Peter Chien
@chienlab.bsky.social
Looking at small things making small things even smaller. UMass Amherst Biochemistry. Microbiology. Views are my own. He/him
I find its super cool that different bacteria have different ways of making different dnaX versions (transcriptional and proteolysis!) The reduced genome aspect is interesting....
August 24, 2025 at 7:33 PM
I find its super cool that different bacteria have different ways of making different dnaX versions (transcriptional and proteolysis!) The reduced genome aspect is interesting....
Will see you there!! ( with alums of your lab!)
August 3, 2025 at 12:30 AM
Will see you there!! ( with alums of your lab!)
FYI, Jr lab was the big lab course in physics major so Sarah and I spent waaay too much time in cold radio telescope control rooms!
June 28, 2025 at 7:49 PM
FYI, Jr lab was the big lab course in physics major so Sarah and I spent waaay too much time in cold radio telescope control rooms!
We had such a fantastic time hearing all about you and your team! So excited to have you visit!
April 30, 2025 at 8:32 PM
We had such a fantastic time hearing all about you and your team! So excited to have you visit!
huh, really wacky - the lack of ATP dependence is also weird... thanks for calling it out!
February 14, 2025 at 8:21 PM
huh, really wacky - the lack of ATP dependence is also weird... thanks for calling it out!
I am so curious about other pronunciations of codon!
February 12, 2025 at 12:36 AM
I am so curious about other pronunciations of codon!
I appreciate the challenges of leadership in this complex and chaotic environment, the EOs seem to empower going after non-federal groups in a way that is chilling. But having the trust of the membership is paramount for any society.
February 5, 2025 at 11:15 AM
I appreciate the challenges of leadership in this complex and chaotic environment, the EOs seem to empower going after non-federal groups in a way that is chilling. But having the trust of the membership is paramount for any society.
Explaining more about reasoning, process and what will happen with any future actions is also an important task for society leadership.
February 5, 2025 at 11:15 AM
Explaining more about reasoning, process and what will happen with any future actions is also an important task for society leadership.
I will continue to review for society journals because I still feel that it is one of the best forums for people to have their work evaluated and read by their peers. But, clear communication with the society members is needed for the kinds of changes that were made (before they are made).
February 5, 2025 at 11:15 AM
I will continue to review for society journals because I still feel that it is one of the best forums for people to have their work evaluated and read by their peers. But, clear communication with the society members is needed for the kinds of changes that were made (before they are made).
Like many, I do NOT love the recent bungling they did with their website nor the press release after the fact. I absolutely still believe in the purpose of the society to support its broad and diverse membership (which drew me to it in the first place).
February 5, 2025 at 11:15 AM
Like many, I do NOT love the recent bungling they did with their website nor the press release after the fact. I absolutely still believe in the purpose of the society to support its broad and diverse membership (which drew me to it in the first place).
We published in J Bacteriology because I love society journals, appreciate the work of the editors (our peers!) and strongly believe in @asm.org as a membership society.
February 5, 2025 at 11:15 AM
We published in J Bacteriology because I love society journals, appreciate the work of the editors (our peers!) and strongly believe in @asm.org as a membership society.
first off, how did you get Caulobacter contaminants? 👀 We have a durned time growing them when we want to some time. We did end up connecting Lon with heme through the control of the FixT pathway, but the physiological impact of this is still mysterious! (pubmed.ncbi.nlm.nih.gov/38940598/)
Proteolytic control of FixT by the Lon protease impacts FixLJ signaling in Caulobacter crescentus - PubMed
The Lon protease shapes protein quality control, signaling pathways, and stress responses in many bacteria species. Loss of Lon often results in multiple phenotypic consequences. In this work, we foun...
pubmed.ncbi.nlm.nih.gov
February 5, 2025 at 10:46 AM
first off, how did you get Caulobacter contaminants? 👀 We have a durned time growing them when we want to some time. We did end up connecting Lon with heme through the control of the FixT pathway, but the physiological impact of this is still mysterious! (pubmed.ncbi.nlm.nih.gov/38940598/)
Great question. We think one aspect is about repairing DNA damage! We have a preprint on this in the context of chromosomal DNA binding www.biorxiv.org/content/10.1...
A legacy role for DNA binding of Lon protects against genotoxic stress
DNA binding proteins are essential for cellular life, but persistently bound complexes have toxic consequences. Here we show that the proteotoxic responsive bacterial protease Lon clears proteins from...
www.biorxiv.org
December 11, 2024 at 1:56 PM
Great question. We think one aspect is about repairing DNA damage! We have a preprint on this in the context of chromosomal DNA binding www.biorxiv.org/content/10.1...