"you should do your job and ban people spreading hate speech against a heavily politically persecuted minority group" =/= "harassment" lol. you're being asked to do your job and you're having a meltdown over it all over the site. it's honestly pretty embarrassing.
October 3, 2025 at 7:02 PM
"you should do your job and ban people spreading hate speech against a heavily politically persecuted minority group" =/= "harassment" lol. you're being asked to do your job and you're having a meltdown over it all over the site. it's honestly pretty embarrassing.
honestly insane at what an enormous fucking coward the new CEO is. hurrr durrrrr "the pendulum is swinging back in a way we didn't expect"- buddy, YOU are that pendulum swinging back! YOU'RE contributing to it! you're part of the problem! by caving, YOU are moving the needle towards the right!
June 11, 2025 at 5:39 PM
honestly insane at what an enormous fucking coward the new CEO is. hurrr durrrrr "the pendulum is swinging back in a way we didn't expect"- buddy, YOU are that pendulum swinging back! YOU'RE contributing to it! you're part of the problem! by caving, YOU are moving the needle towards the right!
it is one of the few medications out there which are common enough and capable of causing oral birth control to fail, which is why i historically have cautioned british trans men about such, because many british people DIY it for ADHD.
December 3, 2024 at 5:51 PM
it is one of the few medications out there which are common enough and capable of causing oral birth control to fail, which is why i historically have cautioned british trans men about such, because many british people DIY it for ADHD.
and yes it'll potentate oral progesterone. which you may not want, depending on how sensitive you are to it / its metabolite allopregnanolone.
December 3, 2024 at 5:49 PM
and yes it'll potentate oral progesterone. which you may not want, depending on how sensitive you are to it / its metabolite allopregnanolone.
it is a CYP2C19 inhibitor [see the two images] and an inducer of CYP1A2 / CYP3A4- so it'll reduce concentrations and length for oral estrogen, in example. but also like, dozens of medications in general.
December 3, 2024 at 5:48 PM
it is a CYP2C19 inhibitor [see the two images] and an inducer of CYP1A2 / CYP3A4- so it'll reduce concentrations and length for oral estrogen, in example. but also like, dozens of medications in general.
i would also be aware / careful of the fact that ar/modafinil interacts with quite literally a trillion things
December 3, 2024 at 5:34 PM
i would also be aware / careful of the fact that ar/modafinil interacts with quite literally a trillion things
"can you write "vote 💔" in my super ultra latte quintuple cream mega coconut vegan chocolate fake french word drink thingy. also i will be tipping 47 cents"
December 1, 2024 at 6:10 PM
"can you write "vote 💔" in my super ultra latte quintuple cream mega coconut vegan chocolate fake french word drink thingy. also i will be tipping 47 cents"
is the milk safe? there's nothing really special to it- and it depends on the pharmacological agents present in the individual, to their milk-to-plasma ratio. cocaine can pass through breast milk, in example. this will harm a baby. domperidone, though? it's fine. pubmed.ncbi.nlm.nih.gov/37352416/
The Transfer of Domperidone into Human Milk Remains Low at High Doses - PubMed
Domperidone is a dopamine-2 (D2) receptor antagonist that stimulates the release of stored prolactin in the anterior pituitary. It is prescribed off-label in Canada and Australia to promote lactation ...
pubmed.ncbi.nlm.nih.gov
December 1, 2024 at 3:25 PM
is the milk safe? there's nothing really special to it- and it depends on the pharmacological agents present in the individual, to their milk-to-plasma ratio. cocaine can pass through breast milk, in example. this will harm a baby. domperidone, though? it's fine. pubmed.ncbi.nlm.nih.gov/37352416/
in example: a common way of inducing lactation in women is through a gut motility agent called domperidone. domperidone does not cross the blood-brain barrier, but antagonizes dopamine receptors in our gut, to increase gastric emptying. when the body detects this- it nevertheless raises prolactin.
December 1, 2024 at 3:19 PM
in example: a common way of inducing lactation in women is through a gut motility agent called domperidone. domperidone does not cross the blood-brain barrier, but antagonizes dopamine receptors in our gut, to increase gastric emptying. when the body detects this- it nevertheless raises prolactin.
but anyways i don't want to spam you with a trillion replies on this thought / bsky [and twitter] are unfortunately a bad format for this kind of information sharing. hopefully i have been useful / educational.
December 1, 2024 at 3:39 AM
but anyways i don't want to spam you with a trillion replies on this thought / bsky [and twitter] are unfortunately a bad format for this kind of information sharing. hopefully i have been useful / educational.
especially important to mention w/ this in mind is that there's just really not really any case reports of adverse events involving this combo [and drug poisonings / accidents happen all of the time] that i can find, which is highly suspect, as there's always case reports for this kind of stuff.
