monitoring the situation as a shipment of precious chordoma samples from our biobank flys to Melbourne for our collaborators in the Firestein lab at @hudsonresearch.bsky.social ✈️ 🇦🇺

Finally, Tyler Vincent presented a poster describing a suite of new capabilities we've developed to enable the identification, optimization and validation of TBXT (brachyury) targeted molecules. Honored this won best poster in the Basic Science category. chordomafoundation.imgix.net/2024_CF_TBXT...

In a poster our CSO Dan Freed presented findings that chordoma cell lines exhibit striking differential sensitivity to afatinib, which is associated with interferon (IFN) signaling. Honored this won best in the Tumor Heterogeneity and Resistance category. chordomafoundation.imgix.net/CTOS_EGFRi-b...

Building on recent findings that GPX4 is a genetic essentiality in chordoma, we’ve demonstrated that GPX4 inhibition induces ferroptotic cell death, suggesting #ferroptosis susceptibility may be a targetable vulnerability in chordoma. Results now on Figshare:
figshare.com/articles/fig...

We're studying replication stress in chordoma, and have recently identified several therapeutic approaches that exploit this vulnerability. Here are 3 new figures we’ve put on Figshare to enable others to build on our findings before they’re published. 👇