It appears that I won’t be able to penetrate your cheekiness. Happy to have an informed discussion about the necessity for intermediate endpoints when using probabilistic refutation to model falsification of a testable hypothesis, if you come around.

“just don't try to get definitive answers at each single study”
🧐
Gotcha, so just like catch vibes about the Null in individual studies. Doesn’t sound like too much of a reproducible test, but hey to each their own.😃

If a hypothesis isn’t falsifiable (yes/no) it isn‘t scientific. The predictive capacity of findings is an aspect of experimental design that should be adjusted based on the level of certainty you aim to achieve in modeling of a specific case. However science isn’t the only way to evaluate phenomena.

Are you taking temperature measurements of the waters where you find them?

Thank you for the excellent primer, I learned a lot!

I wonder if it would it be possible to use MERFISH to predict the likelyhood of a mRNA's translation by ratiometric analysis of its proximity to tRNAs?

An image I took for this project – of a granuloma Langhans MGC expressing OPN – is featured on the cover of the October 2025 issue of mBio!

journals.asm.org/toc/mbio/16/10

We need to act now or all of Portland will be lost beyond the Powell's singularity event horizon!

Sorry for the misunderstanding, this dataset is human genes in M.tb granulomas taken from people with TB.

For granuloma specific Mycobacterial genes please see my colleague Gopi Viswanathan‘s excellent recent preprint!

www.biorxiv.org/content/10.1...

Fig.S16 names names

Data rich for your enjoyment!

3 RNAseq datasets. Spatial and single-cell from clinical biopsies of human M.tuberculosis granulomas plus flow sorted macrophage bulk RNAseq from M.marinum-infected zebrafish larvae. Bonus functional validations in the adult zebrafish model.

“Generative AI designs high-specificity pMHC-binding artificial TCRs for more precise targeting of tumor antigen”?

Treat it as an opportunity to expound on your scientific philosophy within the context of your dissertations central question. This is assuming you're working towards a doctorate of philosophy in your chosen field. Write it as a synthesis essay.

Why is the Northern Irish line green? That border was established in 1921.