48 PM
Our team is developing a platform to use physiologically maintained deceased to accelerate the discovery of delivery vectors. We anticipate this will save years in creating new gene therapies. An overview and the ethical considerations is now published in Science. www.science.org/doi/10.1126/...
We have created an end-to-end bioinformatics pipeline to make analyzing PacBio single molecule sequencing data easier. It handles WGS and pure target. We use it for our C9orf72 gene therapy development. Well done Tanya, the talent data scientist who lead this work! academic.oup.com/bioinformati...
nf-core/pacvar: a pipeline for analyzing long-read PacBio whole genome and repeat expansion sequencing data
AbstractMotivation. Pacific Biosciences (PacBio) single-molecule, long-read sequencing enables whole genome annotation and the characterization of 20 compl
academic.oup.com
May 1, 2025 at 4:46 PM
We have created an end-to-end bioinformatics pipeline to make analyzing PacBio single molecule sequencing data easier. It handles WGS and pure target. We use it for our C9orf72 gene therapy development. Well done Tanya, the talent data scientist who lead this work! academic.oup.com/bioinformati...
Will Elon return the billions in US grants and contracts Tesla and SpaceX receives or only block funds for hard working Americans? Is it legal to let the fox in the hen house?
February 3, 2025 at 5:21 PM
Will Elon return the billions in US grants and contracts Tesla and SpaceX receives or only block funds for hard working Americans? Is it legal to let the fox in the hen house?
We stand with our colleagues at the NIH, FDA and CDC. Promoting health and keeping our medicines safe is essential to us all and the well being of our country.
January 24, 2025 at 11:43 PM
We stand with our colleagues at the NIH, FDA and CDC. Promoting health and keeping our medicines safe is essential to us all and the well being of our country.
We believe in science.
January 23, 2025 at 7:34 PM
We believe in science.
This beautiful and moving story tells the story of Linde's fight to change the future of those with genetic FTD. We are working to create a CRISPR MAPT-FTD therapy and a better future for Linde and all with genetic neurodegenerative conditions. Thanks for sharing your story Linde!
shorturl.at/DOK1J
shorturl.at/DOK1J
A Woman With a Rare Gene Mutation Fights to Avoid Her Mother’s Fate (Gift Article)
A mutant gene is coming to steal Linde Jacobs’s mind. Can she find a way to stop it?
www.nytimes.com
December 23, 2024 at 6:43 PM
This beautiful and moving story tells the story of Linde's fight to change the future of those with genetic FTD. We are working to create a CRISPR MAPT-FTD therapy and a better future for Linde and all with genetic neurodegenerative conditions. Thanks for sharing your story Linde!
shorturl.at/DOK1J
shorturl.at/DOK1J