Chang Liu
@chang-c-liu.bsky.social
Prof. at UC Irvine developing specialized genetic systems for rapid evolution, protein engineering, and biology at large. Also at https://x.com/chang_c_liu
www.liulab.com
www.liulab.com
I'm so sorry. May her memory be a blessing.
October 31, 2025 at 10:57 PM
I'm so sorry. May her memory be a blessing.
The result is a rich sequence-affinity dataset spanning both a range of sequences and affinities. We are now scaling these approaches, including to antibodies and a broad array of targets, to get the right distribution and volume of data for training generative models for binder design.
October 28, 2025 at 7:33 AM
The result is a rich sequence-affinity dataset spanning both a range of sequences and affinities. We are now scaling these approaches, including to antibodies and a broad array of targets, to get the right distribution and volume of data for training generative models for binder design.
One way we arrive at diverse evolutionary outcomes is through "neutral drift" where we take one binder and diverge it into many by selecting for the maintenance of (but not improvement of) binding. This is very easy to do with OrthoRep because rapid mutation of the binder occurs autonomously.
October 28, 2025 at 7:33 AM
One way we arrive at diverse evolutionary outcomes is through "neutral drift" where we take one binder and diverge it into many by selecting for the maintenance of (but not improvement of) binding. This is very easy to do with OrthoRep because rapid mutation of the binder occurs autonomously.
Love it! Congrats Jeff and team!
August 18, 2025 at 4:08 PM
Love it! Congrats Jeff and team!
We find that low copy number accelerates fixation of beneficial mutants while high copy number lets more deleterious alleles hitchhike in cells with fit alleles. High copy number also promotes a form of functional robustness through maintenance of allelic diversity.
July 15, 2025 at 8:47 PM
We find that low copy number accelerates fixation of beneficial mutants while high copy number lets more deleterious alleles hitchhike in cells with fit alleles. High copy number also promotes a form of functional robustness through maintenance of allelic diversity.
Congrats Olek and Alireza!
May 6, 2025 at 6:23 PM
Congrats Olek and Alireza!
Going forward, we’ll be using this system, ORACLE (OrthoRep Assisted Continuous Library Evolution), to find evolutionary innovations from more libraries against more additional selection pressures in service of both the basic understanding of gene evolution and applications.
May 6, 2025 at 6:23 PM
Going forward, we’ll be using this system, ORACLE (OrthoRep Assisted Continuous Library Evolution), to find evolutionary innovations from more libraries against more additional selection pressures in service of both the basic understanding of gene evolution and applications.
We hope the abundance of examples we provide where unexpected genes evolve new function will update views on the likeliness of originating new biomolecular functions in nature.
May 6, 2025 at 6:23 PM
We hope the abundance of examples we provide where unexpected genes evolve new function will update views on the likeliness of originating new biomolecular functions in nature.
...when the diversity of genes available as sources of new function is large and when the systems level complexity of cells is available to afford multiple routes to new selectable phenotypes.
May 6, 2025 at 6:23 PM
...when the diversity of genes available as sources of new function is large and when the systems level complexity of cells is available to afford multiple routes to new selectable phenotypes.
Reposted by Chang Liu
My story: I’m a single father and cancer researcher whose wife died of a rare cancer. Science and biomedical research is personal to me. Here is my op-ed in my hometown newspaper. Pls fwd.
www.vindy.com/opinion/edit...
www.vindy.com/opinion/edit...
DOGE ends America’s golden age of biomedical research
Biomedical research impacts all of us. I became curious about how drugs work after my mom was diagnosed with rheumatoid arthritis when I was a small boy. She received “gold shots” as treatment, which ...
www.vindy.com
March 17, 2025 at 9:29 PM
My story: I’m a single father and cancer researcher whose wife died of a rare cancer. Science and biomedical research is personal to me. Here is my op-ed in my hometown newspaper. Pls fwd.
www.vindy.com/opinion/edit...
www.vindy.com/opinion/edit...