Chris Toseland
@christoseland.bsky.social
Prof. Cancer Biophysics at University of Sheffield.
Investigating Nuclear Myosin, Nuclear Organisation and Mechanobiology in Cancer with single molecule Biophysics
Web: Toseland-lab.com
Investigating Nuclear Myosin, Nuclear Organisation and Mechanobiology in Cancer with single molecule Biophysics
Web: Toseland-lab.com
Perturbation of Myosin VI enhances the effect of endocrine therapies. Moreover, Myosin VI is still required for hormone-independent ER mutants thereby providing a potential avenue to overcome therapy resistance.
November 14, 2025 at 9:33 AM
Perturbation of Myosin VI enhances the effect of endocrine therapies. Moreover, Myosin VI is still required for hormone-independent ER mutants thereby providing a potential avenue to overcome therapy resistance.
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
November 14, 2025 at 9:33 AM
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 5, 2025 at 9:18 AM
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
It’s Halloween so time to make the cells scream!
October 31, 2025 at 8:23 AM
It’s Halloween so time to make the cells scream!
Yesterday we had the School of Medicine and Population Health PGR symposium - a fantastic range of talks and posters from our students!
We had excellent career sessions from Faith Nutter Howard David King and Amy Turner
Thanks to our ECRs who gave a useful and honest take on finishing a PhD.
We had excellent career sessions from Faith Nutter Howard David King and Amy Turner
Thanks to our ECRs who gave a useful and honest take on finishing a PhD.
July 9, 2025 at 6:54 AM
Yesterday we had the School of Medicine and Population Health PGR symposium - a fantastic range of talks and posters from our students!
We had excellent career sessions from Faith Nutter Howard David King and Amy Turner
Thanks to our ECRs who gave a useful and honest take on finishing a PhD.
We had excellent career sessions from Faith Nutter Howard David King and Amy Turner
Thanks to our ECRs who gave a useful and honest take on finishing a PhD.
Doubling up on the measurements and toys today - so great and useful to have this kit next door to each other!
July 3, 2025 at 4:05 PM
Doubling up on the measurements and toys today - so great and useful to have this kit next door to each other!
Back in Harwell again for a late night reagent drop!
May 18, 2025 at 8:52 PM
Back in Harwell again for a late night reagent drop!
Quick visit back to Sheffield for more samples complete!
May 15, 2025 at 9:25 PM
Quick visit back to Sheffield for more samples complete!
Back in the lab’s second home for two weeks!
May 13, 2025 at 7:50 PM
Back in the lab’s second home for two weeks!
Thank you for all the donations! It makes a massive difference to the charity and families!
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www.justgiving.com/team/thalia
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www.justgiving.com/team/thalia
April 26, 2025 at 9:07 AM
Thank you for all the donations! It makes a massive difference to the charity and families!
.
www.justgiving.com/team/thalia
.
www.justgiving.com/team/thalia
Early start media day! So proud to talk about Thalia…Morning radio then BBC Look North later
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#cancer #braintumours #childhoodcancer
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#cancer #braintumours #childhoodcancer
April 15, 2025 at 5:45 AM
Early start media day! So proud to talk about Thalia…Morning radio then BBC Look North later
.
#cancer #braintumours #childhoodcancer
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#cancer #braintumours #childhoodcancer
Day in the life of an academic - smFRET onto Lattice light sheet then delivering an afternoon workshop
March 27, 2025 at 2:23 PM
Day in the life of an academic - smFRET onto Lattice light sheet then delivering an afternoon workshop
Some great talks coming up this morning!
March 26, 2025 at 11:11 AM
Some great talks coming up this morning!
We are walking the Ullswater Way with OSCAR's Paediatric Brain Tumour Charity in May.
Learn more and donate here: www.justgiving.com/team/thalia
#braintumours #childhoodcancer #cancer
Learn more and donate here: www.justgiving.com/team/thalia
#braintumours #childhoodcancer #cancer
March 19, 2025 at 7:43 AM
We are walking the Ullswater Way with OSCAR's Paediatric Brain Tumour Charity in May.
Learn more and donate here: www.justgiving.com/team/thalia
#braintumours #childhoodcancer #cancer
Learn more and donate here: www.justgiving.com/team/thalia
#braintumours #childhoodcancer #cancer
Like plucking a tiny guitar string!
March 18, 2025 at 3:47 PM
Like plucking a tiny guitar string!
How can we hope for things to improve when I send @braintumourrsch.bsky.social letter to our MP @JakeBenRichards then get a reply about Pancreatic cancer! Not good enough!
March 13, 2025 at 8:19 PM
How can we hope for things to improve when I send @braintumourrsch.bsky.social letter to our MP @JakeBenRichards then get a reply about Pancreatic cancer! Not good enough!
We are so proud of how Thalia has handled the past two years and continues to approach every day! Brain tumours are devastating and we desperately need more treatments to provide options for families!
March 2, 2025 at 5:21 PM
We are so proud of how Thalia has handled the past two years and continues to approach every day! Brain tumours are devastating and we desperately need more treatments to provide options for families!
Fantastic few days on a grant panel in Poland - fantastic level of science and nice to explore Krakow!
February 22, 2025 at 10:14 AM
Fantastic few days on a grant panel in Poland - fantastic level of science and nice to explore Krakow!
Merry Christmas!
December 24, 2024 at 6:17 PM
Merry Christmas!
First time back at the Christmas markets in 10 years!
December 6, 2024 at 9:59 PM
First time back at the Christmas markets in 10 years!
Playing with condensates on the AFM
December 4, 2024 at 5:47 PM
Playing with condensates on the AFM
Fantastic end of the week - Ana gave a fantastic Dept talk - then we got to play Noah’s cells on the AFM
November 29, 2024 at 6:19 PM
Fantastic end of the week - Ana gave a fantastic Dept talk - then we got to play Noah’s cells on the AFM
Another PhD opportunity- This time with Ivana Barbaric in Biosciences….come join us to play on this bit of kit!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 22, 2024 at 6:58 PM
Another PhD opportunity- This time with Ivana Barbaric in Biosciences….come join us to play on this bit of kit!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...