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Children with TSC not on meds (red solid line) looked shockingly similar to typically developing children (gray line). So I think the most interesting finding is that GABAergic medications were associated with a large change in beta power (lower peak freq, higher peak amp). 5/x

the finding of greater beta power in toddlers with TSC was driven by those children with high seizure severity (Fig B: red=high, yellow=low, gray=matched typical children) or those taking GABAergic antiepileptic medication (Fig D), or both. 4/x

Toddlers with TSC showed greater periodic beta power compared to age- and sex-matched typically developing children. That means more neural oscillations at frequencies between 12-30 Hz: compare the red and gray lines above the gray bar on the x-axis. But… 3/x

New paper alert! A story where secondary findings were perhaps more interesting than our original question. rdcu.be/d6LnQ Before I start, I extend deep thanks to the families in the study. 🧵 1/x