chihyao.bsky.social
@chihyao.bsky.social
Reposted
🧬 Looking for a PhD position in molecular or developmental biology? 🔬

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July 10, 2025 at 11:19 AM
Reposted
Pathogenic variants in autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.05.23.655806v1
May 29, 2025 at 7:01 AM
Reposted
Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function

www.tandfonline.com/doi/full/10....
Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function
Mitochondrial DNA (mtDNA) encodes genes essential for oxidative phosphorylation. The m.3243A>G mutation causes severe disease, including myopathy, lactic acidosis and stroke-like episodes (MELAS) a...
www.tandfonline.com
December 13, 2024 at 8:09 PM