Thomas Guiziou
@cen0ten.bsky.social
PhD Student in the Vorobieva Lab in de novo protein design
what for ? If I code as well as the llm, why need to use it
November 29, 2025 at 11:07 AM
what for ? If I code as well as the llm, why need to use it
By only using LLM one risk to only be as good as the tool. Which to me feels like a liability on the job market
November 27, 2025 at 10:02 PM
By only using LLM one risk to only be as good as the tool. Which to me feels like a liability on the job market
the question is more, what do you learn when you use the LLMs ?
Sure you boost your short term productivity, but what about long term understanding and productivity ?
Personally I need to understand very well the basic to be able to build on top of it.
Sure you boost your short term productivity, but what about long term understanding and productivity ?
Personally I need to understand very well the basic to be able to build on top of it.
November 27, 2025 at 10:01 PM
the question is more, what do you learn when you use the LLMs ?
Sure you boost your short term productivity, but what about long term understanding and productivity ?
Personally I need to understand very well the basic to be able to build on top of it.
Sure you boost your short term productivity, but what about long term understanding and productivity ?
Personally I need to understand very well the basic to be able to build on top of it.
In the pursuit of the origin of life, the definition of life is not important. But in the pursuit of a strong theoretical base for biology, the definition of life should be important. Which I think should concern most of biologist.
November 26, 2025 at 3:37 PM
In the pursuit of the origin of life, the definition of life is not important. But in the pursuit of a strong theoretical base for biology, the definition of life should be important. Which I think should concern most of biologist.
Yet, for biologist, it should be important to define what we are working on. One would assume it is essential to have a good theoretical base to the science.
November 26, 2025 at 3:26 PM
Yet, for biologist, it should be important to define what we are working on. One would assume it is essential to have a good theoretical base to the science.
Cristals fit in this definition and are not considered alive by most, so I would agree
November 26, 2025 at 3:08 PM
Cristals fit in this definition and are not considered alive by most, so I would agree
very nice figure, is it from the chroma paper ?
November 16, 2025 at 9:36 PM
very nice figure, is it from the chroma paper ?
yes, and the same can be said about artists
November 16, 2025 at 8:45 PM
yes, and the same can be said about artists
one of my former PI did his primer design on word document and kept all of his plasmid sequences on word documents
November 16, 2025 at 4:20 PM
one of my former PI did his primer design on word document and kept all of his plasmid sequences on word documents
It should be it isn't, thus we would hold said tool to a higher standard than our own research which does not make sense.
When publishing a paper, do we estimate the carbon footprint or pollution ? And then compare it to the societal gains ? When we do we can then ask the same to other.
When publishing a paper, do we estimate the carbon footprint or pollution ? And then compare it to the societal gains ? When we do we can then ask the same to other.
November 7, 2025 at 12:16 PM
It should be it isn't, thus we would hold said tool to a higher standard than our own research which does not make sense.
When publishing a paper, do we estimate the carbon footprint or pollution ? And then compare it to the societal gains ? When we do we can then ask the same to other.
When publishing a paper, do we estimate the carbon footprint or pollution ? And then compare it to the societal gains ? When we do we can then ask the same to other.
while making the experiments behind the paper you don't have a carbon footprint ?
November 7, 2025 at 12:13 PM
while making the experiments behind the paper you don't have a carbon footprint ?
Do you provide the carbon footprint behind your paper ?
I am not a fan of qed but this is not a valid issue.
I am not a fan of qed but this is not a valid issue.
November 7, 2025 at 11:34 AM
Do you provide the carbon footprint behind your paper ?
I am not a fan of qed but this is not a valid issue.
I am not a fan of qed but this is not a valid issue.
maintenant c'est tout droit pour la 6ème étoile
October 31, 2025 at 11:57 AM
maintenant c'est tout droit pour la 6ème étoile
It would make our life a bit easier if it was the case.
But I think the data derives from the principles and not the other way around.
We have to have a hypothesis or a theory to analyze the data. Otherwise we do unsupervised DL and we don't learn much, from my pov at least.
But I think the data derives from the principles and not the other way around.
We have to have a hypothesis or a theory to analyze the data. Otherwise we do unsupervised DL and we don't learn much, from my pov at least.
October 16, 2025 at 10:04 AM
It would make our life a bit easier if it was the case.
But I think the data derives from the principles and not the other way around.
We have to have a hypothesis or a theory to analyze the data. Otherwise we do unsupervised DL and we don't learn much, from my pov at least.
But I think the data derives from the principles and not the other way around.
We have to have a hypothesis or a theory to analyze the data. Otherwise we do unsupervised DL and we don't learn much, from my pov at least.
