@chrisoh1.bsky.social
#OTILT In a retrospective, single center study, empiric vancomycin and clindamycin or linezolid were used to study the duration of therapy for necrotizing soft tissue infections. The study found empiric linezolid for NSTI was associated with one less day of therapy compared to vanco and clindamycin.
September 5, 2025 at 12:20 AM
#OTILT In a retrospective, single center study, empiric vancomycin and clindamycin or linezolid were used to study the duration of therapy for necrotizing soft tissue infections. The study found empiric linezolid for NSTI was associated with one less day of therapy compared to vanco and clindamycin.
#OTILT The swarming motility of Proteus mirabilis and the secretion of a polysaccharide allows the bacteria to attach and move along the surfaces of medical equipment. www.ncbi.nlm.nih.gov/books/NBK442... @bwdionne.bsky.social @cheungalison.bsky.social @jeffpears0n.bsky.social
September 3, 2025 at 9:28 PM
#OTILT The swarming motility of Proteus mirabilis and the secretion of a polysaccharide allows the bacteria to attach and move along the surfaces of medical equipment. www.ncbi.nlm.nih.gov/books/NBK442... @bwdionne.bsky.social @cheungalison.bsky.social @jeffpears0n.bsky.social
#OTILT PICC lines are generally not recommended in patients with ESRD since preservation of peripheral veins are important for the creation of fistulas that are needed for dialysis access.
www.ajkd.org/article/S027...
www.ajkd.org/article/S027...
August 29, 2025 at 8:26 PM
#OTILT PICC lines are generally not recommended in patients with ESRD since preservation of peripheral veins are important for the creation of fistulas that are needed for dialysis access.
www.ajkd.org/article/S027...
www.ajkd.org/article/S027...
In patients with HIV receiving antiretroviral therapy, CD4 counts increase steeply during the first three months of therapy and continues to rise up to 10 years of therapy. pubmed.ncbi.nlm.nih.gov/27650226/@je... @bwdionne.bsky.social @cheungalison.bsky.social
August 29, 2025 at 2:42 AM
In patients with HIV receiving antiretroviral therapy, CD4 counts increase steeply during the first three months of therapy and continues to rise up to 10 years of therapy. pubmed.ncbi.nlm.nih.gov/27650226/@je... @bwdionne.bsky.social @cheungalison.bsky.social
#OTILT Cefiderocol, also known as Fetroja, uses a trojan horse method by binding to bacterial iron transported and then binding to PBP-3 allowing for the drug to rapidly accumulate in the periplasmic space.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
August 28, 2025 at 1:50 AM
#OTILT Cefiderocol, also known as Fetroja, uses a trojan horse method by binding to bacterial iron transported and then binding to PBP-3 allowing for the drug to rapidly accumulate in the periplasmic space.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
#OTILT Total parenteral nutrition is not recommended for patients with sepsis as it worsens the outcomes of sepsis by increasing resistant pathogens.
pmc.ncbi.nlm.nih.gov/articles/PMC.... @jeffpears0n.bsky.social @bwdionne.bsky.social @cheungalison.bsky.social
pmc.ncbi.nlm.nih.gov/articles/PMC.... @jeffpears0n.bsky.social @bwdionne.bsky.social @cheungalison.bsky.social
August 26, 2025 at 9:04 PM
#OTILT Total parenteral nutrition is not recommended for patients with sepsis as it worsens the outcomes of sepsis by increasing resistant pathogens.
pmc.ncbi.nlm.nih.gov/articles/PMC.... @jeffpears0n.bsky.social @bwdionne.bsky.social @cheungalison.bsky.social
pmc.ncbi.nlm.nih.gov/articles/PMC.... @jeffpears0n.bsky.social @bwdionne.bsky.social @cheungalison.bsky.social
#OTILT Antimicrobial lock therapy is used to treat CRBSIs especially in cases where the removal of the catheter is not possible such as patients receiving intravenous chemotherapy, parenteral nutrition, or hemodialysis.
www.mdpi.com/2076-2607/13...
@bwdionne.bsky.social @cheungalison.bsky.social
www.mdpi.com/2076-2607/13...
@bwdionne.bsky.social @cheungalison.bsky.social
August 25, 2025 at 8:59 PM
#OTILT Antimicrobial lock therapy is used to treat CRBSIs especially in cases where the removal of the catheter is not possible such as patients receiving intravenous chemotherapy, parenteral nutrition, or hemodialysis.
www.mdpi.com/2076-2607/13...
@bwdionne.bsky.social @cheungalison.bsky.social
www.mdpi.com/2076-2607/13...
