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cirtn.bsky.social
CIRTN-R2FIC
@cirtn.bsky.social
We are the Canadian Islet Research and Training Network / Réseau de researche et formation sur les îlots du Canada.
Find out more at Islets.ca
Note: Account is primarily run by the volunteer trainee committee.
🧵(4/4) end of Oct 2025.
3) From Dr. Marc Prentki
"ABHD6 suppression attenuates pro-inflammatory responses in mice and promotes anti-inflammatory polarization of macrophages during endotoxin stress" PMID: 41061850
www.sciencedirect.com/science/arti...
ABHD6 suppression attenuates pro-inflammatory responses in mice and promotes anti-inflammatory polarization of macrophages during endotoxin stress
α/β-hydrolase domain-containing-6 (ABHD6) hydrolyzes various lipids, including monoacylglycerols (MAGs). Pharmacological inhibition of ABHD6 with WWL7…
www.sciencedirect.com
November 3, 2025 at 7:42 PM
🧵(3/4) end of Oct 2025.
2) From Dr. Megan Levings
"Lactic acid improves Treg manufacturing and in vivo function" PMID: 41146876
www.cell.com/molecular-th...
Lactic acid improves Treg manufacturing and in vivo function
Addition of lactic acid to a human Treg manufacturing protocol enhanced viability, expansion, purity, and suppressive function. Lactic acid also reduced tonic CAR signaling, preventing expression of e...
www.cell.com
November 3, 2025 at 7:42 PM
🧵(2/4) end of Oct 2025.
1) From Dr. Rennian Wang.
"The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in MIN6 cells" PMID: 41165773
link.springer.com/article/10.1...
The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in MIN6 cells - Cell and Tissue Research
There is intense public interest in the potential of antioxidant supplements as a preventative treatment for conditions associated with increased oxidative stress, such as type 2 diabetes mellitus. Ho...
link.springer.com
November 3, 2025 at 7:42 PM
🧵(4/4) For the first half of October 2025
Lab of Dr. Guy Rutter
"I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression"
PMID: 41003698
link.springer.com/article/10.1...
I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression - Diabetologia
Aims/hypothesis The bromodomain and extra-terminal (BET) protein family acts as ‘epigenetic readers’ to identify the acetylation marks on histones that convert the acetylated lysine residues into obse...
link.springer.com
October 16, 2025 at 1:57 AM
🧵(3/4) For the first half of October 2025
Labs of Drs. Francis Lynn, James Shapiro and Tatsuya Kin
"Truncated CD19 as a selection marker for the isolation of stem cell derived β-cells"
PMID: 41048051
journals.biologists.com/dmm/article/...
October 16, 2025 at 1:57 AM
🧵(2/4) For the first half of October 2025
Lab of Dr. Bruce Verchere with Dr. Yi-Chun Chen
"Assessment of protein synthesis rate enables metabolic profiling of resident-immune cells of the islets of Langerhans"
PMID: 41063994
www.frontiersin.org/journals/imm...
Frontiers | Assessment of protein synthesis rate enables metabolic profiling of resident-immune cells of the islets of Langerhans
Pancreatic islet-resident immune cells, such as lymphocytes and macrophages, support islet homeostasis, beta cell development, and tissue repair. In patholog...
www.frontiersin.org
October 16, 2025 at 1:57 AM
🧵(7/7) Here are the publications from the 2nd half of Sept.2025
From Dr. Bruce Verchere
“α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion” PMID: 40971442
www.science.org/doi/10.1126/...
α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion
α cells can generate and secrete both glucagon and GLP-1 with distinct processing enzymes to control metabolism.
www.science.org
October 1, 2025 at 8:50 PM
🧵(6/7) Here are the publications from the 2nd half of Sept.2025
From Dr. James Shapiro
“The bidirectional link between diabetes and pancreatic cancer: A diagnostic aid, risk factor, and potential target for future therapy” PMID: 41005205
www.sciencedirect.com/science/arti...
The bidirectional link between diabetes and pancreatic cancer: A diagnostic aid, risk factor, and potential target for future therapy
Historically, patients with pancreatic cancer presented with hyperglycemia and glycemic intolerance, leading to a hypothesis that diabetes may be asso…
www.sciencedirect.com
October 1, 2025 at 8:50 PM
🧵(5/7) Here are the publications from the 2nd half of Sept.2025
From Dr. Patrick MacDonald
"Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes” PMID: 41026524
www.jci.org/articles/vie...
JCI - Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes
www.jci.org
October 1, 2025 at 8:50 PM
🧵(4/7) Here are the publications from the 2nd half of Sept.2025
From Dr. Peter Light
"“Furin may contribute to proglucagon processing and Glucagon-Like Peptide-1 production in human alpha cells.”
PMID: 41022304
www.sciencedirect.com/science/arti...
Furin may contribute to proglucagon processing and Glucagon-Like Peptide-1 production in human alpha cells.
Glucagon-like peptide-1 (GLP-1) supports beta cell health and function by potentiating glucose-dependent insulin production and secretion. While GLP-1…
www.sciencedirect.com
October 1, 2025 at 8:50 PM
🧵(3/7) Here are the publications from the 2nd half of Sept.2025
From Dr. Mourad Ferdaoussi
“Ketone Therapy Prevents Semaglutide-induced Loss of Cardiac Mass” PMID: 41026893
academic.oup.com/eurjpc/advan...
Ketone Therapy Prevents Semaglutide-induced Loss of Cardiac Mass
Mya A Schmidt, MSc, Yasser Abuetabh, PhD, Masaaki Naganuma, MD, PhD, Ramana Vaka, PhD, Matthieu C P Zolondek, BSc, Jody L Levasseur, BSc, Daniela Y Morales
academic.oup.com
October 1, 2025 at 8:50 PM
🧵(2/7) Here are the publications from the 2nd half of Sept.2025
From Dr. Jenny Bruin:
"The Association Between Pregnancy Complications and Long-term Maternal Cardiometabolic Health in the MIREC Cohort Study" PMID: 39844354
academic.oup.com/jcem/article...
The Association Between Pregnancy Complications and Long-term Maternal Cardiometabolic Health in the MIREC Cohort Study
AbstractContext. During pregnancy, women who experience certain pregnancy complications show elevations in biomarkers of inflammation and insulin resistanc
academic.oup.com
October 1, 2025 at 8:50 PM
September 15, 2025 at 8:57 PM
🧵(2/3) Cont' beginning of Sept 2025:
2) “Glycerol and glycerol-3-phosphate: multifaceted metabolites in metabolism, cancer and other diseases” PMID: 40927981
3) “Osteocalcin has many tricks to get γ-carboxylated” PMID: 40913186
Links in last thread
September 15, 2025 at 8:57 PM
Please note: The account is run by trainee Ekaterina Filatov from Dr. Francis Lynn’s lab.
Please feel free to message over BlueSky or email through CIRTN.
September 12, 2025 at 9:12 PM
Our post highlighting studies from the first half of September from the CIRTN labs will come out next week, so stay tuned!
September 12, 2025 at 9:12 PM
The posts you will see from this account will spotlight publications from our labs, including titles of the published works and PMIDs, but without bias and interpretation. We encourage viewers of our page to share posts and to keep discourse to re-posts.
September 12, 2025 at 9:12 PM