Castañeda Lab at SU
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castanedalab.bsky.social
Castañeda Lab at SU
@castanedalab.bsky.social
Using molecular biophysics, biochemistry, and cell biology to understand the intersection of protein quality control mechanisms and neurodegenerative disorders (ALS, FTD); IDPs, Ub biology, UBQLNs
The power of collaborations! With @shaharsu.bsky.social, his PD @jessniblo.bsky.social and CALVADOS3 (thanks to @lindorfflarsen.bsky.social ) we show how STI1 (red) may engage with sequences that match transient helices within IDRs of Ub-binding shuttle protein Dsk2 www.biorxiv.org/content/10.1...
May 23, 2025 at 1:18 PM
I think for NIGMS, MIRA applications are already reviewed at CSR if I understand correctly. www.nigms.nih.gov/Research/mec...
March 7, 2025 at 4:22 AM
For folks unable to download our recent review in @cp-trendsbiochem.bsky.social on protein quality control condensates, function, and potential therapeutic avenues - here's another link: authors.elsevier.com/a/1kNRo3S6Gf...

#Ub #PQC #condensates
January 11, 2025 at 3:02 PM
Am excited to run an interest group at #DiscoverBMB on the emerging role of condensates in regulating signal transduction! discoverbmb.asbmb.org/program/inte...
January 9, 2024 at 7:15 PM
Pls reskeet: We're accepting PhD apps to Syracuse University Biology! (Priority deadline of 1/4/24) Join a vibrant department: we are also recruiting three new faculty in epigenetics and neuroscience! Labs actively recruiting grad students are here: artsandsciences.syracuse.edu/biology/grad...
December 28, 2023 at 9:58 PM
We've learned that placing different N-terminal tags on UBQLN2 and UBQLN4 affect phase separation. The best tag we found thus far for UBQLNs is the recently engineered ALFA tag (www.nature.com/articles/s41...) The sequence grammar of the epitope matters. More:
www.sciencedirect.com/science/arti...
December 20, 2023 at 2:24 PM
If anyone is at ABRCMS this year - we are actively recruiting #PhD students to SU Biology (our lab is recruiting too!) Fee waivers available - come visit! (App deadline 1/4/24) (Please amplify) artsandsciences.syracuse.edu/biology/grad...
November 18, 2023 at 2:17 PM
Please repost - the Bio department at SU is hiring faculty - be my colleague in a growing and high-potential department! First post - we are hiring in epigenetics, broadly defined. Excellent resources and collaborations! Priority deadline of November 1: www.sujobopps.com/postings/100...
October 21, 2023 at 5:21 PM