Payea et al. find that ribosome depletion associated with senescence suppresses the integrated stress response (ISR) and leads to transcriptional remodeling of the senescence secretome. Stress-induced...

Parker et al. demonstrate that some proteins responsible for organizing ribonucleoprotein granules can chaperone intermolecular RNA-RNA interactions in addition to their role in scaffolding. These findings cement RNA-RNA interaction networks as a key component of granules, highlighting the need to further explore the regulation of RNA dynamics within granules.