Not quite for use in motor oil but

I wonder how many chemical families we abandoned for good toxicological reasons could help solve modern problems unforeseen at the time. Imagine if DDT scavenged CO2 and methane from the atmosphere or something absurd like that!

I was doing some research on passive daytime radiative sky cooling and lead white has an excellent emission spectrum in the infrared window particularly when compared to titanium zinc white, yet we obviously don't want to use lead paint!

Wow that kinda sucks wrt lead being the source of the effect. Lead is such a cool and useful element and its compounds are so profoundly useful if it just wasn't so toxic!

Kinda playing fast and loose on an anti-knock compound here. No idea whether this would even work at all in a real engine, and whether this should be an ethyl ester rather than acetate. Bond angles are also probably fucked. Oh well!

That's more of a nice-to-have though, and I have leftover NTFS drives from when I switched to Linux fully that I still use and have survived multiple reinstalls, so don't worry about it unless you wanna tinker.

One thing I don't see mentioned here is that BTRFS allows you to transparently compress files on the fly way better than NTFS' compression (which I'm not even sure linux supports), which can lead to some serious space savings if the files are compressible. Not so useful for media, however.

Considering how close estradiol is to cholesterol, which is fat soluble, that should've been obvious tbh.

I honestly just assumed we must be injecting esters not just for the extended half-life over the course of hydrolysis, but also because of estradiol solubility issues in triglycerides due to the alcohol groups. Now that I think about it though, if that was the case, why not just inject via water?

Wow, that's crazy. I hadn't really looked into this much before but that's really cool!

Maybe we could have one fluorocarbon tail and two fatty acid tails to act as a surfactant/emulsifier/compatibilizer between the fluoroestradiol ester and the triglyceride oil? That would increase toxicity over baseline but ensure solubility in a less-toxic carrier.

Actually, how does the body even suspend triglycerides in blood or the intracellular matrix in general? I'm no biochemist so I'm out of my depth here (for now).

Hmmm... good point.

Also yes I know this is technically estradiol nitrate but if nitroglycerin gets the title so does she 😤

Alternative title: estrogen that makes you a literal bombshell

Hold up, this wouldn't dissolve in triglycerides, so you'd need a fluorinated triacylglyceride, which would probably push us into immediately lethal and certainly carcinogenic realms for a single injection. TODO: math

MY TIME HAS COME!

Any compounding pharmacists wanna hit me up? 😘