December 1, 2024 at 3:38 AM
especially important to mention w/ this in mind is that there's just really not really any case reports of adverse events involving this combo [and drug poisonings / accidents happen all of the time] that i can find, which is highly suspect, as there's always case reports for this kind of stuff.
given the earliest example i can find of "poppers and viagra kills you" is out of SF in the 1990s, i suspect the belief is either due an incorrect assumption of their mechanisms OR some sort of protestantism finger wagging meant to scare gay men out of fucking, esp due to the article's language.
December 1, 2024 at 3:35 AM
given the earliest example i can find of "poppers and viagra kills you" is out of SF in the 1990s, i suspect the belief is either due an incorrect assumption of their mechanisms OR some sort of protestantism finger wagging meant to scare gay men out of fucking, esp due to the article's language.
b/c, clearly only a would-be rapist would possess such a dangerous drug w/ no recreational uses, even though it has plenty of recreational uses. gay men as they exist [likewise trans women such as myself] are already held under immense suspicion of being sexual deviants / would-be criminals, too.
December 1, 2024 at 3:30 AM
b/c, clearly only a would-be rapist would possess such a dangerous drug w/ no recreational uses, even though it has plenty of recreational uses. gay men as they exist [likewise trans women such as myself] are already held under immense suspicion of being sexual deviants / would-be criminals, too.
it benefits several political purposes though; it perpetuates the belief that assault is done by strangers instead of by people we know and trust, AND it adds a substance with prominent use by gay men / queer people / minorities to a schedule, heavily criminalizing it under the former belief.
December 1, 2024 at 3:28 AM
it benefits several political purposes though; it perpetuates the belief that assault is done by strangers instead of by people we know and trust, AND it adds a substance with prominent use by gay men / queer people / minorities to a schedule, heavily criminalizing it under the former belief.
good example is GHB. GHB is common to see recreationally in MSM. all you hear w/ GHB though is that it's used to "spike" drinks / is used for date rape. this is an urban legend like fentanyl in weed / hasn't been validated in literature. most assault is acquaintance-related, and via alcohol.
December 1, 2024 at 3:24 AM
good example is GHB. GHB is common to see recreationally in MSM. all you hear w/ GHB though is that it's used to "spike" drinks / is used for date rape. this is an urban legend like fentanyl in weed / hasn't been validated in literature. most assault is acquaintance-related, and via alcohol.
part of harm reduction for me is communicating accurate information, basically- it doesn't help that poppers historically have been maligned in medicine due to stuff involving gay men's sexuality and HIV/AIDS, that ends up seeming more on the side of homophobic propaganda than scientific inquiry.
December 1, 2024 at 3:19 AM
part of harm reduction for me is communicating accurate information, basically- it doesn't help that poppers historically have been maligned in medicine due to stuff involving gay men's sexuality and HIV/AIDS, that ends up seeming more on the side of homophobic propaganda than scientific inquiry.
i'd be negligent if i were to claim something were safe when it was not. but, it's not dangerous. meanwhile, things like cocaine [and its metabolite, cocaethlyene,] which people do not hold to the same PSA, is dramatically worse for one's heart than it- but people are nevertheless okay, to averages.
December 1, 2024 at 3:16 AM
i'd be negligent if i were to claim something were safe when it was not. but, it's not dangerous. meanwhile, things like cocaine [and its metabolite, cocaethlyene,] which people do not hold to the same PSA, is dramatically worse for one's heart than it- but people are nevertheless okay, to averages.
yes, the increased risk observed is a confounder specific to this population and why specifically they're being prescribed these medications- for angina, and the underlying issues which causes angina. they are not suddenly dying as is claimed in the original tweet. it's important context.
December 1, 2024 at 3:12 AM
yes, the increased risk observed is a confounder specific to this population and why specifically they're being prescribed these medications- for angina, and the underlying issues which causes angina. they are not suddenly dying as is claimed in the original tweet. it's important context.
god, we prescribe stuff like docusate sodium for constipation even though it has not been found to be different to placebo. there's a journal i like w/ Choosing Wisely called Things We Do For No Reason about the many things we do w/o evidence. shmpublications.onlinelibrary.wiley.com/action/doSea...
shmpublications.onlinelibrary.wiley.com
December 1, 2024 at 3:06 AM
god, we prescribe stuff like docusate sodium for constipation even though it has not been found to be different to placebo. there's a journal i like w/ Choosing Wisely called Things We Do For No Reason about the many things we do w/o evidence. shmpublications.onlinelibrary.wiley.com/action/doSea...