Claire Dugast-Darzacq
@clairedugast.bsky.social
Ass. Prof. In Université Paris cité in Mol Biology and Genetics/ Unravelling transcriptional program changes during spinal cord development @ijmonod.bsky.social
Congrats Thomas Graham on this great work !
I am convinced PAPA will be widely used in the future to study protein-protein interaction dynamics in live cells 🔥🔥
I am convinced PAPA will be widely used in the future to study protein-protein interaction dynamics in live cells 🔥🔥
Online Now: Single-molecule live imaging of subunit interactions and exchange within cellular regulatory complexes Online now:
Single-molecule live imaging of subunit interactions and exchange within cellular regulatory complexes
Graham et al. show that proximity-assisted photoactivation (PAPA) can visualize interactions of endogenous proteins at single-molecule resolution in live human cells. Applying PAPA to the P-TEFb regulatory network showed that the inhibited P-TEFb:7SK complex is largely unbound to chromatin and revealed subunit exchange within 7SK complexes upon Cdk9 inhibition.
dlvr.it
July 24, 2025 at 2:12 AM
Congrats Thomas Graham on this great work !
I am convinced PAPA will be widely used in the future to study protein-protein interaction dynamics in live cells 🔥🔥
I am convinced PAPA will be widely used in the future to study protein-protein interaction dynamics in live cells 🔥🔥
Great work for Robin Rondon under the supervision of Pascale Gilardi-Hebenstreit and Vanessa Ribes
Dual PAX3/7 transcriptional activities spatially encode spinal cell fates through distinct gene networks https://www.biorxiv.org/content/10.1101/2025.03.11.642668v1
March 18, 2025 at 2:42 PM
Great work for Robin Rondon under the supervision of Pascale Gilardi-Hebenstreit and Vanessa Ribes
Reposted by Claire Dugast-Darzacq
📢 A cette occasion, un tifo sera créé au Théâtre de Fourvière à Lyon et 2500voix !
Rendez-vous ce vendredi 14 février à 21h sur le compte instagram de 2500 voix pour suivre le top départ d’un live de 27h !
➡️ https://buff.ly/40Wylo1
Rendez-vous ce vendredi 14 février à 21h sur le compte instagram de 2500 voix pour suivre le top départ d’un live de 27h !
➡️ https://buff.ly/40Wylo1
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buff.ly
February 13, 2025 at 9:03 AM
📢 A cette occasion, un tifo sera créé au Théâtre de Fourvière à Lyon et 2500voix !
Rendez-vous ce vendredi 14 février à 21h sur le compte instagram de 2500 voix pour suivre le top départ d’un live de 27h !
➡️ https://buff.ly/40Wylo1
Rendez-vous ce vendredi 14 février à 21h sur le compte instagram de 2500 voix pour suivre le top départ d’un live de 27h !
➡️ https://buff.ly/40Wylo1
Reposted by Claire Dugast-Darzacq
📣 Plus que quelques heures avant le début du live sur le compte instagram de 2500 voix ! Rendez-vous à 21h, #jejoinsmavoix !
➡️ www.instagram.com/2500voix/
➡️ www.instagram.com/2500voix/
February 14, 2025 at 7:52 AM
📣 Plus que quelques heures avant le début du live sur le compte instagram de 2500 voix ! Rendez-vous à 21h, #jejoinsmavoix !
➡️ www.instagram.com/2500voix/
➡️ www.instagram.com/2500voix/
Reposted by Claire Dugast-Darzacq
📢 Samedi 15 février aura lieu la journée mondiale de lutte contre les #cancerspediatriques. Les #cancerfighter de l’équipe de recherche Ribes/Nedelec joignent leurs voix avec 2500 voix ! Ce collectif organise des récoltes de dons intégralement reversés au réseau de recherche @react4kids.bsky.social
February 13, 2025 at 9:03 AM
📢 Samedi 15 février aura lieu la journée mondiale de lutte contre les #cancerspediatriques. Les #cancerfighter de l’équipe de recherche Ribes/Nedelec joignent leurs voix avec 2500 voix ! Ce collectif organise des récoltes de dons intégralement reversés au réseau de recherche @react4kids.bsky.social
Waouh 🤩🤩🤩
This is so so cool 🤯🤯
This is so so cool 🤯🤯
1/n Excited to share our new preprint! Using live imaging in Drosophila embryos, we show that RNA Pol II clusters switch from sites of initiation to elongation during zygotic genome activation and that they are stably associated with an active gene: www.biorxiv.org/content/10.1...
February 12, 2025 at 5:51 PM
Waouh 🤩🤩🤩
This is so so cool 🤯🤯
This is so so cool 🤯🤯
Reposted by Claire Dugast-Darzacq
Did you know CTCF has a life outside cohesin loop extrusion and 3D genome folding?
Here is a short review of these molecular activities by Aaron Corin and with @vram142.bsky.social
www.sciencedirect.com/science/arti...
Here is a short review of these molecular activities by Aaron Corin and with @vram142.bsky.social
www.sciencedirect.com/science/arti...
December 21, 2024 at 8:50 PM
Did you know CTCF has a life outside cohesin loop extrusion and 3D genome folding?
Here is a short review of these molecular activities by Aaron Corin and with @vram142.bsky.social
www.sciencedirect.com/science/arti...
Here is a short review of these molecular activities by Aaron Corin and with @vram142.bsky.social
www.sciencedirect.com/science/arti...
Reposted by Claire Dugast-Darzacq
Excited to share James Jusuf's preprint:
By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)
We quantify mESC 36k loops: are generally rare (2.3%)
www.biorxiv.org/content/10.1...
By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)
We quantify mESC 36k loops:
www.biorxiv.org/content/10.1...
January 16, 2025 at 1:35 PM
Excited to share James Jusuf's preprint:
By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)
We quantify mESC 36k loops: are generally rare (2.3%)
www.biorxiv.org/content/10.1...
By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)
We quantify mESC 36k loops:
www.biorxiv.org/content/10.1...
Reposted by Claire Dugast-Darzacq
Please check out our new paper showing that the supposed looping factor ZNF143 has no role in chromatin looping: www.cell.com/molecular-ce...
And also check out the companion paper from @andersshansen.bsky.social: www.cell.com/molecular-ce...
And also check out the companion paper from @andersshansen.bsky.social: www.cell.com/molecular-ce...
ZNF143 is a transcriptional regulator of nuclear-encoded mitochondrial genes that acts independently of looping and CTCF
ZNF143 has been implicated in gene activation and chromatin looping. Magnitov et al. show that ZNF143 has no general looping factor activity and explain why this function has been misattributed. Instead, ZNF143 regulates transcription of nuclear-encoded mitochondrial genes, ensuring energy homeostasis, proliferation, and differentiation potential of stem cells.
www.cell.com
December 20, 2024 at 4:22 PM
Please check out our new paper showing that the supposed looping factor ZNF143 has no role in chromatin looping: www.cell.com/molecular-ce...
And also check out the companion paper from @andersshansen.bsky.social: www.cell.com/molecular-ce...
And also check out the companion paper from @andersshansen.bsky.social: www.cell.com/molecular-ce...