@bwdionne.bsky.social @cheungalison.bsky.social
#OTILT Blood culture negative endocarditis is when a patient has endocarditis but has negative blood cultures. The prevalence of blood culture negative endocarditis from prior antibiotic use is between 35% to 74%.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
August 22, 2025 at 7:22 PM
#OTILT Blood culture negative endocarditis is when a patient has endocarditis but has negative blood cultures. The prevalence of blood culture negative endocarditis from prior antibiotic use is between 35% to 74%.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
#OTILT Daptomycin induced eosinophilic pneumonia is a rare adverse effect that could result in respiratory failure and mortality. Symptoms present with fever, dyspnea, and lung infiltrates on imaging. pmc.ncbi.nlm.nih.gov/articles/PMC...
August 22, 2025 at 12:06 AM
#OTILT Daptomycin induced eosinophilic pneumonia is a rare adverse effect that could result in respiratory failure and mortality. Symptoms present with fever, dyspnea, and lung infiltrates on imaging. pmc.ncbi.nlm.nih.gov/articles/PMC...
#OTILT Ivermectin is commonly used for the treatment of Strongyloides stercoralis infection. In a multi center phase 3 study, multiple doses of ivermectin was not shown to be more efficacious than a single dose of ivermectin for the treatment of strongyloidiasis.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
August 20, 2025 at 7:23 PM
#OTILT Ivermectin is commonly used for the treatment of Strongyloides stercoralis infection. In a multi center phase 3 study, multiple doses of ivermectin was not shown to be more efficacious than a single dose of ivermectin for the treatment of strongyloidiasis.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
#OTILT Ceftriaxone should not be given with calcium solutions in patients due to an increased risk of precipitation. IV ceftriaxone and IV calcium should not be administered within 2 days of one another. pmc.ncbi.nlm.nih.gov/articles/PMC...
Notice to Hospitals Regarding Ceftriaxone–Calcium Incompatibility: What’s a Clinician to Do?
pmc.ncbi.nlm.nih.gov
August 20, 2025 at 2:35 AM
#OTILT Ceftriaxone should not be given with calcium solutions in patients due to an increased risk of precipitation. IV ceftriaxone and IV calcium should not be administered within 2 days of one another. pmc.ncbi.nlm.nih.gov/articles/PMC...
#OTILT First line treatment for clostridial sepsis caused by C. perfringens is penicillin G and clindamycin, tetracycline, or metronidazole with surgical debridement of necrotic tissue. @jeffpears0n.bsky.social @bwdionne.bsky.social @cheungalison.bsky.social
www.ncbi.nlm.nih.gov/books/NBK559...
www.ncbi.nlm.nih.gov/books/NBK559...
August 19, 2025 at 1:58 AM
#OTILT First line treatment for clostridial sepsis caused by C. perfringens is penicillin G and clindamycin, tetracycline, or metronidazole with surgical debridement of necrotic tissue. @jeffpears0n.bsky.social @bwdionne.bsky.social @cheungalison.bsky.social
www.ncbi.nlm.nih.gov/books/NBK559...
www.ncbi.nlm.nih.gov/books/NBK559...
#OTILT Immortal time bias happens when a time dependent exposure is not included in an analysis of a survival outcome. It can be avoided by using a hazards-based regression model where treatment is a time-dependent variable.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
August 15, 2025 at 10:13 PM
#OTILT Immortal time bias happens when a time dependent exposure is not included in an analysis of a survival outcome. It can be avoided by using a hazards-based regression model where treatment is a time-dependent variable.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
#OTILT For oral administration, amoxicillin is typically preferred over ampicillin due to its higher bioavailability (85% vs. 50%). www.uspharmacist.com/article/the-...
pubmed.ncbi.nlm.nih.gov/4680813/#:~:....
@jeffpears0n.bsky.social @cheungalison.bsky.social @bwdionne.bsky.social
pubmed.ncbi.nlm.nih.gov/4680813/#:~:....
@jeffpears0n.bsky.social @cheungalison.bsky.social @bwdionne.bsky.social
August 13, 2025 at 5:36 PM
#OTILT For oral administration, amoxicillin is typically preferred over ampicillin due to its higher bioavailability (85% vs. 50%). www.uspharmacist.com/article/the-...
pubmed.ncbi.nlm.nih.gov/4680813/#:~:....
@jeffpears0n.bsky.social @cheungalison.bsky.social @bwdionne.bsky.social
pubmed.ncbi.nlm.nih.gov/4680813/#:~:....
@jeffpears0n.bsky.social @cheungalison.bsky.social @bwdionne.bsky.social
#OTILT Antibiotic treatment of Enterococcus spp. is more clinically important in immunocompromised patients that have intra-abdominal infections. pmc.ncbi.nlm.nih.gov/articles/PMC...
