As a consequence, copper is a single metal nutrient that now centrally controls both genome integrity and metabolic respiration in the cell. This allows cells with high needs for Cu, like locus coeruleus neurons in the brain, to boost activity while avoiding Cu toxicity from oxidative stress.

Acquisition of a histidine pair in RAD23B from amphibians to reptiles enables it to bind copper, making its ancient DNA repair function Cu-dependent and evolving a new function as a metalloadaptor that regulates all major Cu metallochaperone pathways, including those boosting respiration

Thanks Mircea!

Thanks Boris!

Thanks Gilles!

Cool to see this lipid-redox crosstalk!

Cells with low levels of bioavailable Cu or Fe are susceptible to selective killing by chelation therapy to reduce Cu or Fe-dependent cell growth and proliferation, revealing a disease-relevant metal landscape that can be leveraged for new therapeutics chemistry.princeton.edu/news/chang-l... 2/end

Thanks Matt!

Yes, Michelle and I moved this fall!

Thanks! We need to do a poll on whether it is “metalloallostery” or “metallostery” 🤭

Thanks for hosting a fantastic day at NCI, was a lot of fun!

Welcome!

Hah! Where it all began…

Thanks, happy to be here!