Claire Gizowski
@clairegizowski.bsky.social
Senior Scientist in the brain aging team at Calico studying microglia and aging 🧠
Our new preprint!
"rejuvenation-by-replacement" might not work how we expect it to…
In short, we show the local brain environment drives microglia aging, with natural killer cells acting as an unexpected but necessary upstream player driving the age-dependent, stat1-mediated interferon response.
"rejuvenation-by-replacement" might not work how we expect it to…
In short, we show the local brain environment drives microglia aging, with natural killer cells acting as an unexpected but necessary upstream player driving the age-dependent, stat1-mediated interferon response.
Heterochronic myeloid cell replacement reveals the local brain environment as key driver of microglia aging https://www.biorxiv.org/content/10.1101/2025.09.02.673859v1
September 8, 2025 at 3:45 PM
Our new preprint!
"rejuvenation-by-replacement" might not work how we expect it to…
In short, we show the local brain environment drives microglia aging, with natural killer cells acting as an unexpected but necessary upstream player driving the age-dependent, stat1-mediated interferon response.
"rejuvenation-by-replacement" might not work how we expect it to…
In short, we show the local brain environment drives microglia aging, with natural killer cells acting as an unexpected but necessary upstream player driving the age-dependent, stat1-mediated interferon response.
Great way to end a week- our very first recordings with our brand spanking new 2photon microscope @brukercorporation.bsky.social 🥳🥳🥳 🔬🐭
~Nuclear tagged macrophages in mouse cortex in vivo
~Nuclear tagged macrophages in mouse cortex in vivo
April 12, 2025 at 1:18 AM
Great way to end a week- our very first recordings with our brand spanking new 2photon microscope @brukercorporation.bsky.social 🥳🥳🥳 🔬🐭
~Nuclear tagged macrophages in mouse cortex in vivo
~Nuclear tagged macrophages in mouse cortex in vivo
Reposted by Claire Gizowski
Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
February 27, 2025 at 8:13 PM
Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
New ephys rig almost ready to rock 🤭 we’re so back
February 1, 2025 at 1:09 AM
New ephys rig almost ready to rock 🤭 we’re so back
Reposted by Claire Gizowski
We lack tools to rapidly track >1-2 changing signals in brain fluids. Peter Kalugin and an amazing team begin to address this challenge with simultaneous, real-time tracking of many (10+) neuromodulatory signals using Multiplexed Optical Recording of Sensors on a micro-Endoscope. Feedback welcome!
I’m thrilled to share our preprint presenting MORSE: a new way to simultaneously & quantitatively track patterns of neuromodulators/neuropeptides in vitro & in vivo using spatially multiplexed 3D imaging of 10+ green optical sensors on a microendoscope
biorxiv.org/content/10.1101/2025.01.26.634931v1
biorxiv.org/content/10.1101/2025.01.26.634931v1
January 27, 2025 at 2:01 PM
We lack tools to rapidly track >1-2 changing signals in brain fluids. Peter Kalugin and an amazing team begin to address this challenge with simultaneous, real-time tracking of many (10+) neuromodulatory signals using Multiplexed Optical Recording of Sensors on a micro-Endoscope. Feedback welcome!