Chris Tape
@christophertape.bsky.social
Group Leader, UCL Cancer Institute.
Studying how different cell-types collaborate to drive cancer | http://tape-lab.com
Studying how different cell-types collaborate to drive cancer | http://tape-lab.com
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
October 31, 2025 at 8:45 AM
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
Important new paper from @batllelab.bsky.social showing how the KRAS-G12D inhibitor (RMC-9945) triggers rapid stem cell switching in CRC.
This switch happens in just a few hours — similar to what we see with tumour cell responses to CAFs.
aacrjournals.org/cancerdiscov...
This switch happens in just a few hours — similar to what we see with tumour cell responses to CAFs.
aacrjournals.org/cancerdiscov...
October 25, 2025 at 1:16 PM
Important new paper from @batllelab.bsky.social showing how the KRAS-G12D inhibitor (RMC-9945) triggers rapid stem cell switching in CRC.
This switch happens in just a few hours — similar to what we see with tumour cell responses to CAFs.
aacrjournals.org/cancerdiscov...
This switch happens in just a few hours — similar to what we see with tumour cell responses to CAFs.
aacrjournals.org/cancerdiscov...
In summary, these results suggest that γδ T cell multimodal cytotoxicity can buffer γδ T cell signalling from patient-specific cancer cell immunomodulation, allowing γδ T cells from a range of donors to kill chemorefractory cancer cells. (12/13)
October 14, 2025 at 5:07 PM
In summary, these results suggest that γδ T cell multimodal cytotoxicity can buffer γδ T cell signalling from patient-specific cancer cell immunomodulation, allowing γδ T cells from a range of donors to kill chemorefractory cancer cells. (12/13)
CRC PDOs comprise an admixture of chemosensitive proliferative colonic stem cells (proCSCs) and chemorefractory revival colonic stem cells (revCSCs). Crucially, stIL-15-γδ T cells can kill PDOs irrespective of stem cell admixture — including chemorefractory PDOs. (10/13)
October 14, 2025 at 5:07 PM
CRC PDOs comprise an admixture of chemosensitive proliferative colonic stem cells (proCSCs) and chemorefractory revival colonic stem cells (revCSCs). Crucially, stIL-15-γδ T cells can kill PDOs irrespective of stem cell admixture — including chemorefractory PDOs. (10/13)
To confirm that the anti-B7-H3 antibody was only inducing ADCC and not invoking the putative immune checkpoint properties of B7-H3, we also demonstrated that only a complete IgG — and not an Fc-null IgG — could trigger multimodal killing. (9/13)
October 14, 2025 at 5:07 PM
To confirm that the anti-B7-H3 antibody was only inducing ADCC and not invoking the putative immune checkpoint properties of B7-H3, we also demonstrated that only a complete IgG — and not an Fc-null IgG — could trigger multimodal killing. (9/13)
Importantly, PDO immunomodulation of γδ T cells correlates with reduce AIC killing (i.e. the more PDOs change γδ T cell signalling, the worse γδ T cells kill). However, when γδ T cells also use AIC + ADCC, PTM signalling was restored and γδ T cells could kill all PDOs. (8/13)
October 14, 2025 at 5:07 PM
Importantly, PDO immunomodulation of γδ T cells correlates with reduce AIC killing (i.e. the more PDOs change γδ T cell signalling, the worse γδ T cells kill). However, when γδ T cells also use AIC + ADCC, PTM signalling was restored and γδ T cells could kill all PDOs. (8/13)
We found that γδ T cells can kill both MSS and MSI CRC PDOs. However, when γδ T cells only use AIC, γδ T cell signalling converges on the target PDO, irrespective of T-cell donor. This suggests that γδ T cells are immunomodulated by PDOs and ITH is dominant over IDH. (7/13)
October 14, 2025 at 5:07 PM
We found that γδ T cells can kill both MSS and MSI CRC PDOs. However, when γδ T cells only use AIC, γδ T cell signalling converges on the target PDO, irrespective of T-cell donor. This suggests that γδ T cells are immunomodulated by PDOs and ITH is dominant over IDH. (7/13)
Next, we found that stIL15-engineered γδ T cells can rapidly kill MSI colorectal cancer (CRC) patient-derived organoids (PDOs) in 3D via AIC. Killing could be further increased by inducing ADCC via a novel anti-B7-H3 antibody — demonstrating multimodal cytotoxicity. (5/13)
October 14, 2025 at 5:07 PM
Next, we found that stIL15-engineered γδ T cells can rapidly kill MSI colorectal cancer (CRC) patient-derived organoids (PDOs) in 3D via AIC. Killing could be further increased by inducing ADCC via a novel anti-B7-H3 antibody — demonstrating multimodal cytotoxicity. (5/13)
First, we found that expressing stabilised IL-15Rα–IL-15 (stIL15) enables γδ T cells to survive in 3D cultures without serum or cytokine support. This is important because many T-cell killing assays are performed in 2D with serum, but tumours are 3D and nutrient-deprived. (4/13)
October 14, 2025 at 5:07 PM
First, we found that expressing stabilised IL-15Rα–IL-15 (stIL15) enables γδ T cells to survive in 3D cultures without serum or cytokine support. This is important because many T-cell killing assays are performed in 2D with serum, but tumours are 3D and nutrient-deprived. (4/13)
γδ T cells can kill cancer cells via antibody-independent cytotoxicity (AIC) and antibody-dependent cellular cytotoxicity (ADCC), but how this killing varies across T cell donors (inter-donor heterogeneity, IDH) and patients (inter-tumour heterogeneity, ITH) is unclear. (2/13)
October 14, 2025 at 5:07 PM
γδ T cells can kill cancer cells via antibody-independent cytotoxicity (AIC) and antibody-dependent cellular cytotoxicity (ADCC), but how this killing varies across T cell donors (inter-donor heterogeneity, IDH) and patients (inter-tumour heterogeneity, ITH) is unclear. (2/13)
Excited to share our new paper: ‘Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation’ led by Callum Nattress in collab. with Jonathan Fisher lab (1/13)
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
October 14, 2025 at 5:07 PM
Excited to share our new paper: ‘Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation’ led by Callum Nattress in collab. with Jonathan Fisher lab (1/13)
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
Applications are now open for the @cruk-cityoflondon.bsky.social Black Leaders in Cancer PhD Programme.
