Christoph Häfelfinger
@chrismhafelfinger.bsky.social
PhD Student at the Francis Crick Institute (Santos Lab for Quantitative Stem Cell Biology)
Reposted by Christoph Häfelfinger
Now online! Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development
Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development
An embryonic stem cell-based 3D model that accurately recapitulates the size, morphology, and functional features of the human amnion at 4 weeks, termed the post-gastrulation amnioid (PGA), is developed. The model’s reproducibility and scalability make it ideal for studying amniogenesis and for clinical applications that use human amniotic sac membranes.
dlvr.it
May 15, 2025 at 2:59 PM
Now online! Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development
Reposted by Christoph Häfelfinger
Beautiful work from @santoslab.bsky.social
A 3D model of human amnion from hESCs
These recapitulate amniotic sac development, revealing GATA3 as key amniogenesis driver & autoregulatory BMP/Wnt feedback loops
And check out the size of them in the video
www.cell.com/cell/fulltex...
A 3D model of human amnion from hESCs
These recapitulate amniotic sac development, revealing GATA3 as key amniogenesis driver & autoregulatory BMP/Wnt feedback loops
And check out the size of them in the video
www.cell.com/cell/fulltex...
Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development
An embryonic stem cell-based 3D model that accurately recapitulates the size, morphology,
and functional features of the human amnion at 4 weeks, termed the post-gastrulation
amnioid (PGA), is develop...
www.cell.com
May 15, 2025 at 4:17 PM
Beautiful work from @santoslab.bsky.social
A 3D model of human amnion from hESCs
These recapitulate amniotic sac development, revealing GATA3 as key amniogenesis driver & autoregulatory BMP/Wnt feedback loops
And check out the size of them in the video
www.cell.com/cell/fulltex...
A 3D model of human amnion from hESCs
These recapitulate amniotic sac development, revealing GATA3 as key amniogenesis driver & autoregulatory BMP/Wnt feedback loops
And check out the size of them in the video
www.cell.com/cell/fulltex...