This study underscores the importance of genetic analyses and ecological trade-offs in understanding phage host range, with implications for basic research and applied use in biocontrol or therapy. We hope the PHRI will support #phage researchers in exploring host-range! 😀
This study underscores the importance of genetic analyses and ecological trade-offs in understanding phage host range, with implications for basic research and applied use in biocontrol or therapy. We hope the PHRI will support #phage researchers in exploring host-range! 😀
PHRI values align with modular/nested structures in phage–bacteria networks, confirming methodological consistency. We also propose and provide evidence that generalist phages are more likely to be represented in #CRISPR-Cas immune system of bacteria than specialist phages.
PHRI values align with modular/nested structures in phage–bacteria networks, confirming methodological consistency. We also propose and provide evidence that generalist phages are more likely to be represented in #CRISPR-Cas immune system of bacteria than specialist phages.
We present a new phylogenetic host-range index (PHRI) that incorporates bacterial genetic diversity to classify phages as specialists or generalists. Using epidemiological data, we link host range to local bacterial diversity and show that virulence–host range trade-offs are context-dependent
We present a new phylogenetic host-range index (PHRI) that incorporates bacterial genetic diversity to classify phages as specialists or generalists. Using epidemiological data, we link host range to local bacterial diversity and show that virulence–host range trade-offs are context-dependent
Phage host range matters for both fundamental and applied research, but how do we measure viral specialisation or generalism? We analyse diverse phages from Mauritius and Reunion infecting #Ralstonia spp. to test eco-evolutionary hypotheses and improve host-range analysis methods.
Phage host range matters for both fundamental and applied research, but how do we measure viral specialisation or generalism? We analyse diverse phages from Mauritius and Reunion infecting #Ralstonia spp. to test eco-evolutionary hypotheses and improve host-range analysis methods.