If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch!
www.colcc.ac.uk/2026-blic-ph...
If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch!
www.colcc.ac.uk/2026-blic-ph...
October 2, 2025 at 3:01 PM
Applications are now open for the @cruk-cityoflondon.bsky.social Black Leaders in Cancer PhD Programme.
If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch!
www.colcc.ac.uk/2026-blic-ph...
If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch!
www.colcc.ac.uk/2026-blic-ph...
Excited to be in Essen for @helloeacr.bsky.social Goodbye Flat Biology 🧫
September 23, 2025 at 10:57 AM
Excited to be in Essen for @helloeacr.bsky.social Goodbye Flat Biology 🧫
A warm welcome to the newest member of the team: Lab-bubu
September 3, 2025 at 12:26 PM
A warm welcome to the newest member of the team: Lab-bubu
We are recruiting! Our lab is looking for a new mass cytometry technician to help study colorectal cancer organoid perturbation experiments at scale.
Please feel free to contact me with any questions!
Full job description and application details here: www.ucl.ac.uk/work-at-ucl/...
Please feel free to contact me with any questions!
Full job description and application details here: www.ucl.ac.uk/work-at-ucl/...
August 7, 2025 at 7:24 AM
We are recruiting! Our lab is looking for a new mass cytometry technician to help study colorectal cancer organoid perturbation experiments at scale.
Please feel free to contact me with any questions!
Full job description and application details here: www.ucl.ac.uk/work-at-ucl/...
Please feel free to contact me with any questions!
Full job description and application details here: www.ucl.ac.uk/work-at-ucl/...
Incredibly impressed by the student/postdoc run @bacell3d.bsky.social conference. Great talks, a vibrant community, and so well organised 👏
June 26, 2025 at 3:47 AM
Incredibly impressed by the student/postdoc run @bacell3d.bsky.social conference. Great talks, a vibrant community, and so well organised 👏
Congrats to Rhianna O’Sullivan for winning a poster prize at the UCL Cancer Institute conference! 👏
June 23, 2025 at 7:04 PM
Congrats to Rhianna O’Sullivan for winning a poster prize at the UCL Cancer Institute conference! 👏
Excited to be in Basel for BaCell3D @bacell3d.bsky.social
June 23, 2025 at 11:42 AM
Excited to be in Basel for BaCell3D @bacell3d.bsky.social
Excited to visit @nkinl.bsky.social today!
June 12, 2025 at 7:27 AM
Excited to visit @nkinl.bsky.social today!
We are recruiting! We're searching for a postdoctoral research fellow to study patient-specific regulators of plasticity in primary and metastatic CRC. Please reach out if you have any questions! www.ucl.ac.uk/work-at-ucl/...
May 23, 2025 at 3:32 PM
We are recruiting! We're searching for a postdoctoral research fellow to study patient-specific regulators of plasticity in primary and metastatic CRC. Please reach out if you have any questions! www.ucl.ac.uk/work-at-ucl/...
Excited to arrive in Whistler for the @keystonesymposia.bsky.social on Organoids and Single Cells 🇨🇦 🐻
May 11, 2025 at 11:12 PM
Excited to arrive in Whistler for the @keystonesymposia.bsky.social on Organoids and Single Cells 🇨🇦 🐻
Congrats to Corinne Molyneux for winning a poster prize at the UCL Cancer Domain Symposium! 👏
May 1, 2025 at 4:28 PM
Congrats to Corinne Molyneux for winning a poster prize at the UCL Cancer Domain Symposium! 👏
Upgrade to our single-cell organoid dissociation factory 💥
April 4, 2025 at 10:58 AM
Upgrade to our single-cell organoid dissociation factory 💥
We are recruiting for a new Research Technician to join the @cruk-cityoflondon.bsky.social Organoid Platform!
Full details at: www.ucl.ac.uk/work-at-ucl/...
Full details at: www.ucl.ac.uk/work-at-ucl/...
March 31, 2025 at 7:52 AM
We are recruiting for a new Research Technician to join the @cruk-cityoflondon.bsky.social Organoid Platform!
Full details at: www.ucl.ac.uk/work-at-ucl/...
Full details at: www.ucl.ac.uk/work-at-ucl/...