Katerina Cermakova
@cermakova.bsky.social
How does the cBAF complex use disordered protein to engage diverse transcriptional regulators like YAP1, SOX2, and CBP/p300? Our new Mol Cell paper reveals β-catenin’s role as a molecular adapter
How do chromatin remodelers use #IDRs to find TF binding partners? In our new Molecular Cell paper, we show that β-catenin is an adaptor that links SWI/SNF (cBAF) subunit ARID1A with binding partners via IDR-domain interactions.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
July 22, 2025 at 6:55 PM
How does the cBAF complex use disordered protein to engage diverse transcriptional regulators like YAP1, SOX2, and CBP/p300? Our new Mol Cell paper reveals β-catenin’s role as a molecular adapter
For the first time, we find a common mechanism for SWI/SNF addiction in cancer! Our paper reveals that G1 phase is a critical junction for SWI/SNF activity in several addicted cancers, including neuroblastoma, AML, prostate cancer, and uveal melanoma academic.oup.com/nar/advance-... (1/6)
November 27, 2023 at 2:17 PM
For the first time, we find a common mechanism for SWI/SNF addiction in cancer! Our paper reveals that G1 phase is a critical junction for SWI/SNF activity in several addicted cancers, including neuroblastoma, AML, prostate cancer, and uveal melanoma academic.oup.com/nar/advance-... (1/6)