This is so fun!

Thanks so much, Angel!!

Also if any of the above links do not work, you can always find free full-text versions of any papers we publish on our lab website! Reach out with any/all comments and questions! #toxicology #toxic #chemicals #health

www.kassotislab.org/publications...

Co-treatment with thyroid hormone did alleviate some of the metabolic health effects in cells, though we also found that these chemicals did not directly bind TR. They do interfere with co-regulatory protein recruitment, a likely mechanism mediating the thyroid receptor effects.
More to come!

Our newest paper, led by my postdoc, Dr. Roxanne Bérubé, dug into mechanism to try and find what pathways these chemicals disrupted, using both human and zebrafish cell assays. We honed in on thyroid receptor inhibition as a likely mechanism.
academic.oup.com/endo/article...

We followed that up by confirming this concept in zebrafish. Two publications demonstrated that both the "legacy" polyethoxylates as well as some of the newer "environmentally friendly" alternatives promoted adiposity.
Here: www.mdpi.com/2305-6304/10...
Also here: www.mdpi.com/2218-1989/13...

We've previously shown that they promoted fat cell development in cells - both promoting lipid accumulation and fat cell differentiation and also expanding the pool of fat cells by driving proliferation of pre-adipocytes. You can read some of that work here:

academic.oup.com/toxsci/artic...