Finally, cells from patient with laminopathies exhibit very abnormal nuclear deformation in microgrooves.
This opens to the possibility of using this system as a tool to detect pathological abnormalities in nuclear mechanics...

Our latest study on nuclear deformations in microgrooves is finally out!
doi.org/10.1002/advs...
All you need to know below 👇

My new preprint is out! We highlight here different mechanisms of contact guidance in single cells and endothelial monolayers on microgrooves. Check it out!

doi.org/10.1101/2022.1…

#STED super-resolution images of microtubules 🔴 and intermediate filaments 🟢 in HUVECs. Thanks @Abberior for allowing me to try this amazing microscope!

Then we teamed up with a physicist who built a model considering the monolayer as an active fluid. By adding in the model the constraint on cell orientation provided by the grooves, we were able to predict the emergence of the cell streams!

By studying further this phenomenon, we showed that the size of the streams can be specifically controlled by the groove depth, and that the presence of cell-cell junctions is necessary for the emergence of this pattern.

To study this particular setting, we used microfabricated substrates composed of parallel arrays of micrometric grooves, which mimic the anisotropy often found in ECMs. Vascular endothelial cells cultured on these substrates align and elongate in the groove direction.

I'm so thrilled to have received a poster prize at #EMBOBuildNetworks! Microgrooves rock 🤓 It was a great meeting, big thanks to the organizers.

Very proud to see our favorite phD @ClaRamonLozano present her vessel-on-chip project at #EMBOBuildNetworks!

Another review out! I particularly enjoyed writing this views article, where we describe different and complementary mechanisms of cell response to substrate topography (DM for pdf). Enjoy!

onlinelibrary.wiley.com/doi/10.1002/cm…

Never getting tired of looking at these monolayers! 🤩

📢 We are hiring! 📢
A motivated engineer/postdoc with a background in biophysics/bioengineering and experience in microfabrication and cell culture to work on an exciting new system to study cell and nuclear mechanics.
Details hereSpread the word!

drive.google.com/file/d/1P4CwTj…

What a nice surprise to see one of my phD picture online! @SBCF1 📸🔬

I already had very interesting interactions today around my IPoster at the #Morphogenesis2020 conference.
Don't hesitate to come and check it out to know more on large scale endothelial cell movements on grooved substrates!

2 years ago (already!) I was defending my phD 🎓 @IFM_NEURO @ipggmicrofluid #postdoclife
I was working on really cool migratory behaviors of embryonic interneurons in micropillar arrays. This work was published in @Biomaterials_

sciencedirect.com/science/articl…