@bowers-wbhi.bsky.social

I'm so sorry, this is so bad..

A huge thank you to all of my co-authors, especially to my extraordinary mentors Amy Kuceyeski @amykooz.bsky.social
and Susan Gauthier! (8/8)

Our work suggests that a more aggressive disease phenotype in patients with MS having PRLs may be linked to heightened inflammatory activity in WM tracts disrupted by these pathologic lesions. (7/8)

Elevated inflammatory activity in highly disrupted WM tracts was associated with increased disability in patients with PRL, but not in patients without PRL. (6/8)

Compared to patients without PRL, patients with PRLs exhibited higher levels of inflammation in the WM highly disrupted by any type of MS lesions or PRLs. In patients with PRL, inflammation was higher in WM highly disrupted by PRLs compared to WM highly disrupted by non-PRLs. (5/8)

MS patients had higher inflammatory activity in whole brain WM compared to healthy controls. Patients with PRLs demonstrated relatively greater DVR than patients without PRL. (4/8)