Chris Lengerich
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chrislengerich.com
Chris Lengerich
@chrislengerich.com
How do we make scientists and engineers 100x more productive to solve problems that matter?

This feed is notebook margins - raw research notes to train a science hypothesis AI later.

Final essays go to Context Fund: https://www.reddit.com/r/contextfund
Ready player none
December 9, 2025 at 8:53 AM
Confused middle = middle section of the bell curve meme:
imgflip.com/memegenerato...
Bell Curve Meme Generator - Imgflip
Insanely fast, mobile-friendly meme generator. Make Bell Curve memes or upload your own images to make custom memes
imgflip.com
November 7, 2025 at 4:06 AM
Why it took 12 years to get here will never fully understand, but still, we're here now.
September 21, 2025 at 1:00 AM
Also, no excuse anymore to miss important global trends (via universal translation + summarization):
September 3, 2025 at 5:37 AM
[3] One of my FE friends from Coursera used to reskin every site he used; easy to do this for the average user now. The web isn't usable by default, like it was a decade ago, but with a couple config changes, it can be.
August 28, 2025 at 5:39 PM
[2] Newsfeed eradicator extension + Brave's block element works well for enforcing a "no newsfeed" policy.
August 28, 2025 at 5:39 PM
[1] One month to Q3 notes!
August 28, 2025 at 5:34 PM
So if you leverage fast APIs for creativity and raise <$100M for wetlab verification, you could discover highly defensible windfalls, especially for indications like aging, a market projected to be 4x bigger ($200B annually) than the market for GLP-1 (www.librariesforthefuture.bio/p/tam-aging-...).
$200 Billion in Revenue: How an Aging Drug Will Conquer Pharma
An aging drug is a drug that has been rigorously shown to increase healthy lifespan in people, with emphasis on the ability to extend quality of life. The economics of delivering such value to human h...
www.librariesforthefuture.bio
August 9, 2025 at 11:06 PM
While drug discovery is more expensive than consumer tech to start, it arguably has a better M&A market (not all or nothing), (chatgpt.com/share/68979e..., even non-accredited investors can buy patents).
ChatGPT - Patent process for molecules
Shared via ChatGPT
chatgpt.com
August 9, 2025 at 11:00 PM
Only a handful of (problem, solution) pairs will go on to truly become global APIs, but adding a diversity of cross-terms via fast exploration really could matter to exploration-bounded problems (drug discovery, especially).

Also, one of the lessons of the DCN (arxiv.org/abs/1708.05123).
Deep & Cross Network for Ad Click Predictions
Feature engineering has been the key to the success of many prediction models. However, the process is non-trivial and often requires manual feature engineering or exhaustive searching. DNNs are able to automatically learn feature interactions; however, they generate all the interactions implicitly, and are not necessarily efficient in learning all types of cross features. In this paper, we propose the Deep & Cross Network (DCN) which keeps the benefits of a DNN model, and beyond that, it introduces a novel cross network that is more efficient in learning certain bounded-degree feature interactions. In particular, DCN explicitly applies feature crossing at each layer, requires no manual feature engineering, and adds negligible extra complexity to the DNN model. Our experimental results have demonstrated its superiority over the state-of-art algorithms on the CTR prediction dataset and dense classification dataset, in terms of both model accuracy and memory usage.
arxiv.org
August 9, 2025 at 10:43 PM
With 0 friction from verifiers (inner economy only), leading to 1000x speedup in cognitive labor, this could lead 1E6x greater diversity.
August 9, 2025 at 10:41 PM
Seems crazy, but if we're accelerating cognitive labor, say by about, 3x now, and this is linearly related to diversity of labor (questionable, \propto number of semantic or dynamic branches you can take in a space), we could see 9x greater pairwise diversity (of problems, of solutions, etc.)
August 9, 2025 at 10:39 PM
Experiments like prediction markets stand out here re: making a market for verification (can have both good and bad effects), but are probably worth experimenting with around a variety of scientific topics. However, still need to reduce friction 1000x and allow the long-tail growth to scale up.
August 9, 2025 at 9:49 PM
On the other hand, humans with AI tools which create more info about the world may be good at creating new asset classes (longer-duration, hedged instruments, etc.) to the extent permissible by regulators.

Slowly-traded markets with better IP protection especially.
August 9, 2025 at 9:20 PM
Quite curious to see how this plays out in the inner (AI-only) economy (my guess is, far more efficiently, due to differentiability (often) rather than approximating a gradient with stories (no story, no gradient).
August 9, 2025 at 8:08 PM
In the past, though, it was the opposite default - high friction, lots of local monopolies.
August 9, 2025 at 8:00 PM