Key finding #5: Potential for dengue virus strain selection following Wolbachia interventions, with selection for few strains with a high average relative dissemination 📈

Key finding #4: Differential Wolbachia inhibition results in increased probability of dengue virus reemergence, particularly in high transmission intensity settings 💻

Key finding #3: Differential inhibition of the four dengue virus serotypes, with the least inhibition of many DENV-3 isolates in both Wolbachia strains 🧬

Key finding #2: Overall stronger inhibition by wMelM as compared to wAlbB 🦠

Key finding #1: High level of variability in dengue virus dissemination ranging from 0-100%, even in the absence of Wolbachia 🦟

We tested inhibition of 60 dengue virus isolates by two Wolbachia strains (wAlbB and wMelM) in Aedes aegypti mosquitoes. To explore the epidemiological implications of our findings, we used our experimental data to inform stochastic transmission models.

This project was a huge collaborative effort with @mallerybreban.bsky.social @ebourgikos.bsky.social Braiya Nolan, Nicole Feriancek @isabelott.bsky.social Julian Bakker @viralverity.bsky.social @perran.bsky.social Xinyue Gu @huangat.bsky.social @hsalje.bsky.social and @nathangrubaugh.bsky.social 💪