@bwdionne.bsky.social @cheungalison.bsky.social @jeffpears0n.bsky.social
@bwdionne.bsky.social @cheungalison.bsky.social @jeffpears0n.bsky.social
August 12, 2025 at 10:48 PM
#OTILT Antibiotic treatment of Enterococcus spp. is more clinically important in immunocompromised patients that have intra-abdominal infections. pmc.ncbi.nlm.nih.gov/articles/PMC...
@bwdionne.bsky.social @cheungalison.bsky.social @jeffpears0n.bsky.social
@bwdionne.bsky.social @cheungalison.bsky.social @jeffpears0n.bsky.social
#OTILT TMP/SMX is recommended as prophylaxis for PCP prevention in patients with solid organ transplant recipients, those using high doses of steroids, and HIV. @cheungalison.bsky.social @bwdionne.bsky.social @jeffpears0n.bsky.social academic.oup.com/ofid/article...
August 11, 2025 at 7:15 PM
#OTILT TMP/SMX is recommended as prophylaxis for PCP prevention in patients with solid organ transplant recipients, those using high doses of steroids, and HIV. @cheungalison.bsky.social @bwdionne.bsky.social @jeffpears0n.bsky.social academic.oup.com/ofid/article...
#OTILT Candida albicans is a diploid gram positive fungus that can switch between phenotypes. One phenotype is a white round cell while the other phenotype form is rod shaped, opaque, and flat in gray colonies. @cheungalison.bsky.social @bwdionne.bsky.social
microchemlab.com/microorganis....
microchemlab.com/microorganis....
August 8, 2025 at 8:58 PM
#OTILT Candida albicans is a diploid gram positive fungus that can switch between phenotypes. One phenotype is a white round cell while the other phenotype form is rod shaped, opaque, and flat in gray colonies. @cheungalison.bsky.social @bwdionne.bsky.social
microchemlab.com/microorganis....
microchemlab.com/microorganis....
#OTILT The annulus is a ring like structure or a body part that is shaped like a ring. In the heart, the annulus is a ring of fibrous tissue that is around the base of the valve. @bwdionne.bsky.social @cheungalison.bsky.social
pmc.ncbi.nlm.nih.gov/articles/PMC...).
pmc.ncbi.nlm.nih.gov/articles/PMC...).
August 7, 2025 at 10:05 PM
#OTILT The annulus is a ring like structure or a body part that is shaped like a ring. In the heart, the annulus is a ring of fibrous tissue that is around the base of the valve. @bwdionne.bsky.social @cheungalison.bsky.social
pmc.ncbi.nlm.nih.gov/articles/PMC...).
pmc.ncbi.nlm.nih.gov/articles/PMC...).
#OTILTPart2 Most cases of endogenous endophthalmitis are predominantly caused by candida species while exogenous endophthalmitis usually occur after scleral buckling, contact lens, and post LASIK surgery. @cheungalison.bsky.social @bwdionne.bsky.social www.ncbi.nlm.nih.gov/books/NBK559....
Endophthalmitis
Endophthalmitis is defined as an inflammation of the inner coats of the eye, resulting from intraocular colonization of infectious agents with exudation within intraocular fluids (vitreous and aqueous...
www.ncbi.nlm.nih.gov
August 6, 2025 at 8:47 PM
#OTILTPart2 Most cases of endogenous endophthalmitis are predominantly caused by candida species while exogenous endophthalmitis usually occur after scleral buckling, contact lens, and post LASIK surgery. @cheungalison.bsky.social @bwdionne.bsky.social www.ncbi.nlm.nih.gov/books/NBK559....
#OTILTPart1 On August 16th, 1944 John Logie Baird gave the world's first demonstration of a picture tube. This device not only created color pictures but also images in 3D. @cheungalison.bsky.social @bwdionne.bsky.social www.scienceandmediamuseum.org.uk/objects-and-....
The history of colour TV in the UK | National Science and Media Museum
Find out about the history of colour TV in the UK, including the inventions that led to its introduction, the first broadcasts in Britain, and how people watched early colour television programmes.
www.scienceandmediamuseum.org.uk
August 6, 2025 at 8:33 PM
#OTILTPart1 On August 16th, 1944 John Logie Baird gave the world's first demonstration of a picture tube. This device not only created color pictures but also images in 3D. @cheungalison.bsky.social @bwdionne.bsky.social www.scienceandmediamuseum.org.uk/objects-and-....
#OTILT CRP and ESR are diagnostic tests that are used to detect inflammatory conditions. CRP rises within in an hour of infection but ESR increases in a slow manner. @bwdionne.bsky.social @cheungalison.bsky.social www.ncbi.nlm.nih.gov/books/NBK333...
