Dr. Chris Kassotis
cdkassotis.bsky.social
Dr. Chris Kassotis
@cdkassotis.bsky.social
Assistant Professor at Wayne State University in Detroit. Endocrine Toxicologist studying endocrine disruptors, chemical mixtures, & metabolic health. Mediocre runner, amateur wine-maker and baker, and expert dog lover.
This is so fun!
February 13, 2025 at 5:54 PM
Thanks so much, Angel!!
December 9, 2024 at 10:11 PM
Also if any of the above links do not work, you can always find free full-text versions of any papers we publish on our lab website! Reach out with any/all comments and questions! #toxicology #toxic #chemicals #health

www.kassotislab.org/publications...
December 3, 2024 at 6:06 PM
Co-treatment with thyroid hormone did alleviate some of the metabolic health effects in cells, though we also found that these chemicals did not directly bind TR. They do interfere with co-regulatory protein recruitment, a likely mechanism mediating the thyroid receptor effects.
More to come!
December 3, 2024 at 6:06 PM
Our newest paper, led by my postdoc, Dr. Roxanne Bérubé, dug into mechanism to try and find what pathways these chemicals disrupted, using both human and zebrafish cell assays. We honed in on thyroid receptor inhibition as a likely mechanism.
academic.oup.com/endo/article...
academic.oup.com
December 3, 2024 at 6:06 PM
We followed that up by confirming this concept in zebrafish. Two publications demonstrated that both the "legacy" polyethoxylates as well as some of the newer "environmentally friendly" alternatives promoted adiposity.
Here: www.mdpi.com/2305-6304/10...
Also here: www.mdpi.com/2218-1989/13...
Nonylphenol Polyethoxylates Enhance Adipose Deposition in Developmentally Exposed Zebrafish
Alkylphenol polyethoxylates (APEOs), such as nonylphenol ethoxylates (NPEOs), are high-production-volume surfactants used in laundry detergents, hard-surface cleaners, pesticide formulations, textile ...
www.mdpi.com
December 3, 2024 at 6:06 PM
We've previously shown that they promoted fat cell development in cells - both promoting lipid accumulation and fat cell differentiation and also expanding the pool of fat cells by driving proliferation of pre-adipocytes. You can read some of that work here:

academic.oup.com/toxsci/artic...
December 3, 2024 at 6:06 PM