Dr Cassandra Kennedy
@cassandrakennedy.bsky.social
Chemical biologist at The Francis Crick Institute, previously Tate group PhD at Imperial
This was such a great project to work on - thanks @katrinrittinger.bsky.social and the GSK ChemBio team for letting me have so much fun! Shout out to my co-authors on bsky: @diegoesposito.bsky.social @janedudley.bsky.social @katmcphie.bsky.social @jtbush.bsky.social @crick.ac.uk (4/4)
May 21, 2025 at 2:26 PM
This was such a great project to work on - thanks @katrinrittinger.bsky.social and the GSK ChemBio team for letting me have so much fun! Shout out to my co-authors on bsky: @diegoesposito.bsky.social @janedudley.bsky.social @katmcphie.bsky.social @jtbush.bsky.social @crick.ac.uk (4/4)
And second: using covalent fragment screening and HTC-D2B to develop inhibitors of SspH1/2, representing the first time the NEL family has been liganded chemrxiv.org/engage/chemr... (3/4)
Covalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2
As the global fight against antimicrobial resistance in bacteria becomes increasingly pressing, new tool compounds are needed to study and evaluate novel therapeutic targets. Here, cysteine-directed f...
chemrxiv.org
May 21, 2025 at 2:26 PM
And second: using covalent fragment screening and HTC-D2B to develop inhibitors of SspH1/2, representing the first time the NEL family has been liganded chemrxiv.org/engage/chemr... (3/4)
First: our structure of SspH1, together with NMR and SAXS to understand the conformational dynamics of the protein in complex with ubiquitin and PKN1. Was great fun working with and learning from @diegoesposito.bsky.social www.biorxiv.org/content/10.1... (2/4)
Conformational dynamics of the bacterial E3 ligase SspH1
The SspH/IpaH family of novel E3 ligases (NELs) are found in a number of Gram-negative bacteria and are used to target host enzymes for degradation to support pathogenesis. These E3 enzymes are autoin...
www.biorxiv.org
May 21, 2025 at 2:26 PM
First: our structure of SspH1, together with NMR and SAXS to understand the conformational dynamics of the protein in complex with ubiquitin and PKN1. Was great fun working with and learning from @diegoesposito.bsky.social www.biorxiv.org/content/10.1... (2/4)