Also the bases of the field are frail: what is a structure is unclear, what is function is unprecisely defined, a model can be 10 things. Which might make other conclusions more complicated.
October 15, 2025 at 2:43 PM
Also the bases of the field are frail: what is a structure is unclear, what is function is unprecisely defined, a model can be 10 things. Which might make other conclusions more complicated.
I would agree with most points you make. My doubts are whether we can really make biologically relevant conclusions from exploring big datasets. From most papers I have read that attempt to do that, they tend to find some correlations but not much more. (1/2)
October 15, 2025 at 2:43 PM
I would agree with most points you make. My doubts are whether we can really make biologically relevant conclusions from exploring big datasets. From most papers I have read that attempt to do that, they tend to find some correlations but not much more. (1/2)
Tu penses que ce serait mieux si c'est LR + RN qui vote ce budget avec les macronistes ?
A un moment il faut un budget sachant l'AN qu'on a.
A un moment il faut un budget sachant l'AN qu'on a.
October 15, 2025 at 11:58 AM
Tu penses que ce serait mieux si c'est LR + RN qui vote ce budget avec les macronistes ?
A un moment il faut un budget sachant l'AN qu'on a.
A un moment il faut un budget sachant l'AN qu'on a.
Pas du tout fan du PS, mais on a besoin d'un budget pour 2026 non ? Vu l'état du parlement il penchera à droite donc si on peut gratter des trucs je vais pas trop m'en plaindre.
Dans un autre univers c'est un budget voter avec le RN et LR et 15 mesure racistes dans le budget.
Dans un autre univers c'est un budget voter avec le RN et LR et 15 mesure racistes dans le budget.
October 15, 2025 at 8:18 AM
Pas du tout fan du PS, mais on a besoin d'un budget pour 2026 non ? Vu l'état du parlement il penchera à droite donc si on peut gratter des trucs je vais pas trop m'en plaindre.
Dans un autre univers c'est un budget voter avec le RN et LR et 15 mesure racistes dans le budget.
Dans un autre univers c'est un budget voter avec le RN et LR et 15 mesure racistes dans le budget.
Congratulation for the preprint, really enjoyed reading it !
In the paper you discuss that AF3 was fine-tuned on spaghetti like model from AF2. Do you then find that AF3 performs less well that AF3-like model ? What would be your recommended model to use for design ?
In the paper you discuss that AF3 was fine-tuned on spaghetti like model from AF2. Do you then find that AF3 performs less well that AF3-like model ? What would be your recommended model to use for design ?
October 13, 2025 at 4:10 PM
Congratulation for the preprint, really enjoyed reading it !
In the paper you discuss that AF3 was fine-tuned on spaghetti like model from AF2. Do you then find that AF3 performs less well that AF3-like model ? What would be your recommended model to use for design ?
In the paper you discuss that AF3 was fine-tuned on spaghetti like model from AF2. Do you then find that AF3 performs less well that AF3-like model ? What would be your recommended model to use for design ?
Makes sense, thanks !
October 13, 2025 at 8:42 AM
Makes sense, thanks !
The EMDB does not have quality standard to deposit maps ?
October 12, 2025 at 11:46 AM
The EMDB does not have quality standard to deposit maps ?
april's fool is really late this yearn
October 9, 2025 at 9:24 PM
april's fool is really late this yearn
He will likely dismiss the assembly and go for new election.
It seems very unlikely that he can find a coalition. He has stated that he will never resign. To me the second most likely is that he take exceptional power (article 16)
It seems very unlikely that he can find a coalition. He has stated that he will never resign. To me the second most likely is that he take exceptional power (article 16)
October 7, 2025 at 8:39 AM
He will likely dismiss the assembly and go for new election.
It seems very unlikely that he can find a coalition. He has stated that he will never resign. To me the second most likely is that he take exceptional power (article 16)
It seems very unlikely that he can find a coalition. He has stated that he will never resign. To me the second most likely is that he take exceptional power (article 16)
depuis quand ? Si Macron ne veut pas gouverner avec la gauche, ce qu'il montre depuis 3 ans, que peut y faire la gauche ?
Ils ne vont pas participer à un gvt avec un programme de droite soyons sérieux
Ils ne vont pas participer à un gvt avec un programme de droite soyons sérieux
October 6, 2025 at 8:21 AM
depuis quand ? Si Macron ne veut pas gouverner avec la gauche, ce qu'il montre depuis 3 ans, que peut y faire la gauche ?
Ils ne vont pas participer à un gvt avec un programme de droite soyons sérieux
Ils ne vont pas participer à un gvt avec un programme de droite soyons sérieux