Introduction
Patients who have suspected inflammatory disease or serious infection may undergo a diagnostic workup that involves multiple laboratory tests. Two such laboratory tests are erythrocyte sedimentation r...
www.ncbi.nlm.nih.gov
August 6, 2025 at 2:05 AM
#OTILT CRP and ESR are diagnostic tests that are used to detect inflammatory conditions. CRP rises within in an hour of infection but ESR increases in a slow manner. @bwdionne.bsky.social @cheungalison.bsky.social www.ncbi.nlm.nih.gov/books/NBK333...
#OTILT Sulfamethoxazole component of sulfamethoxazole-trimethoprim was found to be nephrotoxic at higher doses and the trimethoprim component was found to inhibit tubular creatinine secretion. @bwdionne.bsky.social @cheungalison.bsky.social
pubmed.ncbi.nlm.nih.gov/21832843/
pubmed.ncbi.nlm.nih.gov/21832843/
Trimethoprim, creatinine and creatinine-based equations - PubMed
Co-trimoxazole is a frequently prescribed antibiotic worldwide. It is composed of both trimethoprim and sulfamethoxazol (Sfx) and is used in the treatment and prophylaxis of urinary tract and Pneumocy...
pubmed.ncbi.nlm.nih.gov
August 4, 2025 at 10:45 PM
#OTILT Sulfamethoxazole component of sulfamethoxazole-trimethoprim was found to be nephrotoxic at higher doses and the trimethoprim component was found to inhibit tubular creatinine secretion. @bwdionne.bsky.social @cheungalison.bsky.social
pubmed.ncbi.nlm.nih.gov/21832843/
pubmed.ncbi.nlm.nih.gov/21832843/
#OTILT PICC lines are useful for chemotherapy, IV medications, blood transfusions, IV fluids, and for taking blood samples. While having a PICC line, it is important to avoid contact sports and carrying heavy objects. @bwdionne.bsky.social @cheungalison.bsky.social
www.mskcc.org/cancer-care/...
www.mskcc.org/cancer-care/...
About Your Peripherally Inserted Central Catheter (PICC)
This information explains what a PICC is and how it’s placed. It also has guidelines for caring for your PICC at home. A PICC is a type of central venous catheter (CVC).
www.mskcc.org
August 1, 2025 at 5:27 PM
#OTILT PICC lines are useful for chemotherapy, IV medications, blood transfusions, IV fluids, and for taking blood samples. While having a PICC line, it is important to avoid contact sports and carrying heavy objects. @bwdionne.bsky.social @cheungalison.bsky.social
www.mskcc.org/cancer-care/...
www.mskcc.org/cancer-care/...
#OTILT CPK values are the most sensitive indicator of rhabdomyolysis with levels ranging from 26 to 308 U/L. CPK elevations that are 5 times the upper limit of normal are considered suggestive of rhabdomyolysis pmc.ncbi.nlm.nih.gov/articles/PMC... @cheungalison.bsky.social @bwdionne.bsky.social
Physiologic Response to Exercise or Rhabdomyolysis? Creatine Phosphokinase Elevation in 16 Asymptomatic Firefighters
Case series Patients: 22-year-old • 29-year-old • 27-year-old • 28-year-old Final Diagnosis: Creatine-kinase elevation • rhabdomyolysis Symptoms: Creatine-kinase elevation • exercise intolerance • hem...
pmc.ncbi.nlm.nih.gov
July 31, 2025 at 11:26 PM
#OTILT CPK values are the most sensitive indicator of rhabdomyolysis with levels ranging from 26 to 308 U/L. CPK elevations that are 5 times the upper limit of normal are considered suggestive of rhabdomyolysis pmc.ncbi.nlm.nih.gov/articles/PMC... @cheungalison.bsky.social @bwdionne.bsky.social
#OTILT People who inject drugs are 16.3 times more likely to develop MRSA infections than others. This could be prevented through the use of syringe services and prevention of opioid misuse. @cheungalison.bsky.social @bwdionne.bsky.social
www.cdc.gov/mmwr/volumes...
www.cdc.gov/mmwr/volumes...
Invasive Methicillin-Resistant Staphylococcus aureus...
In the United States, age-adjusted opioid overdose death rates increased by >200% during 1999–2015, and heroin overdose death rates increased nearly 300% during 2011–2015.
www.cdc.gov
July 30, 2025 at 8:16 PM
#OTILT People who inject drugs are 16.3 times more likely to develop MRSA infections than others. This could be prevented through the use of syringe services and prevention of opioid misuse. @cheungalison.bsky.social @bwdionne.bsky.social
www.cdc.gov/mmwr/volumes...
www.cdc.gov/mmwr/volumes...