Charleston Chiang
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charleston.bsky.social
Charleston Chiang
@charleston.bsky.social
Associate Professor at USC, Center for Genetic Epidemiology. Population genetics, statistical genetics & human genetics/genetic epidemiology. A city, mountain, dance, candy & a drosophila gene. UCLA->Harvard->UCLA->USC.

http://chianglab.usc.edu
"Genetic genealogy-based approach enhances the discovery of trait associated loci in small-sample populations" from @bryandinh.bsky.social:

drive.google.com/file/d/1UY-P...

That's a wrap, #ASHG25!
October 18, 2025 at 4:10 AM
"An evaluation of the prediction accuracy for polygenic score models across thirteen quantitative biomarkers and anthropometric measures in Native Hawaiians" from Kimberli Alatorre. Kimberli is a postbac in her first research experience!

drive.google.com/file/d/1t-rg...
October 18, 2025 at 4:10 AM
and.. "Incorporating Dietary Information to Enhance Polygenic Prediction Models with Applications to Body Mass Index and Type 2 Diabetes" from Eunice Lee:

drive.google.com/file/d/1gU63...
October 16, 2025 at 4:21 AM
First day of poster session is done! If you missed our poster but still want to check it out, you can use the link here!

"Pattern of genetic variation and enrichment of functional alleles in Native Hawaiians" from @jitang1024.bsky.social :

drive.google.com/file/d/1LWfy...
October 16, 2025 at 4:21 AM
Thanks to the weather I've spent more time at O'Hare than #ASHG25 so far, but I'm now ready to go!

As usual, our research is well-represented at #ASHG2025, with four trainees presenting the advances in their research from this past year. Please go bombard them with your questions!
October 15, 2025 at 1:19 PM
This manuscript is a part towards that goal, where we showed under-performance of PGS models for Native Hawaiians. Presence of admixture masked this somewhat, thus creating some disparity even within the population.
May 6, 2025 at 4:04 PM
“I don’t think [my research is] something the New Republic would be interested in.”

How eerily ominous…
(No, I’m way behind on Star Wars shows… i don’t know what is going to happen. This scene just struck a nerve.)

#thisistheway
February 5, 2025 at 5:12 AM
Bluesky now has over 10 million users, and I was #414,560!
September 29, 2024 at 9:40 AM
As I turned on airplane mode going to the TAGC 2024 conference, I missed an email from the Dean... I was too cheap to pay $39.99 in-flight for internet so you can imagine the jitter for that 4-hr flight.

Always envious of those tenure-with-Death-Star-Lego photos.. did I go overboard here?
March 14, 2024 at 3:41 PM
Happy Halloween! I’ve waited two years to do this - Mendel and his pea!
November 1, 2023 at 4:14 AM
Apparently I’m also a cookie… in addition to being a city, mountain, candy, dance, and drosophila gene.
October 15, 2023 at 4:56 PM
We applied the method to empirical data from Latinos and Native Hawaiians. We note results should be interpreted cautiously, as we did not have access to high quality sequencing data for these understudied admixed populations, and tree reconstruction methods can still improve!
October 14, 2023 at 1:27 AM
We also benchmarked the methods on complicated models from stdpopsim, e.g. those with exponential growth and those with ancient samples from within-continent admixtures – gLike are all much more accurate and precise in general.
October 14, 2023 at 1:27 AM
In simulations, gLike accurately estimated the demographic parameter of multi-way admixed populations using the true trees. The performance was a little worse when inferred trees (by tsdate) were used, but still appears to be much better than site-frequency-based methods.
October 14, 2023 at 1:27 AM
We devised a method called gLike that derives the full likelihood of a genealogical tree. It uses a graph-based structure to trace each lineage in a tree through all possible trajectories of population memberships over time and computes the exact marginal probability.
October 14, 2023 at 1:26 AM
Maybe a little late to the game, and don't know the norm practices on new platforms now... but if you are interested in the type of research we do, please check out our lab webpage!

chianglab.usc.edu

(We are looking for students, postdocs, and/or staff scientists too!)
August 21, 2023 at 4:36 PM